Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf

... 4671 Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 Huma ... of histidine residues in PETN reductase inferred to be involved in ligand binding and counterpart residues in related enz...

Ngày tải lên: 20/02/2014, 02:21

... showed the pre- steady-state two-electron reduction of flavin, followed by interdomain one-electron transfer from flavin to heme, resulting in the formation of the flavin semi- quinone radical and reduced ... isosbestic point of heme (449.0 nm) decreased similarly in both Fig. 1. Stereo representation of the heme in CDH and the amino acids within 4 A ˚ of the...

Ngày tải lên: 19/02/2014, 18:20

... observing the environment including the context, world knowledge, and target words in the neighborhood. The most influential elements in the environment are of course the other words in the ... representations. II) The weight of each element for constraining the ambiguity of target words is determined automatically by following the term frequency and...

Ngày tải lên: 20/02/2014, 18:20

... and of the kanamycin insertion mutant nirF strain (SBN03) in the upper right panel. Growth of SBN11 (DnirF) is shown in the bottom left panel and of SBN13 (DnirF) containing pEG276-nirF in the ... activity of NirF Interestingly, like NirN, NirF shares sequence similar- ity with the C-terminal d 1 heme-containing domain of cytochrome cd 1 . Strikingly, the axial...

Ngày tải lên: 15/02/2014, 01:20

... com- posed of an extracellular ligand-binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. The binding of a ligand to the extracel- lular domain of the EGFR induces ... dimeriza- tion, activation of the intracellular kinase domain and autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptor. The tyros...

Ngày tải lên: 16/02/2014, 09:20

... (2010) Solution structure of the C-terminal X domain of the measles virus phosphoprotein and interaction with the intrinsically disordered C-terminal domain of the nucleoprotein. J Mol Recognit ... disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinct sites and remains predomina...

Ngày tải lên: 18/02/2014, 04:20

... decrease in PMP-BSA binding. It thus appears that tethering of the C-terminal end of the ectodomain is important for both IGF-II and PMP- BSA binding. In summary, the major findings obtained in the present ... binding must only be a local effect because binding of PMP-BSA, which binds to other sites in the ectodomain of these heterodimers, resulted in the predic...

Ngày tải lên: 18/02/2014, 08:20

... overexpression of SSeCKS reduced VEGF expression and induced angiopoietin-1 (Ang-1), thereby promoting the expression of tight junction proteins and strengthening the bonds between brain endothelial cells [19]. ... and differences in the luminal–abluminal polarity of the endothelium. To bridge the gap between in vitro condi- tions and the actual environment, ex...

Ngày tải lên: 18/02/2014, 11:20

... organs, including the brain, is regulated by the VEGF system in combination with other signaling systems such as the angiopoietin–Tie, ephrin–Eph, Delta–Notch sys- tems, and the Wnt pathway. Furthermore, ... astrocytes, and the tight junctions of vascular endothelial cells (ECs) in the BBB are well organized with claudins and ZO- proteins through a decrease in angiog...

Ngày tải lên: 18/02/2014, 11:20

... out- come and the number of circulating EPCs. In rodent models of focal cerebral ischemia, there was a strong correlation between the volume and severity of infarcts and the absolute number of circulating ... attractiveness of this approach lies in the fact that minocycline can be easily used in humans. Taken together, the accumulating experimental and clinic...

Ngày tải lên: 18/02/2014, 11:20