Tài liệu Báo cáo khoa học: Small molecule regulation of Sir2 protein deacetylases ppt

... Therefore, Fig. 3. (A) Known inhibitors of Sir2 deacetylases. (B) Examples of known activators of Sir2 deacetylases. O. Grubisha et al. Small molecule regulation of Sir2 protein deacetylases FEBS Journal 272 ... protein Small molecule regulation of Sir2 protein deacetylases O. Grubisha et al. 4614 FEBS Journal 272 (2005) 4607–4616 ª 2005 FEBS MINIREV...

Ngày tải lên: 20/02/2014, 01:20

... of their target genes. Indeed, several examples of feedback regulation that involve miRNAs have been reported. Below, we attempt to summarize our recent understanding of feedback regulation of ... expression of estrogen receptor-a (ERa) is autoregulated by miR-18a, -19b and -20b, which in turn are upregulated by the activation of ERa. This mechanism of regulation provides...

Ngày tải lên: 14/02/2014, 19:20

... the internal Fig. 1. Plant aspartic proteinase precursors. Comparison of the amino acid sequences of representative members of the A1 family of plant aspartic proteinases. The regions corresponding ... form of cyprosin was processed in different isoforms by the excision of the prosegment and of most of the PSI [21]. Conversely to what has been found in vivo [31], heavy and lig...

Ngày tải lên: 19/02/2014, 12:20

... extension of our joint inference approach we may soon be able to exceed the performance of a single manual annotator. Our analysis of the types of errors, and the per- formance of our knowledge ... errors of each type. Errors of identifica- tion will be further subdivided by type (missing names, spurious names, and boundary errors). We believe such detailed understanding...

Ngày tải lên: 20/02/2014, 12:20

... of the same derived tree. This can be easily seen in that any adjunetion of/ 32 at a node at which an adjunction of/ 31 occurs could instead be replaced by an adjunction of/ 32 at the root of/ 31. ... root of adjunction rule: Allow moving from the bottom (rather than the top) of a node to the top of the root of a modifier auxiliary tree (Figure 6c). As can be seen from t...

Ngày tải lên: 20/02/2014, 21:20

... mechanism of regulation of both domains involves a common iron dependent process [74,75,79]. Regulation of HIFa subunits by oxygen-dependent prolyl and asparaginyl hydroxylation A variety of oxygen ... recruitment of other factors such as histone deacetylases or VHL [98], or may well be an artefact of overexpression. Structural implications Synthetic peptides composed of t...

Ngày tải lên: 20/02/2014, 23:20

... the three previously reported isoforms [9], one of which is LF RNase, further isoforms of this protein exist that possess other enzyme activities. The nature of the structural variations that ... [28]. Specificity of the hydrolysis of malto-oligosaccharides was determined after separation of products by TLC and HPLC on a Lichrosorb-NH 2 column [28]. One unit of activity was defi...

Ngày tải lên: 21/02/2014, 00:20

... the processing of apicoplast protein leader sequence. Inhibition of any of these activities could contribute to MA interference in the maturation of the parasite. Polypharmacology of MA The observed ... mixing 100 l L of 100 l m ZnSO 4 .H 2 O, 200 lL of 0.3 m Na 2 CO 3 pH 10, 10 lL of com- pound (MA or EDTA as control) and 6 lL of Eriochrome Black T (5 mgÆmL )1 in ethanol,...

Ngày tải lên: 14/02/2014, 14:20

... Leu23 of the CT-extension of the rmErv-C +CT molecule with a minimum distance of 1.9 A ˚ between two atoms of the two leucines (Fig. 8A). Because the Leu23 residue of the CT-extension of the ... (2003) Functions of propeptide parts in cysteine proteases. Curr Protein Pept Sci 4, 309–326. 3 Cygler M & Mort JS (1997) Proregion structure of members of the papain superfa...

Ngày tải lên: 14/02/2014, 14:20

... recruitment of MOF to recently transcribed regions, especially at the 3¢ ends of genes where H3-K36me3 is enriched [128]. In mammalian cells MOF also exists as part of a sepa- rate MOF–MSLv1 complex ... free of DNA methylation because they also recruit factors that lead to elimination of DNA meth- ylation. Foremost among these is the CXXC domain protein Tet1 that belongs to a fami...

Ngày tải lên: 14/02/2014, 18:20