Tài liệu Báo cáo khoa học: Template requirements and binding of hepatitis C virus NS5B polymerase during in vitro RNA synthesis from the 3¢-end of virus minus-strand RNA docx
... [
125
I]TC-PCSK9 binding increased as cell surface LDLR density
increased. Unlabeled wild-type and two gain -of- function mutants of
PCSK9 reduced binding of [
125
I]TC-PCSK9. The Scatchard plot of the
binding- inhibition ... HepG2
cells increased following growth in the absence of lipo-
proteins, and there was a corresponding increase in the
binding of [
125...
... other bacteria. Its
interaction with macrophages induces a decrease in the
production of the pro -in ammatory cytokines tumour
necrosis factor-a and interferon (IFN) -c and an over-
production of ... to
be the only one that is common to all bacteria. In Yer-
sinia, the increased synthesis of LcrV triggered by the
activation of the system leads to the titration...
... (Roche Diagnostics) and the
following PCR primer sets: 5¢-GGAGATCTCCAGTGA
TATCGACCA-3¢ and 5¢-ACGGCTTCTACGGATCGAA
ACT-3¢ for PPARc ,5¢-AAGACAGCTCCTCCTCGAAGG
TT-3¢ and 5¢-TGACCAAATCCCCATTTACGC-3¢ ... aP2,
5¢-ATCCATGGATGGACGGTAACG-3¢ and 5¢-CTGGA
TCCCAATACTTCGACCA-3¢ for LPL, 5¢-TGGGTTGG
CTGCTTGTG-3¢ and 5¢-GCGTGGGCAGGATGAAG-3¢
for SCD, 5¢-GATGTGGAACCCATAACTGGATTCAC-3¢
and 5¢-GGTC...
... most convincing
evidence supporting this hypothesis was the rescue
of the bone mass phenotype of the ob ⁄ ob mice by
intracerebroventricular (ICV) infusion of leptin in the
hypothalamic region, clearly ... demonstrating that the
inhibitory action of leptin on bone formation is medi-
ated by a central circuit [25]. Further supporting the
importance of leptin in the...
... cob(II)alamin. Reduction of the Co centre
promotes the dissociation of the lower dimethylbenz-
imidazole base of the cofactor. Consistent with this,
the crystal structure of the cobalamin -binding domain
Homocysteine
Methionine
Co
Methylcob(III)alamin
Cob(I)alamin
Primary
turnover
cycle
H
CH
3
H
4
folate
AdoHyc
Cob(I)alamin
Cob(II)alamin
H
4
folate
Co
NADPH
A
doMet
e
–
FA...
... levels of both b-conglycinin and glycinin,
as pro-b-conglycinin and proglycinin are transient pro-
tein forms that are present in the ER prior to process-
ing in the protein storage vacuoles. The synthesis ... third amino acids in classic redox-
active CGHC motifs with methionine or isoleucine
and asparagine in GmPDIL-3a and GmPDIL-3b may
be the cause of the la...
... by
SREBP- 1c in the liver inhibits processes regulating
insulin signaling, such as glycogen synthesis, and con-
tributes to the physiological switching from glycogen
synthesis to fatty acid synthesis during ... hepatosteatosis
and pancreatic b-cell dysfunction [25,26].
Insulin resistance in liver and impaired
insulin secretion in b-cells
Molecular dissection of th...
... employed these toxins
(mainly OA) to examine cell–matrix interactions and
cell–cell contacts, either directly by controlling struc-
tural adhesion proteins, or indirectly by affecting pro-
teins involved ... activity. Among the structures implicated in
cell–cell interactions, tight junctions are specialized
contact sites between the cell membranes of adjacent
cells in which the...