Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx

... gliosis and expression of the small heat Y. Sun and T. H. MacRae Small heat shock proteins and disease FEBS Journal 272 (2005) 2613–2627 ª 2005 FEBS 2625 shock proteins Hsp27 and [alpha]B-crystallin ... (2004) Testis-specific human small heat shock protein HSPB9 is a cancer ⁄ testis antigen, and potentially interacts with the dynein subunit TCTEL1. Eur J...

Ngày tải lên: 19/02/2014, 18:20

... jecorina genome. Then, all putative hydrophobins, inclu- ding the newly identified hydrophobin from H. jecorina, were used to identify further proteins with similar domains, and finally all hypothetical ... Centre of Finland, Espoo, Finland Hydrophobins are small proteins thought to be ubi- quitous in filamentous fungi. They are usually present on the outer surfaces of cell walls o...

Ngày tải lên: 19/02/2014, 02:20

... of the second guanine in the GAGA motif. Olson and Cuff [28] also proposed that this residue was involved in substrate binding, interacting with the loop-closing guanine base (the first G after the ... 234 and 235 [9]. Of theses residues, only Arg213 is in the vicinity of the active site of RTA. In order to establish the role of arginyl residues around the active...

Ngày tải lên: 19/02/2014, 12:20

... viral infections or heavy alcohol consumption and to examine the possible role played by cells and mole- cules of the immunological system in hepatic injury and repair. Understanding the interdependence ... coordinated changes in the expression of the transferrin receptor and ferritin; (b) developed iron accumulation and (c) increased the prooxidant state and th...

Ngày tải lên: 19/02/2014, 16:20

... Charniak and Johnson (2001) and split the corpus into main training data, held-out train- ing data and test data as follows: main training con- sisted of all sw[23]∗.dps files, held-out training con- sisted ... model training data. We solve this by dividing the Switch- board training data into 20 folds. For each fold we use the 19 other folds to construct a language model and the...

Ngày tải lên: 20/02/2014, 04:20

... section and scheme of the coronal section at E14.5 in (F). (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline. Surprisingly, the HSF2 ... FEBS 113 Trinklein ND, Chen WC, Kingston RE & Myers RM (2004) Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human...

Ngày tải lên: 18/02/2014, 04:20

... observed, includ- ing that Mxi1-SRa appears to be the predominant transcript in the adult intestine and in the developing embryo, whereas Mxi1-SRb transcripts predominate in the adult liver and kidney ... that in (B) and (C), although 4¢,6-diamidino- 2-phenylindole labels all of the cell nuclei (see also phase images), only some of the cells express the introduced...

Ngày tải lên: 18/02/2014, 16:20

... pathology of the disease. To reach in amed sites, neutrophils traverse various barriers, including the endothelium, basement mem- brane (intestine) ⁄ interstitium (lung) and epithelium, in response ... model with the ability to induce human IL-8 expression restricted to the intestinal epithelium [5]. The results from this transgenic model showed that although acute inductio...

Ngày tải lên: 19/02/2014, 02:20

... nm, comparable to the inhibition of the aminopeptidase cathepsin H (K i ¼ 30 nm ). In comparison with other cystatins, cystatin F is a rather slow binding inhibitor of the cathepsins, characterized ... Cystatins are generally rather non- selective inhibitors. An interesting feature of cystatin F is the 100-fold stronger inhibition of cathepsins F, L, and V than of cathepsin S. Cat...

Ngày tải lên: 19/02/2014, 17:20

... crystals containing a tubulin dimer in complex with small ligands and ⁄ or other proteins, and some by modeling. No structure determination is available for the human proteins and therefore we ... notwith- standing the shift in the ligand position with respect to the E1 complex. Due to the described differences between the two binding modes, the interactions inv...

Ngày tải lên: 16/03/2014, 13:20