... restored the bacterial protein [21,33].Interestingly, the same difficulty in stripping off the metallocofactor from the protein has been describedfor murine adenosine deaminase, a member of the amidohydrolase ... structures of human and bacterialACMSD, demonstrating that the region surroundingresidues involved in catalysis is more hydrophobic in the human, rather than in the bacterial protein. Finally, ... cerebral malaria and in the brain of a murine model of the syndrome[18,19]. Interestingly, picolinate is reportedly able toprevent the neurotoxic effects of quinolinate in the ratcentral nervous...