Tài liệu Báo cáo khoa học: The social life of ribosomal proteins doc

... which in the minds of many in the field has left ribosomal proteins in the dark as ‘merely glue’. In this review we highlight some of the many import- ant biological roles of ribosomal proteins, ... 2005) doi:10.1111/j.1742-4658.2005.04651.x Ribosomal proteins hold a unique position in biology because their func- tion is so closely tied to the large rRNAs of the...

Ngày tải lên: 19/02/2014, 17:20

... footprinting. Loss of the two pocket proteins leads to deregulation of the B-Myb promoter during the cell cycle. Re-intro- duction of p107, and to some extent also p130, causes repression of the B-Myb ... located upstream of the CDE-like site [46]. These observations and the fact that activation does not rely on CCAAT-boxes, NF-Y or Sp1 proteins, leave open the que...

Ngày tải lên: 16/02/2014, 09:20

... helix 4 of the NTD of a neighboring subunit in the hexamer. Additional contacts involve helix 11 of the CTD and the C-terminal end of helix 7 of the NTD of the neigh- boring subunit. The NTD–CTD ... model of the NTD hexamer from MLV, the superimposed model of the NTD hexamer from HIV-1, the high-resolution X-ray model of the modified CA hexamer from HI...

Ngày tải lên: 18/02/2014, 06:20

... which corresponds to the a-helix 7 of NTD. This region is important for the formation of CA hexamers [6]; there- fore, this peptide could inhibit the formation of the hexamers, and assembly of the HIV-1 ... the X-ray structure of the nonmu- tated-CTD–CAI complex [28] (Fig. 2A, main panel). The aromatic moiety of Phe3, together with Leu6 and Ile1, are the residues...

Ngày tải lên: 18/02/2014, 06:20

... Furthermore, the pro-peptide of GDF-8 impairs interaction of the mature part with its receptors [16]. In the case of BMP-9, the pro-pep- tide appears not to alter significantly the activity of the mature ... biological function of the pro-form of bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factor b (TGFb) ⁄ BLP superfamily. The role...

Ngày tải lên: 18/02/2014, 06:20

... present for the last four residues at the C-terminus. The stereochemistry of the model has been assessed using the program procheck [23]. Ninety per cent of the residues fall in the most favoured regions ... understanding of the ACMSD catalytic mechanism is still incomplete. In light of the reported ACMSD upregulation in the liver of streptozotocin-induced diabet...

Ngày tải lên: 18/02/2014, 06:20

... [10]. Although the occurrence of family 33 CBPs has been known for some time [23], the present results provide only the third demonstration of the accessory function of these proteins. The effect of LlCBP33A ... into the chitinolytic poten- tial of L. lactis, the present results provide only the third example of the role of family 33 CBPs in the deg- radatio...

Ngày tải lên: 18/02/2014, 08:20

... that most of the RIP substrates, including Jagged-1, actu- ally fall in the left-hand side of the plot (natively unfolded proteins) . All the proteins that clearly fall in the right-hand side of the ... typical of disor- dered proteins. The content of secondary structure was estimated through deconvolution of the CD spectrum in the range 190–240 nm using seve...

Ngày tải lên: 18/02/2014, 16:20

... (enzyme I of the PTS), the first protein in the cascade of proteins forming the PTS, to HPr, the histidine-phosphocarrier protein. HPr is the smallest protein in the protein cascade of the PTS and ... 271) 2177 Validation of the LEM in analysis of scHPr data The use of LEM in several proteins has resulted in the complete determination of the thermodyna...

Ngày tải lên: 19/02/2014, 12:20

... recognition of p NPP by the pNPP site at t he rear su rface of the N -domain is due the formation of an hydrogen bond of the NO 2 -group of pNPP with the amino group of N398. The hydrophobicity of the ... 6B). Docking of the substrate to the latter model [20] revealed that pNPP binds Table 3. Comparison of the primary structures of isoforms of Na + /K...

Ngày tải lên: 19/02/2014, 16:20