... a protein implicated in the control of malignancy in melanoma in man [8,9]. In the verteb-rate lens, the b and c crystallins together account for the majority of the soluble proteins (the other ... encodes the first two structural motifs, and hence the N-ter-minal domain of the protein, just as in the genes forcS and cA–F. However, the second half of the genehas the structure of a b-crystallin ... exonsencoding the two motifs of the C-terminal domain. The crygn gene is thus a hybrid of b and c crystallingene structures, apparently an intermediate in the evo-lution of the c-crystallins from the...