Tài liệu Báo cáo khoa học: Identification of GAS-dependent interferon-sensitive target genes whose transcription is STAT2-dependent but ISGF3-independent doc

... rate of colonization was associated with an increased risk of the development of M. catarrhalis-mediated diseases [3]. Currently, the molecular pathogenesis of M. catarrhalis infection is not ... catarrhalis is responsible for 15–25% of all of these cases [4,5]. In adults with chronic obstruc- tive pulmonary disease, which is the fourth leading cause of death in the USA, t...

Ngày tải lên: 18/02/2014, 14:20

... knowledge of Ewing’s sarcoma (EWS) derives primarily from studies of a group of dominant oncogenes that arise due to chromosomal transloca- tions in which EWS is fused to a variety of cellular transcription ... Oyoshi 1 1 Department of Chemistry, Faculty of Science, Shizuoka University, Japan 2 Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Kagawa, Jap...

Ngày tải lên: 15/02/2014, 01:20

... consisting of a strong short- and a moderate long-term response. Moreover, after 7–10 days of exposure, we detected differential expression of a number of genes that encode elements of the transcription ... ribo- somal protein L10, is a transcription cofactor that inhibits activation of AP-1 transcription factors. QM protein is implicated in the conversion of a broad...

Ngày tải lên: 18/02/2014, 16:20

... analysis of a cDNA library constructed by suppressive subtraction of whole-embryo mRNA at late neurogenesis stages (hindbrain swelling + heart tube with peristalsis) from that at early neurogenesis ... Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan 2 Division of Marine Biosciences, Graduate School of Fisheries Science, Hokkaido University,...

Ngày tải lên: 18/02/2014, 17:20

... Co-expression of CYP93E1 and b-amyrin synthase in S. cerevisiae yielded olean-12-ene-3b,24-diol. This is the first identification of triterpene hydroxylase cDNA from any plant species. Successful identification ... understanding of the biosynthesis of triterpene saponins is required, including the enzymes catalyzing the sequence of reactions and the genes encoding these enzym...

Ngày tải lên: 19/02/2014, 07:20

... 1581 Identification of GAS-dependent interferon-sensitive target genes whose transcription is STAT2-dependent but ISGF3-independent Melissa M. Brierley 1 , Katie L. Marchington 1 , Igor Jurisica 2 and ... genes whose expression is IFN-inducible and independent of ISGF3 but highly dependent on the STAT2 DNA binding domain. This report is the first analysis of...

Ngày tải lên: 19/02/2014, 07:20

... the presence of 10 mm CaCl 2 , as described in Experimental procedures. Of the nine cell lines tested, OVISE, Fig. 1. Analysis of noncleaved and cleaved forms of IGFBP-rP1 in conditioned media of eight ... processing in culture of OVISE cells. OVISE cells at 50–60% confluence in 60 mm culture dishes were transfected with 200 pmol of each of three siRNAs (si973, si1513 and si257...

Ngày tải lên: 19/02/2014, 07:20

... ura3D0 his3D1 utr1::kanMX4 yef1::HIS3 This study MK803 MATa leu2D0 lys2D0 ura3D0 his3D1 utr1::kanMX4 pos5::HIS3 This study MK804 MATa leu2D0 lys2D0 ura3D0 his3D1 yef1::kanMX4 pos5::HIS3 This study MK933 ... and Pos5p can contribute significantly to this kind of growth only in the absence of the critical contributor (Utr1p). Discussion The genomic sequence of the yeast S. cerevisiae con-...

Ngày tải lên: 20/02/2014, 01:20

... zinc-binding motif) of His505 in the ACE2 sequence is very similar to the location of the catalytic histidines in both ACE and thermolysin, sug- gesting that His505 is the catalytic histidine of ACE2. On ... effect of chloride ions on enzyme activity was investigated (Fig. 4). The hydrolysis of Mca- Fig. 3. Role of His505 and His345 in catalysis. Schematic of the proposed re...

Ngày tải lên: 20/02/2014, 01:20

... Abbott, C.M. (1998) The lethal mutation of the mouse wasted [wst] is a deletion that abolishes expression of a tissue-specific isoform of translation elongation factor 1alpha, encoded by the Eef1a2 ... highlight the mechanism of action of our cytotoxic GT oligonucleotides. In this article, we report the identification of eukaryotic elongation factor 1 alpha (eEF1A) as a nuclear...

Ngày tải lên: 21/02/2014, 00:20