Tài liệu Báo cáo khoa học: Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae docx

Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc

... containing atRE in the presence of 1mM bipyridine (B) and liposomes containing atRE, in the presence of 1 mM bipyridine and 6 mM FeSO4(C). The generated retinoidswere analyzed by HPLC. The ... contribute toproviding chromophore to melanopsin to maintaintheir light sensitivities. The expression and function of RPE65c in other cell types in the retina remains to beinvestigated.Earlier ... two retinoid-binding proteins in vertebrate retina. J Cell Biol 97, 703–712.32 Bok D, Ong DE & Chytil F (1984) Immunocytochemi-cal localization of cellular retinol binding protein in the rat...

Tài liệu Báo cáo khoa học: Bone morphogenetic proteins in the early development of zebraﬁsh pptx

... Follistatin, Chordin and Noggin[12]. These proteins are antagonists of BMP and othermembers of the TGF-b family, binding to and inhibit-ing these signaling molecules from binding to theirreceptors ... theirreceptors in the extracellular space, thus inhibiting ven-tralizing activities. Of these proteins, Chordin has along-range effect. In Xenopus, expression of the chordingene is localized to the dorsal ... protein 2 in the early devel-opment of Xenopus laevis. Mech Dev 52, 357–370.7 Fainsod A, Steinbeisser H & De Robertis EM (1994)On the function of BMP-4 in patterning the marginalzone of the...

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... residues directly involved in ligandbinding, presumably abolishing the interaction withsignaling partners. The remaining mutations alteramino acids located outside the ligand-binding pocketand ... pro-tein kinase B (PKB)]. In AKT, a cysteine substitution of the corresponding R25 in the pleckstrin homology(PH) domain also results in loss of function [16,17],thereby demonstrating related ... locations of the missense mutation in the BTK PH domain; arginine 28 is in dark blue, encircled in red. Bottom left: SH2 domain. Right: kinasedomain. The mutated residues are indicated in yellow,...

Tài liệu Báo cáo khoa học: Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress pdf

... reaction of the luciferin ⁄ luciferase mixture, energydonor (ATP) and oxygen results in the emission of light. The intensity of the bioluminescence was detected using aluminometer, and the mitochondrial ... in fatty acid utilization,increase in glucose utilization) in the murine femaleheart. Moreover, our data suggest that these changesoccur in an Akt-independent manner. Further studiesare therefore ... 2007)doi:10.1111/j.1742-4658.2007.06051.x The mechanisms underlying increased cardioprotection in younger femalemice are unclear. We hypothesized that serine-threonine protein kinase(protein kinase B; Akt) triggers...

Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx

... integrin-dependentcell volume sensing and signaling integrates into the overall context of insulin signaling. Similarly, sensing of glutamine-induced hepatocyte swelling by integrinsfeeds into ... hepatocyte swelling [12,13], insu-lin-induced hepatocyte swelling is registrated by the integrin system, leading to a Src-dependent activation of the p38-type MAPK and thereby inhibition of autophagic ... outcome.This minireview summarizes recent progress in the understanding of howosmosensing and osmosignaling integrate into the overall context of growthfactor signaling and the execution of apoptotic...

Tài liệu Báo cáo khoa học: An intermediate step in the evolution of ATPases – a hybrid F0–V0 rotor in a bacterial Na+ F1F0 ATP synthase pdf

... covalently linked hairpins in the membrane [10]. Importantly, the ion-binding site is not conserved in hairpin one. If one assumes the same number of transmembrane helices in V0and F0, the rotor of eukaryal ... the densities correspond to the N- andC-terminal helices of the c ring, respectively. The C-terminal helices show a clear handedness, and two of the rings face in the opposite direction in the membrane ... represent the view from the cytoplasm (open rings in AFM) and the red ones the view from the extracellular side (smaller, closedrings in Fig. 3). The inner and outer diameters of the rings, measured...

Tài liệu Báo cáo khoa học: Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR) doc

... predicted to originate from an N-glycosyllinkage between the anomeric carbon of the ribose,which in the precursor NAD is linked to nicotinamide,and the amino ⁄ imino group at C6 of the adeninemoiety ... between the anomericC1 of this ribose moiety (commonly termed ‘northernribose’ while the ribose linked to N9 of adenine iscalled the ‘southern’ ribose; Fig. 1) and the N1 of the adenine ring [4].Besides ... Possibilities are the direct binding of cADPR to the ryanodine receptoror binding via a separate cADPR binding protein. In addition to Ca2+release, cADPR also evokes Ca2+entry. The underlying mechanism(s)...

Tài liệu Báo cáo khoa học: Kinetic basis for linking the ﬁrst two enzymes of chlorophyll biosynthesis doc

... reaction intermediate, resulting in a reduction in the lag phase of product accumulation, and an increase in initial rate of product evolution. Furthermore, the presence of ChlH increases the magnitude ... [14]. The current value is a better estimate of intermediateaccumulation, as the ﬁt in Fig. 3B considers only the evolution of intermediate. The rate constant for the decay of intermediate in the ... here extend the in uence of ChlH and show for the ﬁrst time the way in which this protein exerts a strong effect on the next enzyme in the pathway, ChlM. Inspection of the ChlH titration in Fig....

Tài liệu Báo cáo khoa học: "Liars and Saviors in a Sentiment Annotated Corpus of Comments to Political debates" pdf

... definite descrip-tions and nicknames. 1 Introduction Most of the existing approaches to opinion mining propose algorithms that are independent of the text genre, the topic and the target involved. ... reinforces the idea that the real challenge in performing opi-nion mining in certain realistic scenarios, such as in user comments, is correctly identifying the least frequent, yet more informative, ... Also interesting is the information contained in the distributions of positive opinions. that there is a large correlation ( The Pearson corrlation coefficient is r = 0.917) between the of...

Tài liệu Báo cáo khoa học: "Automatic error detection in the Japanese learners’ English spoken data" pdf

... categories.Method C * there is telephone and the books on the desk. Eb: The word in the beginning of the part which should be replaced. Ee: The word in the middle or the end of the part which ... word and the one preceding/ the targeted word and the one following/ the targeted word and the two preceding/ the targeted word and the two fol-lowing), and the first and last letters of the word. ... i.e., the targeted word and the two preceding and follow-ing words, their word classes, their root forms, five combinations of these (the targeted word, the one preceding and one following/ the...

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