Tài liệu Báo cáo khoa học: FOXM1c transactivates the human c-mycpromoter directly via the two TATA boxes P1 and P2 docx

... pTATA-WAF-luc, pP1-jun-luc, pP2-jun-luc, pjun -P1- luc, pjun -P2- luc,pP1(junTATA)luc, pP2(junTATA)luc, pP1(WAFTATA)luc, pP2(WAFTATA)luc, pjun(P 1TATA) luc, pjun(P2TA-TA)luc, pWAF(P 1TATA) luc and pWAF(P 2TATA) lucwere ... Consequently, these interactionsshould be important for the new mechanism by which FOXM1c transactivates via the c-myc P1 and P2 TATA boxes. Binding of TBP and FOXM1c to the P1 and P2 TATA boxes Because ... Hybrids exchanging only the TATA boxes between P1 or P2 and the c-jun or waf1 ⁄ (p21 ) promot-ers, and vice versa, showed that the c-myc P1 and P2 TATA boxes are themselves the FOXM1c- responsiveelements...

Tài liệu Báo cáo khoa học: A DExD⁄ H box RNA helicase is important for K+ deprivation responses and tolerance in Arabidopsis thaliana docx

... acid position of the ﬁrst residue in each motif.(B) Scheme of the AtHELPS gene. Black boxes represent exons and blank boxes represent introns. The position and orientation of the T-DNA insertion ... Characterization and expression analysis of the T-DNA insertion for the helps mutant and OE lines of AtHELPS. (A) The conservedmotifs of DExD ⁄ H-box RNA helicases in AtHELPS. Numbers represent the amino ... of the AtHELPS protein sequence. Black boxes represent I, Ia, Ib, II, III, IV, V, and VI. The arrow marks the highly conserved residues Asp-Glu-Val-His in motif II. The detailed schemeof the...

Tài liệu Báo cáo khoa học: Identiﬁcation of Ewing’s sarcoma protein as a G-quadruplex DNA- and RNA-binding protein ppt

... poly G and poly U RNA in vitro [8]. On the other hand, Hume et al. [15] suggested that EWSbinds to the proximal-element DNA of the macro-phage-speciﬁc promoter of the CSF-1 receptor gene. The ... (lanes 2 and 4) and 32P-labeled ETS-1(lanes 3 and 4) or ssDNA L (lanes 1 and 2). (B) EMSA was per-formed with EWS (lanes 2, 4 and 6) and 32P-labeled Htelo (lanes 3 and 4), dsHtelo (lanes 5 and ... (lanes 2 and 4) and 32P-labeled Htelo (lanes 1 and 2) orrHtelo (lanes 3 and 4). (B) EMSA was performed with RGG3 (lanes2 and 4) and 32P-labeled rHtelo (lanes 1 and 2) or mut rHtelo (lanes3 and...

Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc

... (tfap2a) and also AP-2b(tfap2b) in the development of the facial ectoderm, and for signals from this epithelium that induce skeletogen-esis in NCCs. Zebraﬁsh embryos lacking both tfap2a and ... expres-sion in the face and limbs. In a follow-up study, theyfound that this conserved cis-acting sequence serves tomaintain a level of AP-2a expression that limits the size of the hand plate and the ... AP-2d, and AP-2e. The proline-rich and glutamine-rich N-terminus, which is important fortransactivation, is shown in yellow, and contains the PY-motif (green). The helix–span–helix domain at the...

Tài liệu Báo cáo khoa học: Erythrochelin – a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea docx

... a hOrn and a haOrn moiety.Furthermore, a long-range1H–13C correlation wasdetected between the carbonyl carbon of the serine and the d-CH2of the hOrn, which constitutes the DKP.Therefore, ... S3–7. The observed NOE contacts and the long-range1H-13C correlations veriﬁed the structure and are listed in listed in Tables S5 and S6. On the basis of the results obtained by NMR, the determinedsequence ... connection between the terminal ac-haOrn1 and the Ser2, whereas the other two were for a sequentialconnection between a d-N-hydroxyornithine and ad-N-acetyl-d-N-hydroxyornithine and its reverse,...

Tài liệu Báo cáo khoa học: Exposure of IgG to an acidic environment results in molecular modiﬁcations and in enhanced protective activity in sepsis doc

... (Fig. 4A). On the otherhand, the interaction of low-pH buffer-exposed Z2antibody was much less dependent on the pH of the buffer. From pH 4.5 upwards, the binding reached aplateau and became ... interferon-c (IFN-c) and other self-antigensInteractions of IVIg with cytokines and other mole-cules of the immune system have been shown to play arole in the immunomodulatory effect of the prepara-tion ... whether the IgG treatmentdescribed affected binding to a typical proinﬂammato-ry cytokine, the interactions of the native and the low-pH buffer-exposed IVIg preparations with recom-binant human...

Tài liệu Báo cáo khoa học : Bản chất của khủng hoảng kinh tế thế giới pdf

... la tien ten XHCN nhu the nao ? Nam 2005, Tdng thd'ng Hugo Chavez tuyen bd ring Venezudla se xay dflng CNXH the ky XXI, khac vdi CNXH the ky XX. Theo ong thi CNXH the ky XXI se da nguyen ... 63 KINH TE THE Gim Ban chdt cua cuoc khung hoang kinh te the gidi, cCfu vdt chu nghTa tu ban hay xay dung chu nghTa xa hoi the ky XXI DAO THE TUAN T 7" ien nay the gidi dang ... quang cao de ra gia tri tang them, khdng the dfla vao tin dung de tieu thu dfldc. Theo Maurice Allais, nha kinh te hoc Phap, giai thfldng Nobel: kinh te the gidi dfldc xay diing tjren...

Tài liệu Báo cáo khoa học:Biện chứng xã hội và công cuộc đổi mới ở nước ta hiện nay docx

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Tài liệu Báo cáo khoa học: Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT–MIM interaction pptx

... in their C-termini. Two types of MIMhave been identiﬁed: MIM1 and MIM2. The formerforms an amphipathic helix that binds to the groovebetween VPS4 MIT domain helices 2 and 3 [29,30], and the ... and pCMV3xFLAG–IST1 as a template. The ampliﬁed cDNA fragment was ﬁrst inserted into the ZeroBlunt TOPO PCR Cloning vector (Invitrogen), and the BamHI–EcoRI fragment was then inserted into the BamHI–EcoRI ... Pro-richlinker in the middle, and two different typesof MIMs (from the N-terminal side, MIM2 and MIM1, respectively) at the C-terminus.Amino acids that are important for bindingto the VPS4 MIT...

Tài liệu Báo cáo khoa học: Molecular defect of isovaleryl-CoA dehydrogenase in the skunk mutant of silkworm, Bombyx mori ppt

... human IVD. The main chains are representedby ribbons and the atoms of key residues and FAD are shown with a stick model. Helices I and J are coloured gray and the loop between the two helices ... with the neigh-bouring monomer. As shown in Fig. 7B, Tyr377 and Asn379 in the loop region interact with Leu236 and Asp234, respectively, of the neighbouring monomer via a hydrogen bond. These ... 277 (2010) 4452–4463 ª 2010 The Authors Journal compilation ª 2010 FEBS 4453 the a-hydrogen of the substrate, and the other isG374, which forms the binding pocket for the branched-chain acyl moiety...

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