Tài liệu Báo cáo khoa học: ER stress and diseases docx

... translational initiation factor 2; ER, endoplasmic reticulum; ERAD, ER- associated degradation; ERdj, ER dnaJ; ERO1, ER oxidoreductin; ERp72, ER protein 72; ERSE, ER stress response element; FKBP13, ... [144,145]. During ER stress, Bax and Bak oligomerize and activate caspase-12. Interestingly, Bax and Bak associate with IRE1a and modulate IRE1a function during ER s...

Ngày tải lên: 19/02/2014, 02:20

... (internal milieu). These are stenohaline species that can only live in either freshwater or seawater. Nonetheless, there are also numerous fish species that tolerate and even thrive in water characterized ... transduction networks and that some of them are activated more over a range of mild osmotic stress whereas others are activated more over a range of severe osmotic stress. In addi...

Ngày tải lên: 18/02/2014, 16:20

... 1). Discussion SE and oxidative stress are thought to be closely inter- related. Our findings show that GSH was reduced whereas lipid peroxidation and nitrite content were increased after SE. Lipid peroxidation ... 2 months old) were used. Ani- mals were housed in cages with free access to food and water and with a standard light ⁄ dark cycle (lights on at 07:00 h). The experiments w...

Ngày tải lên: 19/02/2014, 16:20

... for example, in+ and +ai can attach to fragments as in intern and criminal in ways that level 2 cannot *un#tern and *crimin#ness. • Stress Alternations: Stress alternations are found ... where multiple lines come together at a common vertex. One would think th~ t there ought to be 42 ways to label a vertex of two lines and 4 '~ ways to label a vertex of three line...

Ngày tải lên: 21/02/2014, 20:20

... experiment, two wells were treated with trypsin and the average cell number was deter- mined with a hemocytometer. All experiments were per- formed on several different HepG2 cell batches and, ... unlabeled ligands. Values in parentheses indicate the number of experiments performed. The data from each experiment were analyzed separately, and mean val- ues ± standard deviations were calcu...

Ngày tải lên: 14/02/2014, 14:20

... tumour necrosis factor-a and interferon (IFN)-c and an over- production of interleukin-10, and it has also been shown to bind to soluble IFN-c in a 1 : 1 complex in a manner that is independent ... pleiotropic cytokine interferon-c by the type III secretion system of Yersinia pestis. PLoS ONE 5, e15242. 92 Welkos S, Friedlander A, McDowell D, Weeks J & Tobery S (1998) V antigen of Y...

Ngày tải lên: 14/02/2014, 22:20

... t-bet, stat6 and foxp3 were also determined and found to be very simi- lar to their human homologues. Both the human and zebrafish T-bet and Foxp3 genes contained the same number of exons and introns. ... and 21 introns. This difference was found at the 3¢ end of the gene, where the zebrafish and human sequences appear to be quite diverse. Together with the well-conserved gene org...

Ngày tải lên: 16/02/2014, 09:20

... the liver and WAT. Paraffin sections of liver and WAT from WT and TG mice (S55) were stained with antibody against human H-PGDS. Bars: 100 lm. (D) PGDS activity in liver of WT and S41, S55 and S66 ... mice. Serum levels of triglyceride, glucose, leptin and insulin, and insulin sensitivity, in TG mice After 6 weeks of normal or HF diet, serum levels of triglyceride, glucose, lepti...

Ngày tải lên: 16/02/2014, 09:20

... innervation system, whereas the other nerve fiber populations are adrenergic and cholinergic in nature, and originate from paravertebral sympathetic ganglia [16]. Experimental nerve deletion and immunohisto- chemistry ... NPY receptors. Peripheral nerve fibers derived from basal, dorsal root and sympathetic ganglia innervate the bone and release NPY in the sites of innervation. Beside...

Ngày tải lên: 18/02/2014, 04:20

... assays. Reactivation of hMS by different redox states of MSR and the isolated FMN domain There is a significant thermodynamic barrier to elec- tron transfer from either the MSR FMN semiquinone (FMN sq ) ... were performed using the radioactive assay described in Experimental procedures, in which AqCbl and dithiothreitol were replaced with varying concentrations of MSR and 100 l M NADPH....

Ngày tải lên: 18/02/2014, 08:20