Tài liệu Báo cáo khoa học: Tissue factor pathway inhibitor is highly susceptible to chymase-mediated proteolysis pptx

... Pharma Limited, Japan Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor- induced blood coagulation. Human TFPI contains 276 amino acids that comprise an acidic N-terminal ... elastase on tissue factor pathway inhibitor. Blood 79, 1712–1719. 12 Petersen LC, Bjorn SE & Nordfang O (1992) Effect of leukocyte proteinases on tissue factor p...

Ngày tải lên: 19/02/2014, 00:20

... TF, tissue factor; TFPI, tissue factor pathway inhibitor; I, inhibitor; VII, factor VII; VIIa, factor VIIa; VIIa–TF, the complex of factor VIIa and tissue factor; E, enzyme; X, factor X; S, substrate; Xa, ... Hemker, H.C. & Lindhout, T. (1999) Inhibition of tissue- factor- factor VIIa-cata- lysed factor X activation by factor Xa -tissue factor pathway in...

Ngày tải lên: 22/02/2014, 04:20

... rate of tryptophan -to- NAD conversion. Rat liver ACMSD gene expression is regu- lated by the two transcriptional factors: hepatocyte nuclear factor 4a (HNF4a) and peroxisome prolifera- tor-activated ... the tryptophan pathway. Toxicol Sci 81, 302–308. 27 Shin M, Ohnishi M, Iguchi S, Sano K & Umezawa C (1999) Peroxisome-proliferator regulates key enzymes of the tryptophan-NAD pathwa...

Ngày tải lên: 19/02/2014, 02:20

... residual cofactor activ- ity, which must be further cleaved at Arg306 (k 306 )in order to completely abolish FVa cofactor activity (path- way 2, Eqn 2). Factor Va k 0 306 À! Factor Va i ð1Þ Factor Va k 506 À! Factor ... between APC and one of its inhibitors, the serpin protein C inhibitor (PCI) [17]. This is probably mediated via a template mechanism, for which binding of hepari...

Ngày tải lên: 19/02/2014, 13:20

... endothelial growth factor (VEGF) [1,2]. These factors are counterbalanced by inhibitory molecules such as a ngiostatin, endostatin, thrombospondin, and platelet factor- 4 [3–8]. Platelet factor- 4 (PF-4), ... blood ve ssels, is con trolled by positive and negative regulators. Tumours secrete potent angiogenic factors, in cluding fibroblast growth factors (FGFs), platelet-derived growth...

Ngày tải lên: 19/02/2014, 16:20

... 3660260 3660582 4357233 XP_803555.1 XP_827193.1 XP_001218860.1 Trypanosoma cruzi Protists Kinetoplasts 3 3535712 3537405 3540368 XP_805842.1 XP_807216.1 XP_809712.1 Entamoeba dispar Protists Other protists 0 – – Entamoeba histolytica Protists Other protists 0 – – Monosiga ... prokaryotes. It is well established that Sco pro- teins in eukaryotes are involved in the assembly of the Cu A cofac...

Ngày tải lên: 14/02/2014, 18:20

... although endocrine factors can impinge on its activity. Thus, the activity of ACC is an indicator of energy surplus and is thought to be one of the mechanisms by which energy homeostasis is mediated. Endocrine ... synthesis pathway. Glucose metabo- lism in the CNS en route to fatty acids gives rise to ATP and NADH, and inhibits isocitrate dehydroge- nase, thereby increasing the l...

Ngày tải lên: 14/02/2014, 22:20

... tumor necrosis factor- mediated cytolysis by overexpression of plasminogen activator inhibitor type-2. J Biol Chem 266, 20960–20964. 12 Lian X & Yang T (2004) Plasminogen activator inhibi- tor 2: ... Dickinson JL, Bates EJ, Ferrante A & Antalis TM (1995) Plasminogen activator inhibitor type 2 inhibits tumor necrosis factor alpha-induced apoptosis. Evidence for an alternate biol...

Ngày tải lên: 16/02/2014, 09:20

... determined to be 1.76 · 10 )11 m 2 Æs )1 . By relating this value to a calibrated version of Stoke–Einsteins relationship, a molecular weight of 3060 ± 90 Da is derived [28]. This value is very close to ... internaliza- tion, C-peptide enters into different cells [9–11], and into nucleoli, with intracrine effects similar to a growth factor affecting ribosomal RNA synthesis [11]....

Ngày tải lên: 18/02/2014, 04:20

... primary kinetic isotope effects. J Chem Soc Perkin Trans 2, 709–711. 55 Isaacs NS (1984) The effect of pressure on kinetic isotope effects. In Isotope Effects in Organic Chemistry (Buncel E & ... the ability to obtain isotopically pure substrates or coenzymes. One of the reasons OYEs are particularly attractive to study is the ability to create stereospecifically labelled isotopolo...

Ngày tải lên: 18/02/2014, 11:20