Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx
... mam- mals cannot synthesize folates because of the lack of three enzymes in the middle of the folate pathway, and they therefore obtain folates from the diet. DHNA is the first of the three enzymes that ... obtained by subtracting the control titration data in the absence of the enzymes from the titration data in the presence of the enzymes. The r...
Ngày tải lên: 19/02/2014, 00:20
... termination of the degradation of the enzyme [12], because the inhibition of the reaction also blocks the formation of free radicals [28]. Thus, the inactivation of the enzyme can be ascribed to the ... role in the dynamics of the peroxidase–oxidase reaction [13], and therefore they do not appear in most detailed models of the reaction. The pronounced d...
Ngày tải lên: 20/02/2014, 11:20
... modifications of the MT1- MMP ICD have also been reported with the palmitoy- lation of the cysteine 574 (C 574 ) residue [30] and the phosphorylation of the tyrosine 573 (Y 573 ) [31] and threonine ... Interestingly, mutation of the LLY 573 motif led to the detection of pro-MT1-MMP in the immunoprecipitate, sugges- ting that the disruption of the interaction...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: A novel c-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1 ppt
... A. nicotinovorans is linked to the presence of the megaplasmid, pAO1 [20]. The recent elucidation of the DNA sequence of pAO1 revealed the modular organization of the enzyme genes involved in nicotine ... mutagenesis of the MABO gene The amino acid substitutions in the MABO protein were made with the aid of the Quick Change site-directed mutagenesis kit (Stra...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: Mammalian mitotic centromere-associated kinesin (MCAK) A new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents pptx
... functions such as vesicle trans- port, chromosome segregation, and organization of the mitotic spindle. Therefore, one of the other targets of the SQAGs is probably a MCAK. We show here that SQAGs suppress ... binding. The tightness of binding may determine the degree of inhibition. SQAGs inhibit the depolymerization activity of MCAK in vivo To elucidate the MT-dep...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: "Inducing Gazetteers for Named Entity Recognition by Large-scale Clustering of Dependency Relations" ppt
... question is whether these gazetteers improve the accuracy further when they are used together. The accuracies of models that use the Wikipedia gazetteer and one of the cluster gazetteers at the same ... this further. 4.5 Effect of Combining the Cluster and the Wikipedia Gazetteers We have observed that using the cluster gazetteer and the Wikipedia one improves t...
Ngày tải lên: 20/02/2014, 09:20
Tài liệu Báo cáo khoa học: "ModelTalker Voice Recorder – An Interface System for Recording a Corpus of Speech for Synthesis" ppt
... recorded, the user rece- ives feedback on the overall quality of the utter- ance. Specifically, the user receives feedback on the pitch, the overall amplitude, and the pronuncia- tion of the recording. ... smoother, more natural sounding synthesis, but requires many hours of recording, often by a trained professional. The recording process is usually supervised,...
Ngày tải lên: 20/02/2014, 09:20
Tài liệu Báo cáo khoa học: "Word Alignment for Languages with Scarce Resources Using Bilingual Corpora of Other Language Pairs" pptx
... that the po- sition probability is independent of the position of the Chinese word and the length of the Chinese sentence. And we assume that the position probability is in- dependent of the ... (2) ml, are the lengths of the source sentence and the target sentence respectively. j is the position index of the target word. j a is the position...
Ngày tải lên: 20/02/2014, 12:20
Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
... 30821065 and 30870559 from the China National Nature Sciences Foundation, 2006CB910703 from the Ministry of Sciences and Technology of China, and 07dz05907 from the Committee of Sciences and Technology ... 15-deoxy-D12,14-prosta- glandin J2 (PGJ2), and reversed by GW9662, a PPARc antagonist. Further analysis suggests that TZDs induce the downregulation of Akt-1 and...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: It is all about resolution Meeting report based upon presentations at the 10th International Global BioMillennium 2006 symposium on molecular cell biology (Tbilisi, Georgia) docx
... In the absence of interferon, STAT2 perma- nently and rapidly shuttles between the cytoplasm and the nucleus. A region in the C-terminus of STAT2 controls its specific export in the absence of ... synchronization of cell cycle events, with one goal being the develop- ment of specific microRNA and protein signatures of particular tumor cell types, and another bein...
Ngày tải lên: 19/02/2014, 02:20