Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx

... ABC multidrug efflux pumps is assumed to correspond to the outward-facing confor- mation. The energy produced by the hydrolysis of ATP is harnessed for the resetting of the transporter to the ... Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? Christopher A. McDevitt 1 , Emily Crowley 1 , Gemma...

Ngày tải lên: 18/02/2014, 18:20

... of the PSTFS code. The task of this code is to con- catenate the first and the second name in a given list. One of the CAs is called name- concatenator. This specific CA gathers pairs of the ... 3. If a query has an answer, the result is copied to the portion of the shared heap writable by the CSA. Keep IDs on the copied TFSs. If there is no answer for...

Ngày tải lên: 20/02/2014, 18:20

... throughout the parse tree by unification. For example, values may propagate from the root node to terminal nodes, and the final form of the terminal nodes is unknown until the parser fi- nishes ... parsing for unifi- cation-based grammars has been studied by Bris- coe and Carroll (Briscoe and Carroll, 1993). Their algorithm works non-deterministically with the mechani...

Ngày tải lên: 22/02/2014, 02:20

... subtrees headed by the node A@j, and let a represent the number of subtrees headed by nodes with nonterminal A, that is a = Σ j a j . Then there is a PCFG with the following property: for every ... extract the subtrees and their relative frequencies in HC to form an STSG Zollmann and Sima’an show that the resulting estimator is consistent. But equally important...

Ngày tải lên: 20/02/2014, 12:20

... the resultant system. Because of such reasons, the data base query task was an excellent paradigmatic problem for computational linguistics, and for the very same reasons it is now time for ... should house the marketing people and vice versa" Applying the above heuristic, the bewildered system will prefer to uproot the two buildings, swap them, and lay them...

Ngày tải lên: 21/02/2014, 20:20

... in the hydrolysis of oligomeric substrates. The SBS is located too far from the active site to influence the binding and catalysis of these substrates in the active site. The same statement is ... amine group that is not abolished by the D32A mutation (Fig. 1). The acidic side chain is 3.7 A ˚ away from a hydroxyl group of the bound substrate and this dis- tance...

Ngày tải lên: 14/02/2014, 19:20

... also depends on the concentration of the reaction product and the dissociation constant K i,B for inhibitor binding. The rate of hexose-based sucrose synthesis was described by the mass action ... synthesis (r CO 2 !Suc ) was caclulated as the difference between the rate of net photosynthesis and that of net starch synthesis (unit: C 6 h )1 Æg )1 FW): r CO 2 !Suc ¼ r NetPho...

Ngày tải lên: 14/02/2014, 22:20

... to the crystal struc- ture [2,3], it is not surprising that TH8 is in the core because it is buried in the structure. Within the whole toxin, TH5 is partly covered by the C-terminal part of the ... observed within the helical hairpin TH8–TH9, which is responsible for the insertion of the T domain into the membrane. In the absence of the lipid bilayer, t...

Ngày tải lên: 16/02/2014, 09:20

... blue, and the active site is shown in red. The positive charges form three belts around the enzyme molecule, which is shown from the front (A) and the back (B). Arg217A is positioned along the extended hydrophobic ... 2010 The Authors Journal compilation ª 2010 FEBS 2489 Thus, for only two binding sites, one binding mode is responsible for partial inhibition an...

Ngày tải lên: 16/02/2014, 14:20

... transported across the cellular membrane and into the cytoplasm. This is initiated by cell surface binding of ETA to the a 2 MG ⁄ LRP1 receptor [4], which is followed by internalization of the toxin–receptor ... observations. Other studies reported that ETA translocation was strictly dependent on ATP hydrolysis but was not affected by bafilomycin, the H + -ATPase inhi...

Ngày tải lên: 18/02/2014, 04:20