Tài liệu Báo cáo khoa học: Receptor binding characteristics of the endocrine disruptor bisphenol A for the human nuclear estrogen-related receptor c pptx

... Pediatric Research Unit, CRCHUL ⁄ CHUQ, Faculty of Medicine, Laval University, Que ´ bec, Canada 2 Quebec Proteomic Center, CRCHUL ⁄ CHUQ, Faculty of Medicine, Laval University, Que ´ bec, Canada 3 Cancer ... Pozzi N, Tamasi S & Pignata C (1998) Occupancy of dipeptidyl peptidase IV activates an associated tyrosine kinase and triggers an apoptotic signal in human hepatocarcinoma...

Ngày tải lên: 19/02/2014, 07:20

... 2007 The Authors Journal compilation ª 2007 FEBS 6351 Receptor binding characteristics of the endocrine disruptor bisphenol A for the human nuclear estrogen-related receptor c Chief and corroborative ... interactions. Simultaneous mutation of these residues to Ala eliminated activity in binding to a BPA molecule, and individual mutations drastically red...

Ngày tải lên: 18/02/2014, 16:20

... pylori CCUG17874 genomic DNA using the following primers: forward, 5¢-CACCAAACCTTATACGATTGATAAGGCA AAC-3¢; and reverse, 5¢-TTATTATTGGGCGTAAGCT TCTAG-3¢. The construct was cloned directly into the pET151 ... of chain A is close to Asn77 of chain B, then Asn77 of chain A is close to Ala25 of chain B. Chain A Chain B Hydrogen bonds Ala25 Asn77, Arg80 AlaO–ArgNH1 AlaO–ArgND2 A...

Ngày tải lên: 16/02/2014, 14:20

... VgR–dsRNA1 sequence) [36] was amplified as template with primer set VgRi-f4 (5¢- TAATACGACT CACTATAGGGCGTGATCAGGTCAAAACGTATTTTC TTCATTT-3¢) and VgRi-r3 (5¢- TAATACGACTCACTATA GGGGCCACAGTCAT CCTTTT TATCG ... (5¢- TAATACGACTCACTATA GGGGCCATCTGCAATTATCAACGCCTTTCTTAACG TC-3¢) and VgRi-r1 (5¢- TAATACGACTCACTATAGGG ACCACATACTGTGCATCGCGTGAATAAGGTGTC-3¢), which included the T7 promoter region (under...

Ngày tải lên: 18/02/2014, 08:20

... CA (1981) Hypocalcaemic cataract. In Mechanisms of Cataract Formation in the Human Lens (Duncan G, ed.), pp. 219–236. Academic Press, New York, NY. 44 Duncan G & Jacob TJ (1984) Calcium and ... their function as calcium buffers because they are not expected to transduce signals as calcium sensors by conformational change upon cal- cium -binding. All b-crystallins are calcium -bindi...

Ngày tải lên: 18/02/2014, 16:20

... glutathione; DNA alkylation; acronycine; anti- cancer drug; mechanism of action. Introduction The alkaloid acronycine (Fig. 1) was first isolated from the bark of Acronychia baueri (also known as ... alkylate the genomic DNA in cells. The amount of drug–DNA covalent complexes in cells can be estimated by fluorescence meas- urements, taking advantage of the speci c fluorescence...

Ngày tải lên: 20/02/2014, 11:20

... process of the parasite infective cycle, favouring the appearance of resistant mutants which are easily spread in areas under chemotherapeutic treatments. Maslinic acid (MA) is a low toxic natural ... processes with a single compound, a new concept in antimalarial research. Introduction As long as effective vaccines against malaria remain unavailable, the search for new anti...

Ngày tải lên: 14/02/2014, 14:20

... relative decrease in the number of studies aimed at gaining an understanding of the structural conformation of chromatin, and the changes in chromatin structure that accompany gene activation. Furthermore, ... CG TF? DNMT3L Cfp1 CXXC Set1 DNMT3 Tet2 CG KDM 2A CXXC Me H3 K36 CCCCGCCCC Sp1 Pol II Set1 TAF TFIIB OH Me CG Tet2 Fig. 6. Models depicting the factors that act in concer...

Ngày tải lên: 14/02/2014, 18:20

... AGUAGUAAUGGUCC-GUCAUAAU hsa-miR-20 0c 3´ AGGUAGUAAUGGGCC-GUCAUAAU site 2: ZEB1 3´ UTR 5´ AUGCUAAAUCCGCUUCAGUAUUU ||||||| hsa-miR-200b 3´ AGUAGUAAUGGUCCGUCAUAAU hsa-miR-20 0c 3´ AGGUAGUAAUGGGCC-GUCAUAAU TGF- ... UACGAACCAUUAGAUCGAAAUA Brd-box family miRNAs K-box: 5´ cUGUGAUa |||||| dme-miR- 2a 3´ CGAGUAGUUUCGACCGACACUAU dme-miR-2b 3´ CGAGGAGUUUCGACCGACACUAU dme-miR-11 3´ CGUUCUUGAGUCUG...

Ngày tải lên: 14/02/2014, 19:20

... completed additional MS and NMR-based analysis of the cRBC glycan pool. In addition to identification and quantification of other monosaccharides, we aimed to characterize the overall sialic acid content, ... sialic acid cleavage, whereas there was the appearance of new peaks at retention times in the range 5–55 min (indicating sialic acid cleavage). Integration of the areas u...

Ngày tải lên: 14/02/2014, 19:20