Tài liệu Báo cáo khoa học: Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress pdf

... Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress M. Faadiel Essop 1,2 , W. Y. A. Chan 2 and Heinrich ... Discussion The main finding of this study is the identification of a metabolic gene switch from fatty acids to glucose in the murine female heart a...

Ngày tải lên: 18/02/2014, 16:20

... marina Mb, (d) the gene structure of the new intra- cellular circulating globin from Al. pompejana, (e) the gene structure of intracellular circulating globin from G. dibranchiata, and (f) the gene ... (proteins involved in the structure of HBL-Hb) to interact and to bind to dimers or other aggregation states while conser- ving functionality. Indeed, linkers are though...

Ngày tải lên: 19/02/2014, 02:20

... 56% of the increase in the QH 2 ⁄ Q ratio, 70% of the increase in Dw, 72% of the increase in the ATP in ⁄ ADP in ratio, and 59% of the decrease in the ATP out ⁄ ADP out ratio with succinate as ... Palmitoyl-CoA tended to increase the positive control of the ATP in ⁄ ADP in ratio by ATP synthesis and the negative control by the proton leak. The negativ...

Ngày tải lên: 19/02/2014, 05:20

... was introduced into DT40 cells. Ig-b gene expression, acetylation of H3 and H4 histones, and the remaining DHSs in the deleted cells were examined to determine the roles of these DHSs on the ... regions having transcriptional enhancing activity were found in the intergenic region between the Ig-b and GH genes. A member of the OCT family transcription factors appeared to...

Ngày tải lên: 19/02/2014, 16:20

... unex- pected flux responses that provide new insights into the behavior of the metabolic network in its entirety. Most prominently, the low in vivo activity of the Entner– Doudoroff pathway in wild-type ... histidine, isoleucine, leucine, phenyl- alanine, proline, serine, threonine, tyrosine, and valine for [U- 13 C]glucose experiments and aspartate, isoleucine, leu- cine, pheny...

Ngày tải lên: 20/02/2014, 23:20

... FEBS enabling multiple mitochondrial proteins to be released into the cytosol with cytotoxic activities [85]. The activated BH3-only protein Bad is also localized mostly in the cytosol in normal ... site for the survival function of Bcl-2 [82]. The pro-apoptotic Bcl-2 proteins relocate to the sur- face of mitochondria during apoptosis. They induce the permeabilizatio...

Ngày tải lên: 14/02/2014, 22:20

... details about the interaction, ITC was used to monitor the binding of the NarG peptides to NarJ. Surprisingly, the binding isotherm was biphasic, with the best fit obtained with a two binding site model, ... coupled to the absorption or release of protons by the protein or the ligand. If this is the case, the bind- ing enthalpy is dependent on the ionization enthalp...

Ngày tải lên: 16/02/2014, 14:20

... similar- ity) over the 132 amino acid domain C-terminal to the HD in Meis2d. We therefore suggest that the autoin- hibitory function of the Hth domain in Meis2d is likely to be a common feature ... proteins bind their cognate DNA-bind- ing site, they generally bind to other DNA-binding cofactors [10–12]. Meis2 is a member of the TALE superfamily of HD proteins, which are...

Ngày tải lên: 16/02/2014, 15:20

... with chagasin and stefin A shows that the magnitude of the shift of the occlud- ing loop is related to the size of the binding region. It is smallest in the procathepsin structures and increases in the ... cleft (Fig. 2). These additional features hinder binding along the whole interdomain interface, although they both are displaced upon binding of the ligand. The N-t...

Ngày tải lên: 18/02/2014, 04:20

... by xanthine oxidase was followed indirectly by measuring the increase in absorbance at 550 nm resulting from cyto- chrome c being reduced by superoxide in the course of the reaction. The principle ... ligands. Note that the coordinating histidines are contributed from b-strands of the central cupin barrel, suggesting a rather rigid metal-binding site. Residues in the immed...

Ngày tải lên: 18/02/2014, 06:20