Tài liệu Báo cáo khoa học: Helicases ) feasible antimalarial drug target for Plasmodium falciparum pptx

... MINIREVIEW Helicases ) feasible antimalarial drug target for Plasmodium falciparum Renu Tuteja Malaria Group, International Centre for Genetic Engineering and Biotechnology, ... developing resistance to the major antimalarial drugs. Therefore, in order to control malaria it is necessary to identify new drug targets. One feasible target might be helicases, which...

Ngày tải lên: 18/02/2014, 16:20

... relations for the auxiliary variables (1 6): β j(j+ 1) = 0 γ i(i+ 1) = 0 β j(k+ 1) ≥ β jk γ i(j+ 1) ≥ γ ij β j(k+ 1) ≥  i<j z sibl ijk γ i(j+ 1) ≥ z ij β j(k+ 1) ≤ β jk +  i<j z sibl ijk γ i(j+ 1) ≤ ... see Nivre and McDonald (200 8) for an overview. Typical graph-based methods consider linear classifiers of the form h w (x) = argmax y∈Y w  f (x, y),...

Ngày tải lên: 20/02/2014, 07:20

... Grants-in-Aid for Scien- tific Research on Innovative Areas (No.2211751 4) from the Ministry of Education, Culture, Sports, Sci- ence and Technology of Japan, by Grants-in-Aid for Scientific Research (B) (No. ... increased body weight (adiposity and ⁄ or edema), altered bone metabolism and undesir- able long-term cardiovascular outcomes (Rosiglitaz- one). For these reasons, the recentl...

Ngày tải lên: 14/02/2014, 22:20

... (TRAPs) are palmitoylated and targeted to membrane rafts (LAT, NTAL, LIME, PAG), others are found in nonraft membrane (SIT, TRIM, LAX, GAPT) [6,7]. In our opinion, the term TRAP can also be used for ... references therein). Cloning of the LAT cDNA [40,41] revealed it as a type III (leaderless) transmembrane protein of 262 amino acids (human) or 242 amino acids (mouse). A shorter human isofo...

Ngày tải lên: 18/02/2014, 04:20

... glycerol). The reactions were performed at 65 °C for 2 min. Purification steps Total protein (mg) Total activity (nmolÆmin )1 ) Specific activity (nmolÆmin )1 Æmg )1 ) Purification (fold) Yield ( %) Crude ... phosphate buffer (pH 7. 4) containing horse heart cytochrome c (0.1 m M), FNR (50 n M), Fdx (50–500 nM), and NADPH (0.5 mM)at50°C. Ratio (FNR : Fdx) 1:0 1:1 1:2 1:...

Ngày tải lên: 18/02/2014, 08:20

... 2,5-diamino-6-ribosylamino-4(3H)-pyri- midinone 5¢-phosphate ( 2) by the catalytic action of GTP cyclohydrolase II (Fig. 1) [7]. The product is transformed into 5-amino-6-ribitylamino-2,4(1H,3H)- pyrimidinedione ( 3) by ... from Bacillus subtilis. GTP as substrate Compound 10 as substrate k cat (min )1 ) K m (lM) k cat (min )1 ) K m (lM) Wild-type 2.1 ± 0.02 10 ± 1 3.0...

Ngày tải lên: 18/02/2014, 11:20

... University of Tokyo, Japan) for providing pCAG-Cre; Dr Ikuo Yana (Institute of Medical Science, University of Tokyo, Japan) for help in per- forming endothelial tube formation experiments. This work ... (Olympus, Tokyo, Japan). For immunocytochemistry, cells were fixed on ice with 4% PFA in NaCl ⁄ P i for 10 min, incubated in methanol at )2 0 °C for 20 min, and rehydrated in NaCl...

Ngày tải lên: 18/02/2014, 17:20

... Diego, CA). Fig. 1. Phage-display as a method for selecting for protein stability. Folded proteins are retained, based on the formation of the three- dimensional structure necessary to form a functional ... Streptococcal protein G (GB 1). One aspect of GB1 stability that we have addressed is the tolerance for mutations in the core of the protein. These studies provide a platform for...

Ngày tải lên: 19/02/2014, 12:20

... purposes, based on form and function rather than on word -for- word correspondence. IN HIS "A Preliminary Study of Russian", 1 Kenneth E. Harper states that a "word -for- word translation ... adequate for under- standing," since "in the field of scientific writ- ing, Russian sentence structure is definitely close to English — much closer than is normal for...

Ngày tải lên: 19/02/2014, 19:20

... PP attachment ambiguity: 1 ( 1) “At five, they closed the shop” close(they, shop); at(close, 5) ( 2) “The shop at five was closed by them” close(they, shop); at(shop, 5) The Japanese translation is ... framework: 2 The En- glish Resource Grammar (ERG; Flickinger (200 0)) is used for English parsing, and Jacy (Bender and Siegel, 200 4) for parsing Japanese. For Japanese t...

Ngày tải lên: 19/02/2014, 19:20