Tài liệu Báo cáo khoa học: SREBPs: SREBP function in glia–neuron interactions pdf

... protein ratio. The myelin membrane contains myelin-specific proteins, such as myelin pro- tein zero, peripheral myelin protein-22, myelin asso- ciated glycoprotein (MAG) and myelin basic protein, but ... SREBPs are also involved in neurological dis- eases. Here, we discuss the current understanding of the role of SREBPs in glia–neuron interactions in health and disease. Role of Schwa...

Ngày tải lên: 18/02/2014, 13:20

... representing default information, which we refer to as the 'main' equation set. These may be overridden by eontlleting information in a more specific class. Each equation in a main set functions ... affecting individual words and subclasses of words. These considerations have provoked interest in applying to the lexicon AI knowledge representation techniques involving...

Ngày tải lên: 20/02/2014, 21:20

... IRS-2, insulin receptor substrate-2; PUFA, polyunsaturated fatty acid; SCAP, sterol regulatory element-binding protein cleavage-activating protein; SREBP, sterol regulatory element-binding protein. 616 ... focusing on the molecular mechanisms by which SREBPs are involved in lipotoxicity. SREBPs directly repress the transcription of insulin receptor substrate-2 (IRS-2), the main insulin sig...

Ngày tải lên: 18/02/2014, 13:20

... acids found in many proteins involved in protein–protein interactions. The WD repeat domain is the region of SCAP that forms a complex with the C-terminal domain of SREBPs [4]. When cells Keywords ATF6; ... highly induced in response to short-term high-fat feeding in mice. PGC-1b interacts with SREBPs, thereby inducing a broad program of lipid metabolism, including de novo lipogenesi...

Ngày tải lên: 18/02/2014, 13:20

... GS staining (B3), and 4¢,6-diamidino-2-phenylindole (DAPI) staining (B4), respectively. (B5-8) High magnification images of the boxed area in (B4) showing RPE65c staining (B5), GS staining (B6), ... process involving multiple enzymes and retinoid-binding pro- teins between photoreceptors and retinal pigment epi- thelium (RPE); it is essential for maintaining normal vision [3,4]. The key step...

Ngày tải lên: 14/02/2014, 14:20

... protein kinase; MCF, macrophare chemotactic factor; MCIP, modulatory calcineurin-interact- ing protein; MDCK, Madin Darby canine kidney; MEF, mouse embryonic fibroblast; MEK, MAP kinase/ERK kinase; ... glycogen synthase) is insufficient to accurately explain insulin-stimulated changes in the concentration of intracellular species and partitioning of glucose disposal in skeletal muscle. Insu...

Ngày tải lên: 14/02/2014, 14:20

... that tau interacts with Fyn-SH2. Proteins harbouring SH2 domains bind to phosphorylated tyrosines on their tar- get proteins, thereby coupling the activity of tyrosine kinases with intracellular ... possibly independent, mech- anisms are involved in these interactions of tau with the same protein. Interactions with Fyn-SH3 are regulated by key PXXP motifs in tau Tau has been shown to...

Ngày tải lên: 14/02/2014, 14:20

... modification and are maintained in a constitutively active state by CXXC domain proteins that bind to non-methylated CG sequences. These proteins include MLL1 and the CG-binding protein Cfp1 that itself ... intrinsic cooperativity in the binding of transcription factors to nucleosomes [238–240]. Even in the absence of pro- tein–protein interactions, factors can assist each other’s bindi...

Ngày tải lên: 14/02/2014, 18:20

... tyrosine kinases. In 1993, loss-of -function mutations in the BTK gene were reported as the cause of X-linked agammaglobulinemia. Of all the existing 90 tyrosine kinases in humans, Bruton’s tyrosine ... signaling proteins carrying domains also found in BTK. In 2009, an inactivating mutation in the ITK gene was shown to cause susceptibility to lethal Epstein–Barr virus infec- tion...

Ngày tải lên: 14/02/2014, 18:20

... observable. Interestingly, the RMI1 mRNA level increased signifi- cantly in the liver and intra-abdominal fat of the obese phenotype mice; however, that in the skeletal muscle did not increase, and that in ... the Bloom’s syndrome gene helicase complex that maintains genome integrity and activates cell-cycle checkpoint machinery. Interestingly, diet-induced expression of E2F8 mRNA, which...

Ngày tải lên: 16/02/2014, 09:20