Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt

... MINIREVIEW SREBPs: physiology and pathophysiology of the SREBP family Hitoshi Shimano Department of Internal Medicine (Endocrinoglogy and Metabolism), Graduate School of Comprehensive Human ... a direct target of SREBP [20]. The role of SREBP- 1a in the regulation of cell growth and the cell cycle might be biphasic and complex, and needs to be furthe...

Ngày tải lên: 18/02/2014, 13:20

... expression of T-bet has been seen within a wide variety of tissues and cells in the Ginbuna crucian carp [27] and, in mammals, in the lung tissue of mouse and spleen and thymus of human and mouse ... end of the gene, where the zebrafish and human sequences appear to be quite diverse. Together with the well-conserved gene organization, there is a conservation of...

Ngày tải lên: 16/02/2014, 09:20

... analysis of the topological modules of the Fig. 3 (labelled A–G) shows that they include structural and ⁄or functional features. Table 3 summarizes the main structural and functional features of these groups. ... [50]. Group F contains 90% of the members of the nuclear receptor hormone superfamily of the HTFN (they also are Zn finger pro- teins) [26]. In these group...

Ngày tải lên: 19/02/2014, 07:20

... that the data were described best by a two-binding site model. The IC 50 (the concentration of the competing ligand that inhib- its 50% of the specific binding of [ 125 I]TC-PCSK9) val- ues for the ... higher-affinity and lower-affinity binding sites are listed in Table 1. The high-affinity and the low-affinity sites accounted for 25% and 75% of the total binding, r...

Ngày tải lên: 14/02/2014, 14:20

... performed and the P-values are displayed, as calculated using the Student’s t-test. The mean and standard deviations of absolute numbers of the observed colonies are indicated. (C) Number of colonies ... [19]. The Rho family of small G proteins represents a large group of the Ras superfamily of GTPases. More than 20 proteins of this class have been described to...

Ngày tải lên: 16/02/2014, 15:20

... Y5 and y6) that vary in their binding profiles and in their distribution in the central nervous system and periphery. Y1, Y2 and Y5 are the best characterized NPY receptors, and the majority of ... stromal cells and osteoblasts [40,46–48], despite the absence of the other Y receptors (Y2, Y4, Y5 and y6) [40,46]. In addition to the presence of NPY-immunoreactive...

Ngày tải lên: 18/02/2014, 04:20

... number of these modifications is low, the density of modifications is much the same as in the rest of the lin- ker histones. It is the shortness of the N-terminal tails Table 1. Alignment of chicken, ... studies [14–16] suggest that the linker histone is close to the dyad axis of the core particle at the entry and exit of the DNA. Similarly, the geometry...

Ngày tải lên: 18/02/2014, 08:20

... organelle and membrane proteins are synthe- sized and folded with the assistance of molecular chap- erones and other folding factors in the endoplasmic reticulum (ER). In many cases, the process of ... GmPDIL-3a and GmPDIL-3b were detected at a density of 1.21 gÆmL )1 in the presence of MgCl 2 . In the presence of EDTA, which releases ribosomes from the rough ER...

Ngày tải lên: 18/02/2014, 11:20

... localization signal and a DNA-binding domain in the MH1 domain and the L3 loop, and the C-terminal, receptor phos- phorylation motif in the MH2 domain (Fig. 1A). The amino acid composition in the L3 loop of R-Smads provides ... of cellular media- tors called receptor-regulated Smads (R-Smads). The R-Smads of the TGF b–activin pathway include Smad2 and Smad3. The...

Ngày tải lên: 18/02/2014, 16:20

... determination The reaction mixtures were as in the standard assay, except that the components specified in the Results were added, and the concentrations of the substrate and enzyme varied as required for the ... independently evaluate the effects of ionic strength and Mg 2+ on the activity and specificity of OGG1, we measured the apparent values of k 2 and...

Ngày tải lên: 18/02/2014, 18:20