Tài liệu Báo cáo khoa học: Structure of RNase Sa2 complexes with mononucleotides – new aspects of catalytic reaction and substrate recognition pptx

... superposition. RNase No. of corresponding CA atoms rmsd (A ˚ ) RNase Sa2 ⁄ RNase Sa 90 0.76 RNase Sa2 ⁄ barnase 62 1.19 RNase Sa2 ⁄ binase 62 1.19 RNase Sa2 ⁄ RNase T1 47 1.80 Structures of RNase Sa2 mononucleotide ... understand the mechanism of RNA cleavage and differences in the catalytic prop- erties of the two RNases, we have solved the structures of...

Ngày tải lên: 18/02/2014, 11:20

... enrichment of AcH4-K16 within transcribed genes is closely correlated with binding of both MOF and Tip60 (equivalent to Esa1 in yeast NuA4) [124,130]. However, in human cells depletion of MOF, but ... acetylation and deacetyla- tion, and transient recruitment of remodellers and transcription factors. A cycle of transcription commences with the recruit- ment of transcri...

Ngày tải lên: 14/02/2014, 18:20

... & Sander C (1983) Dictionary of protein secondary structure – pattern -recognition of hydrogen- bonded and geometrical features. Biopolymers 22, 257 7– 2637. 20 Holm L, Ouzounis C, Sander C, ... atoms of residues 2–1 44 (N-domain) 1.12 ± 0.19 Heavy atoms of residues 2–1 44 (N-domain) 1.65 ± 0.16 Backbone atoms of residues 15 3–2 97 (C-domain) 0.69 ± 0.10 Heav...

Ngày tải lên: 18/02/2014, 14:20

... (1990) The structure and function of the aspartic proteinases. Annu. Rev. Biophys. Biophys. Chem. 19, 18 9–2 15. 2. Dunn, B.M. (2002) Structure and mechanism of the pepsin-like family of aspartic ... isoforms by the excision of the prosegment and of most of the PSI [21]. Conversely to what has been found in vivo [31], heavy and light chains of the processed forms...

Ngày tải lên: 19/02/2014, 12:20

... methods and the structures overlay very closely [1 3–1 5]. Despite the small size of a-conotoxins they have well- defined structures with a characteristic overall fold. With the structures of more ... between 3.0 and 6.0 and all were of high precision, with backbone rmsd values between 0.34 A ˚ and 0.78 A ˚ . Two different structures of MII have also been published. One...

Ngày tải lên: 19/02/2014, 12:20

... self-assembly of the envelope glycoprotein of ASLV bound to membrane. Effects of pH on the secondary structure and membrane interaction of IFP–wt Based o n studies on the molecular clustering of EnvA ... in SDS micelles of IFP–wt. Fig. S2. Comparison of the chemical shift deviation a nd coupling constant results between IFP–wt and IFP( 8–4 4) allows examination of the...

Ngày tải lên: 19/02/2014, 16:20

... 2002 Structure of peptidase T (Eur. J. Biochem. 269) 447 Substrate binding Structural investigation of enzyme±ligand complexes is usually one of the most useful m ethods for obtaining an understanding ... are showninblueiftheybelongtothecentral b sheetofthecatalyticdomain,greenifthey belong to the four-stranded bsheetofthe dimerization domain, and ligh t blue if they belong the...

Ngày tải lên: 21/02/2014, 03:20

... causing activation of Bax and Bak [23]. Regulation of Bcl-2 family members can occur by a number of mechanisms, including up-regulation of synthesis, enhancement of degrad- ation and phosphorylation. ... activation of Akt and to Ser184 phosphorylation of Bax [46]. This phosphorylation promotes the seques- tration of Bax in the cytoplasm and increases the abil- ity of...

Ngày tải lên: 16/02/2014, 09:20

... spec- trometer with an inverse broadband probe installed with z-gradient. The 1D spectra 1 H and 13 C; the homonuclear 2D spectra DQF-COSY, TOCSY, NOESY and ROESY; the 1 H– 3 C HSQC and HMBC; and the 1 H– 15 N ... congruent with the structure of eryth- rochelin (Fig. S18). The domain organization and the predicted substrate specificities of the A-domains do not reflect i...

Ngày tải lên: 16/02/2014, 09:20

... minimal. Morphological evidence of the antiapoptotic effect of HSS As shown in Fig. 2A,B, the treatment of cells with 50 lm CCCP induced profound changes in the nuclear morphology of hepatoma cells, with chromatin ... Bloom SE (2003) Reversal of Bcl-2-mediated resistance of the EW36 human B-cell lymphoma cell line to arsenite- and pesticide-induced apoptosis by PK11195, a li...

Ngày tải lên: 16/02/2014, 09:20