Tài liệu Báo cáo khoa học: Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase–methionine synthase reductase complex docx

... 2009 The Authors Journal compilation ª 2009 FEBS 1951 Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase methionine synthase reductase complex Kirsten ... 490– 500. 19 Wolthers KR & Scrutton NS (2007) Protein interactions in the human methionine synthase methionine synthase reductase c...

Ngày tải lên: 18/02/2014, 08:20

... schematically depicted and the binding epitope for the anti-EpoR immunoglobulin is indicated. The calibrator, GST-EpoR, consists of the protein domain containing the antibody-binding site fused to ... weak affinity to the protein, cross-reaction with other proteins resulting in a high background, or by the use of generic phosphotyrosine antibodies. In such cases, the...

Ngày tải lên: 19/02/2014, 07:20

... that the inference of the user’s overall intention via DA detection is an important task in SDS. Figure 1 depicts the training and test phases of the SLU module and the DM module in our system. The ... (DAs), counting the occurrences the DRs in DA, and intro- ducing an entropy-based weighting scheme (Belle- garda, 2000). This matrix is pivotal in the computa- t...

Ngày tải lên: 20/02/2014, 05:20

... contains one gene (AF500) for which no corresponding protein was found in the purified enzyme preparation. The results of the sequence analyses of the deduced proteins are given in Table 2. The protein ... DsrK, and HmcF clearly identified the t wo typical CXXCXXCXXXCP binding motifs for [4Fe-4S] clusters in the N-terminal part of these proteins. AF502, DsrK, and Hmc...

Ngày tải lên: 21/02/2014, 03:20

... 2B,C, insets), suggesting the presence of two binding sites ⁄ states. The K d values obtained for the higher-affinity and lower-affinity binding sites are listed in Table 1. The high-affinity and the ... lipo- proteins, and there was a corresponding increase in the binding of [ 125 I]TC-PCSK9 and [ 125 I]TC-PCSK9- D374Y. Second, the extent of specific binding of both [...

Ngày tải lên: 14/02/2014, 14:20

... explanation for the fact that certain in u- enza strains do not agglutinate cRBCs, using specific human-adapted in uenza hemagglutinins as examples. Finally, recent understanding of the role of various ... virus (or infectious) particles and assays that measure the binding of a virus particle to a cell, representative of the first step in the infection cycle. In the former...

Ngày tải lên: 14/02/2014, 19:20

... assembly. In the first model, both hydrophobic translocators exist in oligomeric form, with the major partner inserted stably into the membrane, whereas the minor protein is the link with the V antigen. ... the V antigen The third component of the translocation apparatus is a hydrophilic protein: PcrV in P. aeruginosa, LcrV in Yersinia spp, IpaD in Shigella and...

Ngày tải lên: 14/02/2014, 22:20

... below. Synchronous increases in intracellular [Ca 2+ ] and disassembly of cadherin–catenin complexes The cytoplasmic domain of cadherin interacts with F-actin via b-catenin and a-catenin; b-catenin binds to ... change in cell–cell adhesion that is mediated by cadherin–catenin complexes within each cell and by cadherin–cadherin interactions between the two cells. The interkin...

Ngày tải lên: 16/02/2014, 09:20

... all-alpha domain, STAT protein DNA-binding domain and SH2 domain of stat6, and the zinc-finger domain, leucine-zipper domain and fork-head domain of foxp3. In addition, for stat6 and foxp3, there were ... strengthens interactions between STAT dimers on adjacent DNA-binding sites, a coiled-coil STAT protein all-alpha domain, which is implicated in other protein protein in...

Ngày tải lên: 16/02/2014, 09:20

... adi- pogenesis and increased insulin sensitivity. The present study provides the first evidence that PGD 2 participates in the differentiation of adipocytes and in insulin sensitivity in vivo, and the H-PGDS ... H-PGDS, hematopoietic prostaglandin D synthase; IBMX, 3-isobutyl-1-methylxanthine; L-PGDS, lipocalin-type prostaglandin D synthase; LPL, lipoprotein lipase; PG, p...

Ngày tải lên: 16/02/2014, 09:20