Tài liệu Báo cáo khoa học: a-Defensins increase lung fibroblast proliferation and collagen synthesis via the b-catenin signaling pathway doc

... among lung fibroblasts. Inhibition of the b-catenin signaling pathway using quercetin blocked the a-defensin-induced increase in lung fibroblast proliferation and collagen synthesis To investigate the ... compilation ª 2009 FEBS a-Defensins increase lung fibroblast proliferation and collagen synthesis via the b-catenin signaling pathway W...

Ngày tải lên: 18/02/2014, 06:20

... chromatography and subsequent throm- bin cleavage [41]. The use of thrombin significantly increases the cost of the purification, and the require- ment for HPLC increases the length and complexity of the ... 5¢-CCTGCCGAGCTCCTATTA CACAACGCCACCAACCATCAG-3¢. The PCR solution was prepared in the buffer supplied with the enzyme, and contained Aba, Abb and Abcat 40 nm each...

Ngày tải lên: 18/02/2014, 13:20

... malignancies. One of the most prevalent primary cellular defence mechanisms against chemotherapeutic agents is the membrane- bound transporter [1]. The defining feature of these transporters is their ability ... specificity compared with other multidrug trans- porters. In particular, the protein confers resistance to the anticancer drugs mitoxantrone [17], methotrexate [18] and the...

Ngày tải lên: 18/02/2014, 18:20

... consumption and to examine the possible role played by cells and mole- cules of the immunological system in hepatic injury and repair. Understanding the interdependence between the metabolism of iron and ... localizes in the cytoplasm of human epithelial cells of the gastrointestinal tract and liver, two central organs in the regulation of iron metabolism [20,21]. Afte...

Ngày tải lên: 19/02/2014, 16:20

... nervous system injury, and reducing the biosynthesis of ICAM-1 and other cytokines by blocking the cell signal pathway might provide a new strategy against inflammatory and immune reaction after peripheral ... expression via activation of the JNK pathway and activator protein-1 [45], the pres- ent research suggests that the JNK pathway also plays a significant role in...

Ngày tải lên: 18/02/2014, 18:20

... individuals with mild disease, thereby providing the missing data. The phenotype of XLA and the potential of BTK and ITK inhibitors The outcome of defective BTK signaling in humans has been described ... COS7 and 293T cells and did not vary like BTK–SYK; therefore, the differences in the PH–TH domains remain the decisive factor for this variation. The B-cell adapter...

Ngày tải lên: 14/02/2014, 18:20

... metalloenzyme that catalyzes the dehydra- tion of 2-phospho-d-glycerate to phosphoenolpyruvate in the second half of the glycolytic pathway. In the reverse reaction (anabolic pathway) , which occurs ... involved in the synthesis of pyru- vate. It also acts as a plasminogen receptor and thus mediates activation of plasmin and extracellular matrix degradation. In tumor cells,...

Ngày tải lên: 14/02/2014, 19:20

... PDGFRA and T670I in KIT) [27–29]. The conserved threonine residues in these different kinases are located near the kinase active site and appear to be critical for the binding of ATP and the corresponding ... genotype-directed therapy in this disease. KRAS mutation as a mechanism of resistance to EGFR-targeted therapy The KRAS protein is localized to the inner surface of th...

Ngày tải lên: 16/02/2014, 09:20

... protection, define the core of the protein’s N state [21]. For the T domain, these were the center of TH5 and TH8, and the N-terminal half of TH9. All a-helices (TH1, 3, 4, 5’, 6, 7 and the remaining ... highlighting the regions of the protein with either higher stability and ⁄ or lower accessi- bility to the solvent. The regions exhibiting the lowest exchange (be...

Ngày tải lên: 16/02/2014, 09:20

... with the modifiers separately and then in various combinations of concentrations. In the case of the sulfated polysaccharides, the effector molecules are constituents of the same sample, and their ... Equation (1) was fitted to the data, and the solid lines represent the best fit. Parameters from regression analysis are shown together with their standard errors in (A–D). T...

Ngày tải lên: 16/02/2014, 14:20