Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx

... having sufficient power are therefore extremely important in minimizing the in uence of confounding factors arising from inherent problems associated with breeding APP transgenic mice and maintaining ... time-consuming and greatly in uenced by individual handlers. IntelliCages are automated learning cages where animals carrying transponders are housed in groups and trained in learnin...

Ngày tải lên: 16/02/2014, 09:20

... not repress the level of PPARc protein in committed prea- dipocytes under physiologically relevant conditions. Expression of miR-27 is elevated in obese mice In order to gain insights into the potential ... We further investigated the kinetics of miR-27 expression during adipogenesis using quantitative real-time PCR. As shown in Fig. 1C,D, expression of both miR-27a and miR-27...

Ngày tải lên: 18/02/2014, 08:20

... interact with a number of functional groups, including the aromatic side chains of some amino acids, through a stacking mechanism [42]. The interaction of arginine with aromatic amino acids of aB-crystallin ... of insulin. A C B Fig. 2. aB-crystallin protects against the DTT-induced aggregation of insulin, and this activity is enhanced by Arg-HCl. Insulin ( , 0.25 mgÆmL )1 ) was i...

Ngày tải lên: 18/02/2014, 16:20

... strong, neutralizing action of the cytosolic RNase inhibitor (cRI), a 50-kDa protein containing 16 leu- cine-rich repeat motifs [7,8]. In fact, onconase from Rana pipiens eggs [9], and seminal RNase ... of EIE were recorded at 30° inter- vals of r from 0 to 360°; (d) the inclination of the dimer major axis with respect to the z axis, hence to the membrane plane, was changed (by incl...

Ngày tải lên: 19/02/2014, 06:20

... extension to the protein kinase folds back on the kinase domain and interferes with the substrate binding sites. In the case of the titin and twitchin kinases, the autoinhibitory sequence acts ... hexadecameric enzyme consisting of four copies of four subunits: (abcd) 4 . An intrinsic calmodulin (CaM, the d subunit) binds directly to the c protein kinase chain. The interaction site o...

Ngày tải lên: 19/02/2014, 17:20

... evidence that N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT1 to GABA. Transport of GABA by GAT1 across ... blotting. Either anti- GFP mAb MAB2510 or anti-GAT1 pAb was used for the immunostaining. The protein bands obtained in western blotting were analyzed by phosphoimager scanning. The to...

Ngày tải lên: 19/02/2014, 17:20

... Linguistics Improving Classification of Medical Assertions in Clinical Notes Youngjun Kim Ellen Riloff Stéphane M. Meystre School of Computing School of Computing Department of Biomedical Informatics ... recall gains on the minority classes. 1 Introduction Since the beginning of the new millennium, there has been a growing need in the medical community for Natural...

Ngày tải lên: 20/02/2014, 05:20

... Proceedings of the 47th Annual Meeting of the ACL and the 4th IJCNLP of the AFNLP, pages 324–332, Suntec, Singapore, 2-7 August 2009. c 2009 ACL and AFNLP 1

Ngày tải lên: 20/02/2014, 07:20

... to domains in which large amount of reviews are not available. In addition, the corpus created from re- views is often noisy as we discuss in Section 2. This paper proposes a novel method of building polarity-tagged ... follows in Section 4. In Section 5, we discuss experimen- tal results, and in Section 6 we examine related works. Finally we conclude in Section 7. 2 Corpus...

Ngày tải lên: 20/02/2014, 12:20

... eosin staining. We examined the expres- sion of these proteins in a cancer-free layer of squamous epithelial cells, carcinoma in situ (CIS) and invasive cancer, all of which were observed in ... detected not only in total cellular proteins but also in chromatin-bound proteins. The Mcm proteins bound to chromatin probably function in DNA replication, but the role of the pro...

Ngày tải lên: 20/02/2014, 23:20