Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx

... domain of the EGFR induces receptor dimeriza- tion, activation of the intracellular kinase domain and autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptor. The tyrosine- phosphorylated ... epidermal growth factor receptor (EGFR) is com- posed of an extracellular ligand-binding domain, a transmembrane domain and an intracellular tyrosine...

Ngày tải lên: 16/02/2014, 09:20

... grouped into three main classes of PDZ binding motifs, occurring at the C-terminus of the interacting proteins [16]. We scanned the human olfactory receptor repertoire for putative binding motifs ... repertoire and discovered that up to 30% of receptors contain putative PDZ binding motifs in their C-termini, following the previ- ously outlined rules of binding [16]. PDZ domains...

Ngày tải lên: 18/02/2014, 13:20

... transient receptor potential channel protein (TRPC1) (amino acids 271–349) contains a Caveolin-1-binding motif between amino acids 322 and 349. Deletion of this binding domain altered localiza- tion of ... labeling electron microscopy of P2X 7 in alveolar epithelial E10 cells Immunogold labeling of P2X 7 receptors expressed in E10 cells was performed to analyze the subcell...

Ngày tải lên: 19/02/2014, 00:20

... NirF Interestingly, like NirN, NirF shares sequence similar- ity with the C-terminal d 1 heme-containing domain of cytochrome cd 1 . Strikingly, the axial ligand of iron in d 1 heme in P. pantotrophus ... and of the kanamycin insertion mutant nirF strain (SBN03) in the upper right panel. Growth of SBN11 (DnirF) is shown in the bottom left panel and of SBN13 (DnirF) containin...

Ngày tải lên: 15/02/2014, 01:20

... (2008) Mapping alpha-helical induced folding within the intrinsically dis- ordered C-terminal domain of the measles virus nucleo- protein by site-directed spin-labeling EPR spectroscopy. Proteins 73, ... (2010) Solution structure of the C-terminal X domain of the measles virus phosphoprotein and interaction with the intrinsically disordered C-terminal domain of the nucleoprotein. J Mo...

Ngày tải lên: 18/02/2014, 04:20

... Seurin D, Segovia-Quinson B, Hardouin S & Binoux M (1986) Analysis of serum insulin-like growth factor binding proteins using western blotting: use of the method for titration of the binding ... residing in the heart of the IGF-II binding domain in repeat 11 disrupts IGF-II binding to the receptor [22,31–33]. The ligand blotting data shown in Fig. 1C confirm that the wild...

Ngày tải lên: 18/02/2014, 08:20

... neighboring cells, and their cytoplasmic com- ponents are linked to accessory proteins (e.g. zonula occludens proteins and cingulin), forging a connection to the actin cytoskeletons of endothelial cells ... and gamma-catenins in their cytoplamic tails. As with tight junctions, adherens junctions are linked to the actin cytoskeleton via the binding of beta- and gamma-cate- nin...

Ngày tải lên: 18/02/2014, 11:20

... in the human genome. In addi- tion, VEGF-E encoded in the Orf virus binds and activates only VEGFR-2. Anti-(VEGF-A) IgG and aptamer, as well as VEGFR tyrosine kinase inhibitors (multikinase inhibitors) ... tyrosine kinase. VEG- FR-2 tyrosine kinase has a strong kinase activity simi- lar to epidermal growth factor receptor (EGFR), but the signaling pathway towards pro...

Ngày tải lên: 18/02/2014, 11:20

... protein kinase c-Jun N-terminal kinase (JNK) pathway is known to trigger many cell death pathways including caspases, and many studies have shown that JNK inhibitors are neuroprotective in rodent ... metalloproteinases, their inhibitors, and laminin in stroke patients: in uence of different therapies. Stroke 34, 2165–2170. 26 Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A,...

Ngày tải lên: 18/02/2014, 11:20

... composed of EIIA, B and C domains, with the EIIA and B do- mains being part of the phosphorylation chain and the EIIC domain representing the membrane domain. As all components of the PTS, depending ... concentrations as a result of altered glycolytic fluxes. Neglecting this important input into the PTS restricts the changes in the degree of phosphorylation of PTS proteins to c...

Ngày tải lên: 18/02/2014, 13:20