Tài liệu Báo cáo khoa học: MicroRNAs and epigenetics doc

... the authors. F. Sato et al. MicroRNAs and epigenetics FEBS Journal 278 (2011) 1598–1609 ª 2011 The Authors Journal compilation ª 2011 FEBS 1609 MINIREVIEW MicroRNAs and epigenetics Fumiaki Sato 1 , ... [36]. Fig. 1. Epigenetics miRNA regulatory circuit. Epigenetics and miRNAs regulate whole gene expression pattern transcriptionally and post- transcriptionally, respectively....

Ngày tải lên: 14/02/2014, 19:20

... that thousands of human genes are microRNA targets. Cell 120, 15–20. 11 Sato F (2011) Epigenetics and miRNA. FEBS J 278, 1598–1609. 12 Olson EN (2006) Gene regulatory networks in the evolution and ... 381, 597–601. MicroRNAs and cardiovascular diseases K. Ono et al. 1630 FEBS Journal 278 (2011) 1619–1633 ª 2011 The Authors Journal compilation ª 2011 FEBS 58 Rowland RT, Meng X, Cleve...

Ngày tải lên: 14/02/2014, 19:20

... Carbohydrate, glycolysis Lactococcus lactis Modeling Pi explicitly and regulation of pyruvate kinase (by Pi and FBP), PFK (by PEP) and GAPDH (by NADH) are critical to describe observations (rapid increase in PEP, Pi and gradual decrease ... metabolite concentrations and metabolic fluxes, both measured and nonmeasured. A general parameter sensitivity analysis is carried out to deter...

Ngày tải lên: 14/02/2014, 14:20

... H4-K5, K8 and K12 acetylation [136–138]. In yeast, this group is made up of NuA4 and Piccolo NuA4 which both uti- lize Esa1 as the HAT, and Esa1 was found to be essen- tial for H4-K5, K8 and K12 ... acetylation and deacetyla- tion, and transient recruitment of remodellers and transcription factors. A cycle of transcription commences with the recruit- ment of transcription factor...

Ngày tải lên: 14/02/2014, 18:20

... tumors and cell lines, miR-17- 5p and miR-20a are induced in a manner that depends on cyclin D1 and repress the expression of cyclin D1. Hence, miR-17-5p ⁄ 20a and cyclin D1 form a feedback loop and ... transcription factors E2F and Myc but, in turn, miR-17-92 downregulates the expression of E2F and Myc [52]. In tumor progression, the tran- scription repressors ZEB1 and SIP1...

Ngày tải lên: 14/02/2014, 19:20

... binding and cleav- age by ribonuclease A and variants at Lys7, Arg10, and Lys66. Biochemistry 37, 12121–12132. 31 Anderson DG, Hammes GG & Walz FG Jr (1968) Binding of phosphate ligands to ... where I i (h) and I(h) are the ith and the mean measurements of the intensity of reflection h, respectively. R cryst = R h |F o ) F c | ⁄ R h F o , where F o and F c are the observed and...

Ngày tải lên: 14/02/2014, 22:20

... activation site (R144, N154, I152) and three in the second (F127, M436 and H428), and found that Ap 4 A and ADP interact with the same site, but the sites for ATP and BPG remain uncertain. The structural ... cN-II, cN-III, cN-IA and cN-IB, and both cytosolic and mitochondrial 5¢(3¢)-deoxyribonu- cleotidases [5]. Even though all soluble 5 ¢-nucleotidases share the same reaction...

Ngày tải lên: 15/02/2014, 01:20

... HPRT and hypoxanthine. (C) PRTFDC1 and guanine. (D) HPRT and guanine. Table 2. K m and V max values for Hx and G in the presence of 1 mM PRPP, determined using the DE-81 filter paper assay and ... domain is mainly built up by residues from the C-terminus and consists of a two-stranded anti-parallel b-sheet composed of b2 and b9 and an a-helix from the C-terminus (Fig. 1A). Th...

Ngày tải lên: 15/02/2014, 01:20

... ferre- doxins, Fd1 and Fd2, from this bacterium are considered to serve as low-potential electron donors for this key reaction [8]. POR is distributed among archaea, bacteria and anaerobic protozoa, and is ... phylogenetically related and the heterotetra- meric enzyme has been proposed to be the common ancestor that underwent gene rearrangement and fusion to generate homo- and het...

Ngày tải lên: 16/02/2014, 09:20

... presence and absence of IL-10. *P < 0.05 and **P < 0.01 versus Cont group. (D) Representative western blots for collagen I and III in the presence and absence of 0.1 l M angiotensin II and IL-10. Paracrine ... proliferation and collagen synthesis (Fig. 1B). Hypoxia ⁄ SD induces NF-jB-dependent IL-1b and TNF-a transcription Because transcription of IL-1b and TNF-a can be...

Ngày tải lên: 18/02/2014, 04:20