Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc

... (2000) Nucleated conformational conversion and the replica- tion of conformational information by a prion determi- nant. Science 289, 131 7–1 321. 99 Wood SJ, Wypych J, Steavenson S, Louis JC, Citron M & ... and amyloid fibril formation FEBS Journal 278 (2011) 226 3–2 282 ª 2011 The Authors Journal compilation ª 2011 FEBS 2281 REVIEW ARTICLE Mechanisms of amyloid fibri...

Ngày tải lên: 14/02/2014, 18:20

... the kinetics of fibril formation of these oxidized proteins reveal the amino acid inter- actions that are critical in the onset of amyloido- genesis. The rates of amyloid fibril formation for WT and V30M ... the onset of amyloid fibril formation. Alternatively, the inhibition of fibril formation may purely be the result of an increase in solubility of o...

Ngày tải lên: 19/02/2014, 05:20

... amyloid A [2 1–2 8] (Fig. 1). Adipokines are considered to facilitate mono- cyte adhesion and migration into the vascular wall and the conversion of monoctyes to macrophages. Increased levels of ... dysfunction and on features of the metabolic syndrome. Andrologia 40, 4 4–4 8. 110 Saad F, Gooren LJ, Haider A & Yassin A (2008) A dose-response study of testosterone on sexu...

Ngày tải lên: 18/02/2014, 06:20

... appearance of kinase activity in those samples. The level of depletion of kinase activity mirrored the level of depletion of C-YES, indicating that C-YES contributes a large fraction of the Y17 kinase ... phosphory- lation of this site is important for integrity of the G1 checkpoint [13]. Phosphorylation of CDK4 on Y17 has also been detected in cells entering quiescence in...

Ngày tải lên: 18/02/2014, 18:20

... closed P-loop conformation is stable over a broad ionic strength range. Structure of PhyAsr upon oxidation of the catalytic cysteine A systematic comparison of the open P-loop confor- mation in PhyAsr ... conformation, and results in the formation of two hydrogen bonds with the main chain carbonyl oxygen of Gly257 and O d 3of the oxidized cysteine. This conformation of Thr259...

Ngày tải lên: 18/02/2014, 18:20

... representative of the results obtained, regardless of the experimental condition s or of the presence of T800 and the regulatory proteins Tm–Tn. The filament motion displayed a ccele ration/decel- eration ... on the Ca 2+ -linked regulation of the actin–HMM ATPase is entirely consistent wit h the la ck o f effect on the Ca 2+ -controlled on/ off switch of thin fi lament motion....

Ngày tải lên: 19/02/2014, 16:20

... regulation of the cytochrome c oxidation–reduction equilibrium. Biochemistry 28, 318 8–3 196. 41 Zhou H-X (1994) Effects of mutations and complex for- mation on the reduction potentials of cytochrome ... determination of midpoint potentials of oxidation–reduction compo- nents of biological electron-transfer systems. Methods Emzymol 54, 41 1–4 35. 47 Glasoe PK & Long FA (...

Ngày tải lên: 19/02/2014, 17:20

... reaction; ND, not deter- mined. Antibodies Flag-CSN2 Flag-CSN2-Rpn6 B8 Anti-p53 + + – Anti-c-Jun + – – Anti-cullin 1 + – – Anti-cullin 3 + – – Anti-ubiquitin + – – Anti-CK2a +ND – Anti-INT6 + ND – X. ... domain of CSN2 is important for complex formation. The consequence of permanent Flag-CSN2 overexpression was de-novo assem- bly of the CSN complex c...

Ngày tải lên: 20/02/2014, 01:20

... informa- tion and opinion information. In this pa- per, we propose an Opinion PageRank model and an Opinion HITS model to fully explore the information from different re- lations among questions and answers, ... as the opinion information of sentence v i , and f(i → j|Op(v i ), Op(v j )) is the new similar- ity score between two sentences v i and v j , condi- tioned on the opinion informa...

Ngày tải lên: 20/02/2014, 07:20

... b-sheet conformation [ 1–5 ]. Another characteristic common to all amyloid aggregates is a clear green– gold birefringence upon staining with Congo red dye. The association of amyloid fibrils formation ... insights that have not only revolutionized the comprehension of the mechanisms of amyloid fibril formation but also point to novel ways for designing inhibitors. Amyl...

Ngày tải lên: 23/03/2014, 11:20