... Treatment includes a low-protein diet. Propionic acidemia (>1 in 75,000). Defect in processing four amino acids leading to ill-ness in newborns, including brain damage, coma, and death. ... brain damage, mental retardation, coma, and death. Treatment includes a diet low in protein and fat, and high in carbohydrates.Multiple carboxylase deficiency (<1 in 100,000). Defect in ... leading to buildup of lactic acid and other organic acids. Untreated, can cause brain damage, coma, and death. Symptoms, including skin rashes and hair loss, usually begin between birth and...