0.001% (ỌOOlg toxin/lOOg mo) co tac dung giam dau tren mo hinh gay dau thuc nghiem b ^ e tam nong ro ret. 0 ca 3 thoi diem : 1 gio
f l , ) ; 2 gio ( Tj); 3 gio ( Tj ) sau khi boi thuoc.
tac dung deu dat ket qua on dinh so voi truoc khi boi thuoc (To). khi boi thuoc (To).
Tai lieu tham khao
Da nghien cuu phan tach cac thanh phan co hoat tinh smh hoc trcng npc ran bang cot s^c ky hoat tinh smh hoc trcng npc ran bang cot s^c ky
voi Superdex-75, thu diroc cac che phim enzym
va toxin.
Da san xuat thu nghiem kem xoa bop ngoai da bang toxin tmh sach tach tir noc rdn hp mane bang toxin tmh sach tach tir noc rdn hp mane
Naja naja cima voi la duoc tan trcns nuoc: Kem
"Nalox".
Kem '*Natox", ngoai cac tie dung khana vi
khuin £. coli va F. aeru-^mosạ c6 cong dune
dieu tn dau day t h ^ kmh. dau viem co, dau khop kmh men. So sanh v6i kem xoa boo lam tir noc kmh men. So sanh v6i kem xoa boo lam tir noc ran tho cho thay kem xoa bop nay co cac uu diem giam dau nhanh g:ip
cima loaị
[an so voi x^m tu noc ran
1. Kumar T K. S., Lee C. S.. Yu Chiai!994V A case saidy or" cardiotoxui III Ircm Tar.van Corn: .\j:a naia jiraw
Soiulicn strucrurc and other physical Propemes. Natural toxins. V.2. p. 115. Plenum Press. Nc". ^'^r-c .NỴ 'JSẠ 2.
Clien-chung Yang; Long -sen Chang, f Í^'^^V Bicc.".emisirv and .Moiec-jiar Bioicgy :i Sr.akj r-.éjr~:.;\j-.. [ Cvc,:. Chcrr.. S:c. V.-16. .\'o 3, 319-333. 3. Cjsmnan D W ;9HCV "'iH-izyme jir.ibiccrs jnc •ir-:u" £c. .\ị 'UIT.CAC: . _jnccn: MacTiUan, 231-24T; 4. [to M. Hamako J. Sakurai Ỵ .Vlarsumoto M. Fujimura Ỵ Suzuki .\L Hasrj.Tctc K. ?:{im K. .Matsui T. (2001). Compie:e ammo acid sequence oi kaourhiaizin, a novel cobra venom me:ailcprcie:nasc •.'nin two
dismtcgnn-like sequences. 3iochemistrv:-iO:4503—i5l 1; 5. US patent^: 5.565.-3! ;l'>'6i: •Oncjr CJ;! ;nnici[>-:rs jnd
Me:hod". claims prcducrs for treatmu cancer usme Kaoircẹ .Atropor.n ir J combinaiicn: 6. 'i^ccr.\z'.z\ 0. . :)S(;\ Pracncai Hanubook on Enzvmeologỵ "' Hign shccoi", .Moscow, 2"2 p; 7. Vanden 3er;^cr. ''^".•x'cj'.c:<. Ạ J. ;'^J! ;.
.Method 01 Plant 3iochcmistrv, 4. -17-/^9; S. Turner R.. (1965). Scrceninti mc:hcds :n pnamiacoici;ỵ .i,cacemic Press.
Nc'.v York ang London, 100 - 108; 9. Hoiing Ngoc .Ann; Dang Trln Koang; Tmong Nam Haị -Ciao sat va :ach :ọ\in xis noc ran hd manu Viet .Nam (-V .Vaja). TuvCn tap bao cao !"l6i nghi khoa hoc. Vien Hoa hoc. Vicn K H i O V N , Ha Noị
7:ianizl2 nam 2C05. Tr: '9-83.
(Tiep theo trang 142)
Ve hinh thtic. hoa sy Nguyen Tnanh Dam. uy vien Thu ky Hoi dong cham Sacr. dec. r.njn ;<et:
•'Day la bo sach cong phu ciia nhieu lac gia gioi thieu hang ngan vi thuoc co kem theo hinh minh
hoa dep Cich trinh bay mach lac, khoa hoc nhu mot bo ni dien 1cm, rat tien cho viec 'ra cuu, sir
dunẹ Cone nehe an loat gop p h ^ lam cho tac p h ^ tra nen sang siia va trong irong, , co "iie .xem a hai i^ac phim^dat eiai Vane - Sach dep la su hoan thien nhimg tieu chuan d^t-p cho mot cucn sach hai i^ac phim^dat eiai Vane - Sach dep la su hoan thien nhimg tieu chuan d^t-p cho mot cucn sach
trinh bay co nghe ihuat".
Nam diu tien Hoi xuat ban Viet nam to chiic Giai da thanh conẹ Nam sau va nhieu nam tiep nua trone Neav hoi ton vuih Sach Viet Nam. tac gia dat giai se done hon. nganh Xuat ban se co them trone Neav hoi ton vuih Sach Viet Nam. tac gia dat giai se done hon. nganh Xuat ban se co them
nhieu cuon sach hay, sach dep. gop p h ^ boi duong xii tue va tam hon Viet Nam Irene ••Qiien luoc (adsbygoogle = window.adsbygoogle || []).push({});
Con N g u o f ciia Dang tạ
Hdi KHOA HOC KY THUAT PHAN TICH HOA, LY VA SINH HOC VIET NAM V I E T N A M A N A L Y T I C A L SCIENCES SOCIETY V I E T N A M A N A L Y T I C A L SCIENCES SOCIETY
' ^ ) * * . i « ^ ^
ISSiV - 0868 - 3224
Tap chi
HOA, LY VA SINH HOC
Journal of Analytical Sciences
T-11
4
2006
Tav cm v'ndr ::ch Hoạ L\ ic Sinh hue - Tav 11. So 4 2006
NGHIEN CL/U CHIET TACH VA TINH CHAT CUA TOXIN VA MOT SO NZYM THUY PHAN CO HOAT TINH SINH HOC TlJ NOC RAN HO MANG NZYM THUY PHAN CO HOAT TINH SINH HOC TlJ NOC RAN HO MANG
VIET NAM NAJA NAJA
D'C' • ' ' ! ) ( ,
T r a n Dinh Toai
'. .c" Hue nnc. V:c.': HJiccCX '\':c: Xcr:.
Tran thi Hong
r-:.-^;':r DHI-LHTX DriQC H'c Xoi
X) ' 'S JriL j^'.'L.v::' 'N .-'.XJ pnoPiZTT;!:- ' j r T O X I N .-.XO ?OML H ^ T ) K O L V = E
L'\'1'':.'.L:~ •";. '.•'. '^".11'^ X.-J\i .^-'.- \/XA SS.XiiE '\"IIX''"\i
:..;• ^:: '^•••••" " :.' " • • , . 7 : ; ••: ;'-•-'.'.'•. •>• : ( ' x : r c ; : : : ' -r'^:- •:;::•'-'•.•.<i ^ ' : r v " : ^ - ' : c ' .\ réc •.":;•':: ''C'~- :•••."•'••: T'lc c":::''"c:c~~ c :yniz:cc <uc's::ircc'~ hcic hcc:
11 ' : ' . - . .
r. r.i n:„r:e Si cue: c:^: ::ac :{: :inur:^
a :.ne r:>' ::"joc X. Cac r:e: qua trong
r. ii r. 11 IT. c." 1 c u r. r c c^ c t a c r. r 1 s n c L
::c:"u:otcx::: ncac rvtotc:::;: c-^.i
r;ẹT.á.ox:r. u6c .L '.'C^ rr.uu . _ -
Cac en::-:ne :i:r ma-/ :;-an- r.
L.'3C enz".':y-e ".r.uoc ]Cr tr.ú ::r.c;". : Phosonoiinase va Protease cue Phosonoiinase va Protease cue
nnieu non zn (adsbygoogle = window.adsbygoogle || []).push({});
— :>: r.::uor. cuoc :ieu r.Tccr. ger. quy n i t r r.Tccr. ger. quy n i t r
nor.g ịrr. '/:e: XạT.. :
" . , . - ' - - I P * • . ' - ' - - ]'2 t u
^ . u . .
naja I m U ~ ~ L C t , ' . . l i ,
.a .r: cua r.ó: rar. tn. uac trunp cnc tn. uac trunp cnc :r.: r.au r.r.iet dc: : t:er. nanr. ngr.ien
rr.ạte (Naja
• e n z y m e , t o x m j n h i m t i m h i e u n h i i n g gia t n JUoc heu cua no p h u c v u t r o n g y hoc.
e n . P H U O N G P H A P N G H I E N G i n ; 1. H o a c h a t
• N'oc r i n ho m a n g (Naja naja) dong kho (ijang a m p u i 5 g) duOc m u a cii i a n g n g h e nuoi
r a n V i n h Son. h u y e n V i n h T u d n g , t i n h V m h Phuc.
- Hoa cnat u n h k h i e t ciia h a n g Sigma: C u r a t . Gtvcme (Glvv S u p e r d e x - 7 5 . A u e n m nbonucieotide
2. T h i e : b i :
- FPLC I Float Performance L;qu:d t."i"iroinatoei*aphy).
• HPLC (Hie:h P e r f o r m a n c e Liquid C'lromaLộ-apnv - Sac ky long hieu n a n s c a o
- Quant^ pho t u n g o a i .
\\[W '.].- ".am. ' a n h . m.ay k h u ; i \ ' :ụ :]. P h u o n ' 4 p h a p n^hicMi c u u
ạ Phan tdch cdc thanh phan co hoat