Diem ndng chay dugc do tren may Smart Plus 2650
(phdng tdng hgp Heu ce 3). Phd hdng ngoai degc ghi tren may FTIR Magna 750 (NICOLET - My) tai tnjng tam Hda dau - Khoa Hca hgc - Dai hpc Khoa hpc Tu nhien. Phd khdi legng cegc do tren may 5939B - MS (Hewlett Parkard - My) tai Vien Hda hpc - Vien Khoa hoc Te nhien va Ccng nghe Qudc giạ Cac 6- aminouraxin, e-amInc-2-tiniouraxin degc tdng hgp theo
tai lieu [3, 4]. H:o chat 2,3,4,6-tetra-O-
axetylgiucopiranozyl isothioxianat degc tdng hgp theo tai lieu [5j. Hoat tinh khang khuan Va nam men degc the
nghiem tai Phdng phan tich vi sinh - Benh vien 19/8 - Bo Cong an.
Phuang phap chung tong hop cac hep chat cua 3- glucozylammo- isothiazo!o[3.4-d} pirimidin
Hdn hgp cua 0,39g tetra-O-axetyl-a-D- giucoplranczyl isothioxianat va 0,001 riol 6-aminoura:(in (hoac 5-amino-2-thlourax:nj t.'ong 10m,i xilen khan cere dun hoi lu^u each dau trong thei gian 14 g:d, sau do iam bay hai dung m.oi phan ur,g a nhiet co phong hay c cee ap suat giam. Phan can ceec loc va k=t tinh lai trong dung mdi toluen.
I V . K ^ T L U A N
• Da tdng hep ceec 5 N-glucozit la cac hgp chat 3- de kien phd hong ngoai va phd knci !eer;C.
(tetra-C-axer.I-a-D-gluccpiranozylaminojisothiazolo [3.4- • Da t.he hoat tinh khang khuan va knang nam cla d]pinmicin^.c-:ion khac nhau bing phan eng cua cac cac hep chat ca tdng hep ceec.
amincuraxin, aminothicuraxin vci glucozyl isothioxianat. Cong trinh d'jcc hoan thanh va se ho trg cua T.-^r.c Cau true cla cac N-glucczit nay degc xac nhan bang cac tam. Ho trg nghien cuv chau A Bai l~.cc Oucc gia Ha tizi
TAI Lieu THAM KHAO
1. Zcig^iev/ J. V/':zzak, Monosaccharide Adv.
Carbohydr. Cnem. B.zchem., Vcị 44 (1984), pp.
91 -145.
2. Hasiạ-n Ẹ, The m.ass spectra of som^e aryl
glucosides, Carbohydr. Res., 5 (1367), pp. 161-165.
3. CJ. Snishoo, M.B. Devani, K.S. Jain, Reation of
nitrines uncer acidic ccr.ditions: Pari VI - Synthesis of 6-amino-1,3-ciar/l-2-thicuracils under acidic condition, Indian J. Chem., Vol. 293 (1990), pp. 674 - 675.
4. CJ. Snisncc, K. 3, Jan SR Jạn, Rei
nitriies acidic czr:dii:cns: Fart / / -
amJnÓ1'ary!uraci!S. 6-am:inc-1-aryi-2-tn:curacils azz 5- ammÓl,3'diar/:-2'thicuraciis unzê azid:z ccr.cz.zr, Indian J. Cnemị, Vol. 35B (1995), pp. 652 -655.
5. T, Hassei, H.P. Mul;ê Process for :ze
preparation of acýated suga-s \v.:z a glyzosioiza iy bended isotniQcyanate group, US Patent 4622^71
(1936), A SO 9 SO 9
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