L INTRODUCTION
KET QUA NGHIEN ClTU KHOA HOC
Ten De tai:
TONG HOP V A CHUYEN HOA M Q T SO DAN XUAT CUA OrD-GLUCOZO VA a-D-GLUCOZAMIN OrD-GLUCOZO VA a-D-GLUCOZAMIN
Mas6: QT-05-16
Cor quan chu tri de tai: Truang Dai hgc Khoa hoc Tu nhien, DHQG Ha Noi
Dja chi: 334 Nguyln Trai, Quan Dong Da, Ha Noi Dien thoai: (4) 858 4529; Fax: 858 5277
C<r quan quan ly de tai: Dai hgc Qu6c gia Ha Noi
Dia chi: 144 Duong Xuan Thuy, Ciu Giiy, Ha Noi, Viet Nam Dien thoai: (4)7682587
Tong kinh phi thu-c chi: 15.000.000 đng.
Trong do: - Tu ngan sach nha nuoc: 0 trieu dong - Tu kinh phi cua trudng: 5 trieu dong - Vay tin dung: 0 trieu dong - Von tu co: 0 trieu dong
- Thu hoi: 0 trieu dong
Thai gian nghien cun: 12 thang
Thoi gian bat dau: thang 1 nam 2005 Thoi gian ket thuc: thang 12 nam 2005
Ten cac can bo phoi hop nghien cihi:
- PGS.TS. Nguyen Dinh Thanh, Chu tri de tdi
- Pham Hong Lan
- Mot so sinh vien phong THHC-l
So dang ky De tai
Ngay / /2005
So chung nhan dang ky ket qua nghien cihi
Ngay / /2005
Tinh trang bao mat
> Pho bien rong rdi [X] > Pho bien han che > Bdo mat
Tom tat ket qua nghien ciru:
1. Da tdng hgp dugc 5 hgp chit 2-axetamido-2-deoxi-p-D-glucopiranozylamm tu
N-axetyl-p-D-glucozamin va mot s& 2-aininobenzo-l,3-thia2oI hay 2-amino-l,3-thiazol
th^ khac nhaụ
2. Da tong hgp dugc 6 hgp chit 4,6-etyliden-P-D-glucopiranozyIamin tir 4,6- etyliden-P-D-glucopiranoza va mot so 2-aminobenzo-l,3-thiazol hay 2-amino-1,3-thiazol th§ khac nhaụ
3. Da t6ng hgp dugc 8 hgp chit 3-(tetra-(9-axetyl-a-D-glucopu-anozylamino)- isothiazolo[3,4-d]pirimidin-4,6-dion khac nhau tu cac aminouraxin, aminothiouraxin voi glucozyl isothioxianat.
4. Da nghien cuu be mat nang lugng quay doi vai nhom hidroximetyl n cua a-D-2-amino-2-deoxyglucopyranoza va P-D-2-amino-2-deoxygluco-pyr
dugc mo ta bang each su dung phuang phap ab initio a cac muc li thuylt cao 6-
6-31G(2d,lp), va nhan thiy ring su chuyin d6i qua lai de dang nhit trong pha km m ^.uc* cac cau dang TG va GT (trong ca hai truong hgp anome a va P).
5. Da nghien cuu anh huang cau hinh cua nhom 2-axetamit din ciu dang bin cua phan tu N-axetyl-D-glucozamin bang phuang phap toi uu hoa hinh hgc theo phuang phap ca hoc phan tu AMBER va theo phuang phap co hgc lugng tu AMI, va da nhan thiy ring a phan tu N-axetyl-D-glucozamin, anome P ben hon anome a ve mat nang lugng (khi khong CO anh huong cua dung moi) va doi voi cac anome thi cau hinh bin nhit la ciu hinh (E)-syn.
6. Cau true ciia cac hgp chat da tong hgp dugc xac nhan bang cac phuang phap vat ly hien dai (pho hong ngoai, pho cong huong tu hat nhan proton va cacbon-13 va ph6 kh6i lirgng).
7. Da thu hoat tinh khang khuan va khang nam cua mot s5 hgp chat da tong hgp duac.
I
Kien nghj ve quy mo va doi tugng ap dung ket qua nghien cuu:
• Viec gan ket phan tu monosaccarit co the lam tang kha nang kha nang phan ung ciing nhu tac dung sinh hgc cua cac dan xuat nhan dugc, van de nay can dugc nghien cuu them.
• Cac ket qua nghien cuu dong gop vao linh vuc hoa hgc cacbohidrat.
Chirc vu Chu nhiem
Ditai
Thu truong Co* quan chu tri de
tai
Chu tich Hoi dong danh gia
chfnh thuc
Thu truong Co quan quan
ly De tai
Ho va ten Nguyen Dinh
Thanh Trdn Nghi KiLjih Ikôi I hdi
Hoc ham,
Hoc vi
Pho Giao su,
Tien sy GS. Tien sy