I- DAT VAN DE
TONG HOP, NGHIEN CLFU CAU TAO VA HOAT TINH SINH HOC COA MOT SO BIS-AZOMETIN CHQA DI VONG PIRIDIN
COA MOT SO BIS-AZOMETIN CHQA DI VONG PIRIDIN
1 ^ Den Toa •<oan 6-6-2<H'}9
TRAN THACH VAN, TRAN THI THANH VAN. LE TH| THANH T R A
Khoa Hda hoc. Truang Dai hoc Khoa hoc Tu nhien. Dai hoc Qudc gia Hd Ndi
ABSTRACT
Some derivatives of bis-azomethine containing pyridine heterocvclic were synthesized hy condensation of aldehyde with diamines. The products were recrystallization in ethanol. methanol ...Thev are white, yellow, and brown crystals. Theirs structure were identified by íV. IR. MS. H- NMR spectroscopies. The biological activity of the synthesized compounds uas tested
1 - DAT VAN DE
Trong nhirng nam gan day, hpp chat ometin va bis-azometin da duoc img dung mg nhieu ITnh vuc khac nhau nhu diing lam
u gia luu hoa cao su, tao phirc vdi cac ion n loai va dac biet nhieu azometin co kha nang
ch^ an mdn kim loai rat cao, cao hon ca cac dehit va amin tuong irng. Ngoai rạ cac ometin cung co nhirng boat tinh sinh hpc d.-inu u y nhu hoat tinh khang khuan, chong viem. ua benh thuong ban... Cd rat nhieu cac cong fih nghien ciru d Viet nam va the gidi da cong ve azometin [ 1 - 3 ] nhung nhirng nghien ciru bis-azometin van con ban chẹ De dong gop 0 ITnh vuc nghien ciru ve azometin, trong ng trinh trudc day [6] chiing toi da cong bo irng ket qua ve tdng hop mot so azometin va ;-azometin chira di vong piridin vdi muc dich sir dung chung de nghien ciru cac tinh chat u kha nang ire che an mon kim loai va hoat h sinh hpc ciia chiing trong giai doan tiep fọ Trong cong trinh nay chiing toi tiep tuc ng bo nhung ket qua long hop va nghien ciru J lao mpt s6 bis-azometin khac chira vong
idin va ket qua tham do hoat tinh sinh hpc a nhung bis-azometin da cong bo trudc day
cung nhu boat tinh sinh hpc cua nhung his- azomclin cong bd trong cong trinh naỵ
Trong cong trinh na\ chiing toi da long hop 14 bis-azometin chira di \6ng piridin tu phan irng giira andehit \a diamin thom theo so đ phan irng sau:
2 Ar'-CHO NH.-Ar--NH.
Ar'-CH-N-Ar^'-N-CH Ar' + 2H:0
Trong đ: Ar': vong benzen. benzen thẹ di vdng thom.
thorn...
Ar^ vdng benzen. di \6ng
I I - T H U C NGHIEM
Diem chay ciia cac san pham dupe do tren may STUART SMP3.
Pho hong ngoai dupe do tren ma> MAGNAIR 560 Spectrometer.
Phd tu ngoai dupe do tren ma\ UV-24^0 SHIMADZU ciia hang SIMAZỤ
Pho khoi lupng duoc do tren ma\ Ll-MS. Pho cong hudng lii" do tren ma> BRUCKER 500 MHz.
Cac azometin duoc dieu che bang cach dun soi hoi luu hon hpp andehit va amin theo U 1?