I- DAT VAN DE
3NG HOP, NGHIEN CLfU CAU TAO VA HOAT TINH SINH HOC
CUA MOT SO AZOMEnN C H U A Dl VONG PIRIDIN
Den Tda scan 6-6-2009
VN THACH VAN, TRAN THI THANH VAN, LE THI THANH TRA, CAO THI HUONG. CHU THI LANH
Khoa Hda hoc, Trudmg Dai hoc Khoa hoc Tu nhien. Dai hoc Quoc gia Hd Noi
ABSTRACT
Some derivatives of azomethine containing pyridine heterocyclics were synthesized by ndensation of aldehyde with aminẹ The products were recrystallization in ethanol. methanol They are yellow or white crystals. Theirs structure were identified by IR. UV, MS. H-NMR ictroscopies. The biological activity of the synthesized compounds was tested.
I - DAT VAN DE
rong nhung nam gan day, hpp chat ;tin da duoc irng dung trong nhieu ITnh liac nhau nhu diing lam phu gia luu hoa 1, tao phirc vdi cac ion kim loai va dac biet azometin co kha nang ire che an mon kim at cao, cao hon ca cac andehit va amin irng. Ngoai ra, cac azometin cung co ; hoat tinh sinh hpc dang chii y nhu boat khang khuan, chong viem, chira benh ghan... De dong gop vao ITnh vuc nghien e azometin, trong cong trinh trudc day [6] ;t6i da cong bo nhirng ket qua ve tong hpp 6 azometin va bis-azometin chira di vong 1 vai muc dich se sir dung chiing de n ciru cac tinh chat nhu kha nang ire che on kim loai va hoat tinh sinh hpc ciia ; trong giai doan tiep theọ Trong cong nay chiing toi tiep tuc cong bo nhirng ket ong hap va nghien ciru cau tao mpt so -tin khac chira vong piridin va ket qua do hoat tinh sinh hpc ciia nhung azometin Ig bo truoc day cung nhu hoat tinh sinh ua nhirng azometin cong bo trong cong laỵ
Trong cong trinh nay chiing toi da tong hap 20 azometin chua di vong piridin bang phan ung giira andehit va amin thom theo so do phan img sau:
Ar'-CHO + Ar^-NH2
Ar'-CH=N-Ar^ + H2O Trong da: Ar': vong piridin thẹ..
Ar : he vong benzen, di vong thom... II - THUC NGHIEM
Diem chay ciia cac san pham duoc do tren may STUART SMP3.
Pho hong ngoai duoc do tren may MAGNAIR 560 Spectrometer.
Pho tir ngoai dupe do tren may UV-2450 Shimadzu ciia hang SIMAZỤ
Pho khoi lupng dupe do tren may El-MS.
Pho cong huong tir do tren mav BRUCKER
500 MHz.
Cac azometin dupe dieu che bang each dun soi hdi luu hon hop andehit va amin theo ti le moi phii hpp Irong khoang 16 gia, cac dung inoi sir dung la etanol, metanol.... San pham dupe ket tinh lai nhieu lan trong etanol hoac benzen. 269