zinc apoptosis and cancer

... the androgen receptor to control cellular processes such as proliferation, apoptosis and other metabolic events in prostate cancer [14] Taken together, a combination of gene amplification and androgen ... Western countries and is the leading cancer death, next to lung and colorectal cancer In the present study, we demonstrate the physiological consequences of TPD52 expression in the androgen responsive ... (2004) Overexpression, amplification, and androgen regulation of TPD52 in prostate cancer Cancer Res 64, 3814–3822 Wang R, Xu J, Saramaki O, Visakorpi T, Sutherland WM, Zhou J, Sen B, Lim SD, Mabjeesh...

Ngày tải lên: 30/03/2014, 02:20

... of microtubules (red) and centrosomes, and merged images of microtubules, centrosomes and DNA (blue) in metaphase HeLa cells HeLa cells were treated with and 10 lM benomyl and compared with those ... Shown are, control after 40 h (lane 1); 20 h after and 20 lM of benomyl treatment (lanes and 3); and 40 h after and 20 lM of benomyl treatment (lanes and 5) suppressed the reassembly of cold depolymerized ... benomyl and incubated on ice for 10 and subsequently fixed and processed for immunofluorescence microscopy using antibodies raised against tubulin, and DAPI, to stain kinetochore microtubules and DNA,...

Ngày tải lên: 30/03/2014, 10:20

... Apoptosis, Senescence, and Cancer Cancer Drug Discovery and Development Beverly A Teicher, Series Editor Apoptosis, Senescence, and Cancer, edited by David A Gewirtz, Shawn E Holt and Steven ... Kelland and Nicholas P Farrell, 2000 Apoptosis and Cancer Chemotherapy, edited by John A Hickman and Caroline Dive, 1999 Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and ... phagocytes (2) From: Cancer Drug Discovery and Development Apoptosis, Senescence, and Cancer Edited by: D A Gewirtz, S E Holt and S Grant © Humana Press Inc., Totowa, NJ Part I / Apoptosis and Alternative...

Ngày tải lên: 29/06/2014, 06:20

... contributions YZ and AY are researchers working in cancer biology and carried the study QL and YB undertook the Statistical analysis QZ along with MZ designed the work and interpreted the results QZ and MZ ... trioxide is an effective anticancer agent with potential for human gastric cancer Arsenic trioxide can reduce proliferation and induce apoptosis in SGC7901 human gastric cancer cells There are two ... western blot and stained by both anti-Bcl-2 (BH3) and anti-Bax (6A7) antibodies, express conformational change of Bcl-2, which may play a role in arsenic trioxide-induced apoptosis and Bax activation...

Ngày tải lên: 09/08/2014, 03:21

... tables and figures and has been involved in type of packaging likewise in the submission process PCL has been involved in conception and design of the study and in drafting the manuscript and has ... are 1) non-homologous end joining (NHEJ) and homologous recombination repair (HRR) [29,30], and 2) cell-cycle checkpoints that provide time for repair and apoptosis [31] Depending on the severity ... spontaneous apoptosis) ; and the coefficient b defining the slope of the curve a and b followed a normal distribution (Kolmogorov-Smirnov test, p > 0.05) Mean of b was 7.93 ± 2.68 standard deviation...

Ngày tải lên: 09/08/2014, 09:20

... eagle medium (Gibco, Grand Island, NY) containing 10% (v/v) heat-inactivated fetal bovine serum (Gibco, Grand Island, NY), penicillin (100 U/mL) and streptomycin (100 mg/mL), and they were maintained ... the expression of b1- and b2-ARs was determined at both the mRNA and protein level in SGC-7901 and BGC-823 cells by RT-PCR and western blot Our results showed that b1- and b2-adrenergic receptors ... the data and plotting of the figures were performed with the aid of software (Origin Version 7.5 and SPSS Version 13.0) Results Expression of b1- and b2-adrenergic receptors in SGC7901 and BGC-823...

Ngày tải lên: 09/08/2014, 09:20

... cancer cells through induction of apoptosis and sub-G1 arrest in a concentration- and time-dependent manners SAHAresistant cancer cells express high levels of cyclin A, Ki67, p53, survivin, and ... concentrations Specifically, SAHA induced apoptosis and sub-G1 arrest in 320 HSR colon cancer cells by inhibiting the protein expression of anti -apoptosis proteins, survivin and Bcl-xL Multiple mechanisms ... been studied in a thyroid cancer cell line [6], human lymphoma cells [18], breast cancer [19] and non-small cell lung carcinoma [20], as well as endometrial and ovarian cancer cells [21,22] These...

Ngày tải lên: 10/08/2014, 05:21

... 1,25-(OH)2D3 and EB1089 on cell cycle kinetics and apoptosis in MCF-7 cells Breast Cancer Res Treat , 1997; 42: 31–41 29 Jiang F, Bao J, Li P, et al Induction of ovarian cancer cell apoptosis by ... metabolites were previously found to induce apoptosis of embryonic renal cells (26), breast cancer cells (27, 28), ovarian cancer cells (29), and prostate cancer cells (30) In contrast, some studies ... Bax/Bcl-2 ratio and finally limiting glomerular cell apoptosis Our study demonstrates the protective effect of 1,25-(OH)2D3 on podocyte apoptosis by down-regulating Fas, FADD and Bax and up-regulating...

Ngày tải lên: 25/10/2012, 11:40

... are 0.33, 0.36, 0.46 and 0.4 nm for carcinoma, fibrocystic changes, adipose and fibroglandular tissues respectively Comparison of the measured signatures between the fresh and frozen tissues is ... materials and body tissues Med Phys 1987; 14 (4): 1811-1816 Lewis RA, Rogers KD, Hall CJ, Towns-Andrews E, Slawson S, Evan A, Pinder SE, Ellis IO, Boggis CRM, Hufton AP and Dance DR Breast cancer ... between normal and tumor breast tissues Furthermore, it is possible to differentiate between fibrocystic changes and carcinoma using this parameter The difference between adipose and tumors is...

Ngày tải lên: 02/11/2012, 11:08

... frequent types of cancer diagnosed in the United States in decreasing incidence are breast cancer, prostate cancer, lung cancer and colon cancer; yet lung cancer is the deadliest form of cancer in the ... Cdc28 and classes of vertebrate cyclins (D- and E-type cyclins in G1 and A -and B-type cyclins in G2/M) that control a family of Cdks (cyclindependent kinases) greatly enhanced our understanding ... 1997; Zachariae and Nasmyth 1999) These studies and others demonstrated the universality of the cell Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 231 cycle, and strongly suggested...

Ngày tải lên: 25/10/2013, 21:20

... cancers, gastrointestinal and other associated cancers, lung and upper aerodigestive cancers and prostate and urologic cancers, each have biomarkers in prevalidation and validation phases in which ... Texas M D Anderson Cancer Center Colorectal and Other Gastrointestinal Cancers 35 Colorectal Cancer Colon cancer is the third most frequently diagnosed cancer in the United States and the third ... sequences and other biomarkers have been identified as promising biomarkers for bladder and prostate cancers; and mutations and deletions in mitochondrial DNA were detected in prostate and other cancers...

Ngày tải lên: 14/02/2014, 21:20

... bioassays and are carcinogenic (Gold et al., 1997b) Dehydroepiandrosterone (DHEA) and DHEA sulfate are the major secretion products of adrenal glands in humans and are precursors of androgenic and ... Stofberg and Grundschober (1987) 800 Stofberg and Grundschober (1987), Lorenz and Maga (1972) Stofberg and Grundschober (1987), Arkima (1968) (7300) TAS (1989), Nelson and Hoff (1969), Kazeniac and ... Stofberg and Grundschober (1987), Blauch and Tarka (1983), Nagata and Sakai (1985), IARC (1991) EPA (1989a), Risch and Herrmann (1988) TAS (1989), Eltayeb and Roddick (1984) 4100 Stofberg and Grundschober...

Ngày tải lên: 14/02/2014, 22:20

... with cancer of the mouth, larynx, pharynx and esophagus, and heavy beer drinking is associated with cancer of the rectum Cancer can develop anywhere along the gastrointestinal tract, but colon cancer ... Nutrition and Health, stomach cancer has been found among populations who eat lots of pickled vegetables (Japan), salted fish (Norway) and smoked trout and mutton (Ireland) Esophageal cancer is ... certain types of cancer, especially if you drink and smoke Choose high-fiber foods Besides fresh fruits and vegetables, add more whole grain breads and cereals and legumes (dried peas and beans) to...

Ngày tải lên: 15/02/2014, 04:20

... mortality and YLL, and the transition towards cancer In more recent years, the highest burdens of disease came from cancers in men and from cardiovascular diseases in women Keywords Cancer, Cardiovascular ... rates and numbers of deaths were performed for all ages and by age groups (0–14, 15–34, 35–54, 55–74 and ≥75 years) The YLL due to premature mortality for each cause (CVD and cancer) , gender and ... 1980 and 2010, the burden of CVD was much higher compared to cancer and, in 2010, CVD were responsible for 10,000 deaths more than cancers Among men, the YLL from cancer increased between 1980 and...

Ngày tải lên: 15/02/2014, 04:20

... (noncancerous) or malignant (cancerous) Vertebra: The bony segments that make up the spinal column The mission of The Bone and Cancer Foundation is to: • Provide information to cancer patients and ... information can be found in the Bone and Cancer Foundation publication “Osteonecrosis of the Jaw – Information for Cancer Patients” available online at www.boneandcancerfoundation.org or by calling ... percent of people with lung cancer will have their cancer spread, or metastasize, to bone When lung cancer metastasizes, tumor cells from the original cancer break off and travel through the blood...

Ngày tải lên: 15/02/2014, 05:20

... for skin cancer, colon cancer, and lung cancer is the same for women and men (trans or not) Trans people should have the same screening as anyone else for these kinds of cancers Some cancer protocols ... detection and treatment of cancer The rest of this booklet focuses on trans-specific protocols for cancer screening Trans-Specific Cancer Screening Recommendations The earlier cancer is detected and ... spread Cancer of the uterus” usually refers to cancer of the lining of the uterus (endometrium) Endometrial cancer is the fourth most common type of cancer in BC and is the most common cancer...

Ngày tải lên: 15/02/2014, 05:20

... to ERBB3 and ERBB4 NRG1 and NRG2 bind to both ERBB3 and ERBB4, whereas NRG3 and NRG4 only bind to ERBB4 [3] Although these ligands show redundancy, heparinbinding-EGF is the only ligand whose ... 3-kinase, and thus is a preferred dimerization partner EGFR and cancer EGFR overexpression and cancer EGFR is expressed in a variety of human tumors, including those in the lung, head and neck, ... AKT and the signal transducer and activator of transcription (STAT)3 and STAT5 pathways (Fig 2) [3] These eventually result in cell proliferation, migration and metastasis, evasion from apoptosis, ...

Ngày tải lên: 16/02/2014, 09:20

... because of their low concentration and high hydrophobicity New tools and strategies are needed so that membrane fractions from cancer cells can be screened for candidate biomarkers In this study, ... Overexpression of CLDN3, HLA-A1, TAPBP and SLC25A4 in colorectal cancer has not been prominently reported, and there is interest in developing these proteins as diagnostic and prognostic markers for this ... in epithelial and endothelial cells [22] Specifically, CLDN1, -3, -4, -5, -7, -10 and -16 have been found to be altered in various cancers [23] Overexpression of these proteins in cancer is unexpected,...

Ngày tải lên: 16/02/2014, 15:20

... (2003) Calcium and apoptosis: facts and hypotheses Oncogene 22, 8619–8627 Monteith GR, McAndrew D, Faddy HM & RobertsThomson SJ (2007) Calcium and cancer: targeting Ca2+ transport Nat Rev Cancer 7, ... in apoptosis and invasion J.-M Gu et al is a distinguishing characteristic of epithelial and many other types of cancers, where decreases in TJ expression are associated with cancer stage and ... occludin (OccWT) and variant occludin in apoptosis and invasion, as determined by assay, we revealed that exon played a major role in the induction of mitochondria-mediated apoptosis and the reduction...

Ngày tải lên: 18/02/2014, 18:20

... groups and demonstrated the important differences between VTE in adults and pediatric patients and called for evidencebased guidelines for management and prevention of VTE in neonates and children ... patient lives” and issued a call for action stating that DVT and PE constitute major health problem in the USA and more people die of PE than motor vehicle accidents, breast cancer or AIDS, and physicians, ... Pselectin and thrombospondin all of which help promote thrombosis (Jy, et al 2007) 3.1.3 Microparticles, VTE and cancer In contrast to the above discussion for idiopathic VTE – thrombosis, cancer and...

Ngày tải lên: 19/02/2014, 23:20