women apos s movement in north america

... pravastatin [59]; immunosuppressants such as cyclo‐ sporine [60]; anti-virals such as saquinavir [61]; a phosphodiesterases-5 inhibitor such as sildenafil [62]; antihistamines, including as terfenadine ... could interact with P-gp substrates such as digoxin, fexofenadine, indinavir, vincristine, colchicine, topotecan, and paclitaxel in the small intestine For this reason, this fruit should be consumed ... bifacient in traditional medicine; it is also used in the treatment of some diseases such as scarlatina, putrid sore throat, hoarseness, dispepsia, yellow fever, piles and snakebite [152] Capsaicin...

Ngày tải lên: 29/03/2014, 21:20

... computers could in principle handle some of the toughest computing problems, such as factoring numbers to break encrypted messages— answering those questions in seconds instead of the centuries that ... that incorporates the brain of the sea lamprey Petromyzon marinus to scientists in Somerset, England In fact, Ferdinando Mussa-Ivaldi of Northwestern University leads the research team In “Seeds ... combustion gases; the engines failed in succession, leading to the subsequent crash When the flagship SST is fully retrofitted, it should be able to resist damage from tire blowouts, mishaps that...

Ngày tải lên: 12/05/2014, 16:09

... classes of compounds is discussed in the following sections Fig also includes the overall results for three QM methods (PM3, HF/6-31G* and B3LYP/6-31G*) These results will be discussed in Sec ... charges in the various force elds are assigned in dierent ways For instance, the basic OPLS* charge set is based on liquid-phase simulations in explicit solvents, but more recent versions also employ ... INTERMOLECULAR INTERACTIONS Calculations of intermolecular interactions are extremely important in many aspects of modern medicinal chemistry Docking of ligands into cavities in targets is used in structure-based...

Ngày tải lên: 12/05/2014, 17:28

... DFS was selected, was then generated by combining the ring systems described above, with a set of desirable side-chains (Fig 2c, d) These included a set of side-chains found in existing drugs, ... by substituting the side-chains onto the ring systems Each ring carbon atom was substituted with side-chains found in known drugs and by the lipophilic side chains, whilst ring nitrogens were substituted ... against isolated enzymes or proteins in functional assays; this has become standard practice in HTS In principle it should be possible to this with fragments, but several pitfalls can arise: solubility...

Ngày tải lên: 29/05/2014, 23:54

... use of brine shrimps, ants and insects like Drosophila sp., cell lines in different media, tissue culturing, ligand bindings, use of rabbits and rats Assays may identify promising molecular structures ... Cephalosporin, Gentamycins Flavonoids Flavonoids, Saponins Quinines, Pamaquines, Phenacetin Alkaloids, Flavonoids Flavonoids Lignans, Saponins Nesogordonia papaverifera, Centrosema pubescens, Parinari ... kashaya (astringent) Tastes provide varying degrees of nourishing strength Sweet taste is the most nourishing, and as each taste becomes less nourishing, it becomes more bitter, until it is astringent...

Ngày tải lên: 27/06/2014, 10:20

... number of infectious diseases with some success, including the escalating challenge of methicillin-resistant S aureus (MRSA) (see Pepper, 2008 and references therein) S aureus produces numerous virulence ... of scientists and non-scientists overseeing the clinical research) Phase studies commonly use human volunteers to determine human safety and pharmacokinetics Frequently, these studies also include ... medicines These sub parts of drug discovery process can be addressed by undertaking invitro toxicology studies and pharmacokinetic studies to understand drug interactions In one of the studies we...

Ngày tải lên: 27/06/2014, 17:20

... Trypanosomiasis (sleeping sickness, Chagas disease) T brucei (sleeping sickness) T cruzi (Chagas disease) HAT: 300,000 cases annually Chagas: 16 million existing infections Schistosomiasis Schistosoma ... neurocysticercosis, scabies and infectious parasitic diseases including diseases such as Malaria, Dengue fever, Kalaazar, Toxoplosmosis Table describes some of the neglected diseases and their respective ... binding site Access to data analysis and visualization software is required at this point Step 5: Rescoring: Best scoring compounds are rescored by using sophisticated scoring functions Step Selection:...

Ngày tải lên: 02/07/2014, 13:13

... Kumar S, Tsai CJ, Nussinov R: Folding funnels and binding mechanisms Protein Eng 1999, 12:713-720 Ma B, Shatsky M, Wolfson HJ, Nussinov R: Multiple diverse ligands binding at a single protein site: ... comment reviews Factor reports -1 -3 -2 -1 deposited research -2 Factor Discussion Since ligand-protein binding is one of the most basic biochemical processes, the present findings have broad ... tracing the chronology of ligand binding to proteins The most challenging issue in life sciences may be elucidating how organisms originated from inorganic scratches (gases, water and clays),...

Ngày tải lên: 14/08/2014, 08:20

... impressive was McKim s use of in vitro cell-based toxicity screens early in the drug discovery process to predict toxicity in vivo Roger Ulrich (Rosetta Inpharmatics, Seattle, USA) is applying ... compounds in treating cancer Samir Hanash (Fred Hutchinson Cancer Center, Seattle, USA) and colleagues are applying a host of proteomic tools to samples from human patients with the aim of establishing ... establishing tissue- and serum-based markers for both diagnostics and functional classification of disease He described the capture of cell-surface proteins via biotinylation to examine differences in expression...

Ngày tải lên: 14/08/2014, 14:21

... widespread cross-hybridization Szallasi cites several causes for the observed inconsistencies, including the use of incorrect probes, poor understanding of the sequence dependence of ⌬G (Gibbs free ... (Harvard s Children s Hospital, Boston, USA) pointed out the implications of using a single hybridization protocol for the thousands of distinct probes that comprise a microarray, resulting in widespread ... platforms?” he asked Marc Salit (NIST) sees NIST s role in this area as developing the tools needed to understand the performance of geneexpression microarrays Such tools are likely to include standards,...

Ngày tải lên: 14/08/2014, 14:22

Ngày tải lên: 14/11/2014, 06:18

Ngày tải lên: 14/11/2014, 09:52

... it was expensive and some parasites became increasingly resistant to it The supply of the drug – it was imported from Java – was also inconsistent during periods of global unrest By the 193 0s, ... showed Paludrine caused a slight reduction in blood glucose levels Flu in the Philippines At the same time in the Philippines, molecules in that same biguanide class were being used by Eusebio Garcia, ... eminent specialist in infectious diseases He was treating patients suffering from influenza, as well as endemic malaria He is vague as to how, in 1949, he got hold of what he termed ‘a new synthetic’...

Ngày tải lên: 12/07/2015, 15:49

... corresponding observed descriptor This matrix of synthetic vectors is labelled internally as Class Subsequently, the Random Forest classifier uses Class and Class as training sets in a supervised ... unlabeled input items and their corresponding descriptors One form of unsupervised learning is clustering It is the assignment of a set of input items into subsets (clusters) so that items in the same ... Forest Clustering, Decision Stump versus µ+3σ Method using 14 descriptors 31 2.3.2 Performance of Random Forest Clustering using Hopkins-based selected descriptors versus 14 descriptors...

Ngày tải lên: 08/09/2015, 22:12

... Activating Factor Phosphate Buffered Saline Principal Component Analysis Protein Kinase C Phospholipids Partial Least-Squares Partial Least Squares projection of latent structuresDiscriminant Analysis ... revival of interest in the traditional screening of drugs from plants has been observed following success stories of discovery of blockbuster drugs from natural sources Examples are such as paclitaxel ... Preliminary data processing 102 4.3.9 Data processing 103 viii 4.4 4.5 4.3.9.1 Analysis using Mass Profiler Professional 103 4.3.9.2 Analysis using OPLS, PLS-DA, Chi-squared...

Ngày tải lên: 10/09/2015, 08:25

... one host within lifestages Malaria and single celled protozoa Parasite Up to 1mm Some parsites can cause diseases by toxins, others directly cause diseases Parasitic infection can be caused by ... technologies to complement HTS assay and synthesis Virtual screening (VS) is a computational technique used in drug discovery research It involves rapid in silico assessment of large libraries of chemical ... targets are demanded to be investigated to treat new disease or overcome drug resistances problems Some drug candidates may lose efficacy or cause safety issues such as severe side effects during...

Ngày tải lên: 10/09/2015, 09:04

... databases, the data access modes of these database are not specifically designed for optimally supporting such tasks There is a need to introduce new access modes based on such widely-used disease ... classification systems for more refined classification of disease subclasses and patient subpopulations responsive to a particular treatment so as to better facilitate the diagnosis, prescription, monitoring ... agents of similar targets) Ligand based machine learning methods such as combinatorial support vector machines (Combi-SVM) have recently been explored as VS tools for searching dual kinase inhibitors...

Ngày tải lên: 12/09/2015, 09:10

... Drug Resistant xix Chapter Introduction 1.1 Infectious diseases Infectious diseases are caused by pathogenic microorganisms, such as bacteria, viruses, parasites or fungi; the diseases can spread ... in Table They are classified by chemical class such as arylaminoalcohol, 4-aminoquinolines, 8amionquinolines, sesquiterpene lactone (artemisinin), biguanides, diaminopyrimidines, sulfonamides, ... chest pains, weakness, weight loss, fever and night sweats Treatment for active, drug-sensitive TB consists of medicines known as first-line drugs and is administered for a period of months [a...

Ngày tải lên: 22/09/2015, 15:17

... electrophoresis was carried out in a Hoefer system and the protein bands were visualized using the Silver Quest silver staining kit 4) Densitometry The silver stained gel was scanned using GS-800 calibrated ... in fibroblast culture may be a valuable tool in tissue engineering The presence of collagen fibrils in tissue constructs is essential in maintaining the mechanical strength and defining the shape ... covalent cross-links within and between the collagen molecules These cross-links, that are formed from specific lysine and hydroxylysine residues, are essential in providing the tensile strength...

Ngày tải lên: 09/10/2015, 11:07