whole body skeletal muscle transduction in neonatal dogs with aav 9

... 7.5 4 59 935 4.45 14.6 16 .9 0. 69 185 106.6 33.2 71.3 39. 2 22 .9 43.6 12.4 31.0 9. 6 701 1750 6.66 24.2 29. 9 1.01 162 70 .9 27.0 41.7 29. 2 15 .9 40.6 11.1 18.1 6 .9 638 1581 5.06 14.8 16.7 0 .90 1 49 52.3 ... regression in 98 non-institutionalized 75-year-old subjects R TBSMM50 kHz TBSMMBW TBSMMnoBW R2 SEE (kg) SSE PRESS R2 pred 0 .96 0 .96 0 .96 0 .93 0 .93 0 .92 1. 59 1.60 1.64 231.4 235.6 2 49. 6 265 .9 270.5 ... 11 .9 30 .9 6.1 13.2 5.5 532 1122 4.22 11.5 11.8 0.71 173 97 .5 36.3 55.5 45.7 21.0 50.2 16 .9 23 .9 8.3 766 2073 6. 39 19. 5 23.6 1.08 175 82.0 26.6 57.7 24.3 18.7 29. 6 7 .9 27.2 8.8 5 39 1261 5. 49 20.0...

Ngày tải lên: 28/03/2014, 20:20

... factors in skeletal muscle (e.g., anti-oxidant therapy or strength training paradigms) may prove most beneficial to maintain skeletal muscle mass The IL-6 family of cytokines, including IL-6, ... associated with downstream induction of atrogin-1 expression in in vitro models of muscle atrophy [33] Atrogin-1, an E3 ubiquitin ligase, is increased in alcoholic muscle [16,27,47] or muscle from ... in PBS, and then incubated in an avidin-rich solution for 60 After a final wash, positive biotin-avidin binding was observed with diaminobenzidine All sections were visualized with a Leica microscope...

Ngày tải lên: 10/08/2014, 05:22

... problems Mean (±SD) finishing time of the 14 athletes in the amino acid group was 624.3 ( 79. 5) min., whereas the remaining 13 athletes out of the control group finished in 697 .8 ( 89. 7) The mean difference ... L-Isoleucine 62.5 L-Valine 62.5 L-Arginine 62.5 L-Choline 31.25 2.5 L-Cysteine 50 L-Tyrosine L-Lysine 50 31.25 2.5 L-Phenylalanine 31.25 2.5 data were obtained using a skin-fold caliper (GPMHautfaltenmessgerät, ... Upon arrival at the finish, the same measurements were performed within one hour after finishing, there being 27 finishers Questionnaires of subjective feelings In combination with the pre- and...

Ngày tải lên: 11/08/2014, 23:21

... (17 .9) 24.3 (5.2) 70.5 (15.7) 47.5 (8.3) 67.4 ( 19. 5) 98 .9 (43 .9) 62.0 (9. 4) 36.0 (18.4) 40.1 ( 19. 3) 176 (41) 5.2 (0 .9) 9. 4 (1.6) 33.3 (1.5)* 62.3 (17.7)* 24.7 (5.4) 71.4 (15 .9) 47.3 (7 .9) 69. 9 ... strength in this patient group QMVC measured on two occasions within weeks of each other in our lab in a group of 15 patients with COPD was 28.8 (9. 2) at baseline and 29. 9 (9. 8) at week follow up with ... difference in the results obtained In addition it was possible in most patients to correlate their reports of exacerbations with the medical notes relating to clinic attendances in the intervening year...

Ngày tải lên: 12/08/2014, 15:20

... successful in increasing lean body mass in patients with COPD In one study [67] an increase in the creatine phosphate/ creatine phosphate + creatine ratio (measured from quadriceps muscle biopsy) ... changes include an increase in mitochondrial number, increased muscle capillarization, and an increase in muscle oxidative enzyme activity After intense training the proportion of type I fibers increases, ... Deconditioning from disuse is believed to be a major contributing factor in the skeletal muscle dysfunction that is observed in patients with COPD Therefore, exercise training in this setting should...

Ngày tải lên: 12/08/2014, 18:20

... prahS 64 99 4- 194 ,33 , 299 1 tcarP minA llamS J yhtapole -ymolydnops lacivrec laduac-emordnys ’relbbow‘ fo noitaulave lacigoloidaR M enofoC ,JS releehW ,HJN prahS 54 352-532 ,11 , 699 1 )minA llamS( ... ,SN swehttaM 73 02-81 ,42 ,99 91 tcarP eninaC yppup enaD taerG a ni sisonets lacivrec ot eud emordnys relbboW M nooM ,S namweN ,J senoJ ,C ettocissaM 63 001- 79 , 391 , 599 1 tteL icsorueN god eht ni ... MIVCA launnA ht91 eht fo gnideecorP yhtapoleym evitarenegeD RJ setaoC 61 1 79- 5 69 ,22 , 299 1 tcarP minA llamS mA htroN nilC teV yhtapoleym evitarenegeD MR snommelC 51 841-541 ,431 ,0 891 ygoloidaR...

Ngày tải lên: 07/08/2014, 18:21

... morphine 0.5 mg/kg, IM After approximately 10 minutes, dissociative anesthesia was induced and maintained with ketamine mg/kg and diazepam 0.5 mg/kg, administered intravenously, with the dogs ... Correlation between thoracic radiographs and postmortem findings in dogs with hemangiosarcoma: 77 cases ( 198 4- 198 9) J Am Vet Med Assoc 199 2, 200:1535-15 39 Ober CP, Barber D: Comparison of two -vs three-view ... anesthesia Anestediology 199 6, 85(Suppl 1): 49- 59 Johnson EG, Wisner ER: Advances in respiratory imaging Vet Clin Small Anim 2007, 37:8 79- 900 Otoni et al Acta Veterinaria Scandinavica 2010, 52:20 http://www.actavetscand.com/content/52/1/20...

Ngày tải lên: 12/08/2014, 18:22

... patients Based on our findings, the co-localization of hSGLT3 with the nicotinic acetylcholine receptor in skeletal muscle at baseline prior to any exercise training, is in accordance with other reports ... that expressed in skeletal muscle Our results using human skeletal muscle suggest that hSGLT3 might be involved in glucose transport following progressive resistance training in diabetic patients ... characterized by insulin resistance, and thus the inability of insulin to stimulate glucose utilization in skeletal muscle It has been proposed that insulin resistant individuals have a defect in GLUT4...

Ngày tải lên: 31/10/2012, 17:08

... 42.38 32 .93 32.75 43.26 39. 79 42.38 29. 63 27.04 20. 69 18.15 5.8 5.2 5.2 5.2 4.7 4.7 6.6 8.8 5.2 6 .9 6 .9 5.0 4.1 P07725 P 990 41 P31001 P 990 41 P58774 P58771 P07310 Q9CP 09 P 990 41 P16015 P17751 P0 597 7 ... in Ca2+-cycling proteins J Mol Cell Cardiol 34, 897 91 8 50 Leong, P & MacLennan, D.H ( 199 8) Complex interactions between skeletal muscle ryanodine receptor and dihydropyridine receptor proteins ... CLP-220 [ 29] , are affected in dystrophin-deficient fibres, this study demonstrates that the main luminal Ca2+-binding protein, calsequestrin, is also greatly reduced in mdx skeletal muscles Hence,...

Ngày tải lên: 19/02/2014, 16:20

... 4.7 2 .9 4 .9 125.1 ± 3.0 142.6 ± 1.2 164.5 ± 3.4 126.7 44.8 14 .9 0 .9 ± ± ± ± 2 .9 3.5 3 .9 1.1 8.3 32.0 89. 9 99 .4 120 .9 ± 3.7 10 .9 ± 1 .9 0.6 ± 0.8 3.3 92 .3 99 .0 a CK content was measured in contralateral ... M lines and downregulation of creatine kinase in mouse extraocular muscle J Appl Physiol 95 , 692 – 699 38 Rostworowski M, Balasingam V, Chabot S, Owens T & Yong VW ( 199 7) Astrogliosis in the neonatal ... was developed in the hind leg of mice by injecting 3MC, a chemical carcinogen, or by injecting into the hind leg existing sarcoma 180 cells, which had been previously maintained in the peritoneal...

Ngày tải lên: 07/03/2014, 06:20

... calpain was investigated A direct, in vitro digestion of CARP by calpain using recombinant proteins could not be attempted because calpain is inactivated during purification [45] In skeletal muscle ... more efficiently bound to titin after cleavage by calpain (P < 0.01; Fig 2E) It is worth noting that, in skeletal muscle, an endogenous inhibitor maintains calpain in an inactive state until a signal, ... Suzuki K ( 199 7) Muscle- specific calpain, p94, interacts with the extreme C-terminal region of connectin, a unique region flanked by two immunoglobulin C2 motifs Arch Biochem Biophys 342, 99 –107 16...

Ngày tải lên: 29/03/2014, 21:20

... in skeletal muscles, and promotes muscle differentiation if induced by MyoD and myogenin during myogenesis [16,17] These muscle- specific miRNAs seem to participate in muscle diseases, including ... variability in the Utrophin level both in controls and DM1 Figure Western blot analysis showing the Utrophin and α-Tubulin protein expression levels in DM1 patients and controls Utophin/Tubulin ratios in ... the most severely affected muscle in the dystrophin-deficient mouse They observed an increase in miR-206 expression in this muscle, associated with a similar increase in Myod1 expression These...

Ngày tải lên: 18/06/2014, 16:20

... sensorimotor integration Science 199 5, 2 69: 1880-1882 Kawato M: Internal models for motor control and trajectory planning Curr Opin Neurobiol 199 9, 9: 718-727 Wolpert DM, Miall RC, Kawato M: Internal ... 3. 690 3 21 (s06) (s03) 15 7 .94 02 19 10 (s 19) (s15) 23 4.7744 20 (s 99) (s23) 3. 691 91 18 N/A (s04) 12 5.2 697 7 19 (s15) (s12) 21 4.77444 21 (s24) 13 (s21) 8.5 693 7 16 (s 09) (s04) 15 21.3752 15 (s18) ... measurements are listed in the following sequence, together with the corresponding object: ADL task #1 Drinking a glass (no reaching): the arm is placed close to the body, close to the mid line, the position...

Ngày tải lên: 19/06/2014, 08:20

... the body mass in mice [ 19] , the observed insulin-induced increase in plasma clearance rates can be attributed to an increase in skeletal muscle FDG uptake and, thus, an increase in whole- body ... Myocardium Muscle Brain Non-fasted 9. 5 ± 2.4 0.55 ± 0.11 1.45 ± 0.41 Non-fasted and insulin Fasted 9. 98 ± 1.06 3.48 ± 1.73* 0 .97 ± 0. 29* 0.40 ± 0. 09 0 .96 ± 0.11* 2.87 ± 0.50* Fasted and insulin 9. 35 ... concentrations in the four groups of mice In both insulin groups FDG cleared from plasma more rapidly than in the groups without insulin injection Y axis is in logarithmic scale The insulin injected...

Ngày tải lên: 21/06/2014, 02:20

... Cancer 199 8, 78, 99 3-1003 12 Schuchter LM Guidelines for the administration of amifostine Semin Oncol 199 6, 23, 40-43 13 Weil MM, Stephens LC, Amos CI, Ruifrok AC, Mason KA Strain difference in jejunal ... to radiation-induced apoptosis Int J Radiat Biol 199 6, 70, 5 79- 585 14 Withers HR, Elkind MM Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation Int J Radiat Biol ... Vijayalaxmi Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation Mol Cell Biochem 2000,...

Ngày tải lên: 07/08/2014, 20:24

... resulting in a relative lack of insulin in vivo [ 29, 32,33] Hu et al [14] found that insulin deficiency activated the Ub-proteasome system, resulting in cardiac muscle protein catabolism in diabetes ... al: Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription J Clin Invest 199 6, 98 (8):1703-8 ... Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle J Clin Invest 199 7, 99 (2):163-8 28 Tisdale MJ: The ubiquitin-proteasome pathway...

Ngày tải lên: 11/08/2014, 06:23

... sensorimotor integration Science 199 5, 2 69: 1880-1882 Kawato M: Internal models for motor control and trajectory planning Curr Opin Neurobiol 199 9, 9: 718-727 Wolpert DM, Miall RC, Kawato M: Internal ... 3. 690 3 21 (s06) (s03) 15 7 .94 02 19 10 (s 19) (s15) 23 4.7744 20 (s 99) (s23) 3. 691 91 18 N/A (s04) 12 5.2 697 7 19 (s15) (s12) 21 4.77444 21 (s24) 13 (s21) 8.5 693 7 16 (s 09) (s04) 15 21.3752 15 (s18) ... measurements are listed in the following sequence, together with the corresponding object: ADL task #1 Drinking a glass (no reaching): the arm is placed close to the body, close to the mid line, the position...

Ngày tải lên: 11/08/2014, 08:21

... Musculoskeletal involvement in cystic echinococcosis: report of eight cases and review of the literature Am J Roentgenol 199 7, 168:1531-1534 Tüzün M, Hekimoglu B: CT findings in skeletal cystic echinococcosis ... considered in the differential diagnosis of osteolytic lesions in radiological imaging as well as single or multiple abnormal uptakes in the whole body bone scan especially among people living in endemic ... uptake in the lower Whole body bone Scintigramright knee lumbar spine, the Whole body bone Scintigram showed multiple foci of increased radiotracer uptake in the lower lumbar spine, the left sacroiliac...

Ngày tải lên: 11/08/2014, 10:22

... bleeding from the puncture site because of inadequate hemostasis [3] Also, urinary contamination is a relatively common finding in whole body bone scan (WBBS) [3] Sometimes the body or clothing ... clothing Figure ing contamination activity at the region of the scan shows linear to bed clothPosterior whole body bone left lower ribs due increased Posterior whole body bone scan shows linear increased ... from detector contamination by its limited area of involvement since detector contamination appears as a line throughout the whole body on the total body projection [2] Our findings suggest that...

Ngày tải lên: 11/08/2014, 10:22

... HAART since 199 7: zidovudine 300 mg twice a day (bid) plus lamivudine 150 mg bid plus indinavir 800 mg three times a day from July 199 7 to July 2001, changed for simplification; zidovudine 300 ... creatinine level at this time was 1.7 mg/dl Case presentation A 48-year-old Caucasian woman was diagnosed with HIV1 infection in 199 2 Past medical history included primary amenorrhea ( 197 0), ... serum creatinine level had a peak of 1.8 mg/dl (normal range: 0.5-1.3), and it was 1.7 mg/dl (estimated clearance creatinine 59. 4 ml/ min) just before starting the new tenofovir-containing regimen...

Ngày tải lên: 11/08/2014, 14:20