... carnitine: 1 mm (for standard comparison with other published data), and a concentration equal to the K m for carnitine of each enzyme (for comparison between mutants). In this article, we show ... sequence as being responsible for the pecu- liar kinetic characteristics of this enzyme, acting as a negative determinant for malonyl-CoA sensitivity. Asp17 may account, at least in part, for the high degree ... nat- urally occurring variation, Glu17, is responsible for both the low malonyl- CoA sensitivity and high carnitine affinity characteristics of the pig enzyme. This is the first demonstration that a single...
Ngày tải lên: 16/03/2014, 04:20
... active conformation, Val371 forms contacts with neighboring residues that are important for stabi- lizing the active state (e.g. Asp189, which is part of the S1 pocket responsible for the binding ... substitution of Val371 to isoleucine might prevent the full development of the active conformation. This hypothesis is further con- firmed by the results of FIX proteolytic assays, which showed a slight ... sequence identity of 30–45%), this position is occupied solely by a valine. This conserved amino acid is replaced by isoleucine in the Val371Ile FXI mutant. Interestingly, an isoleucine residue natu- rally...
Ngày tải lên: 23/03/2014, 07:20
Báo cáo khoa học: Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx
... factor that favors lysogeny and is responsible for primary control of the lambda develop- mental decision for lysis or lysogeny [4,7–9]. In the absence of CIII, CII is rapidly degraded by the ATP- dependent ... However, this proteolysis is much slower in vitro, because of a lack of chaperone machin- ery. The in vitro proteolysis requires ATP [14]. We examined the proteolysis of purified r 32 -C-his (1.2 ... on proteolysis of the heat shock sigma factor r 32 , another substrate of HflB. Like proteolysis of CII, r 32 proteol- ysis requires ATP. Both CIII and CIIIC inhibit this proteolysis, with CIIIC...
Ngày tải lên: 23/03/2014, 10:20
Báo cáo khoa học: PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast pdf
Ngày tải lên: 29/03/2014, 22:21
Which citizens is exempting for Vietnam visa vietnam-immigration.org.vn pot
Ngày tải lên: 19/06/2014, 08:20
Báo cáo y học: " JNK activation is responsible for mucus overproduction in smoke inhalation injury" potx
Ngày tải lên: 12/08/2014, 13:22
Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx
... prior to hydrolysis. The low-affinity state was observed to be retained immediately post-hydrolysis. Therefore, the dissoci- ation of phosphate and ⁄ or ADP is likely to be responsible for resetting of ... high-affinity conformation for the transporter, which is supported by the restoration of high-affinity binding in the ADP- bound conformation. That this step of the catalytic cycle is associated ... of ATP per se is the ‘power stroke’ for drug translocation, and that energy obtained from the hydrolysis process is used to reset the transporter. That ATP binding is responsible for the shift...
Ngày tải lên: 18/02/2014, 18:20
Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... hydrolysis), corresponding to that expected for the F variant. This result is the first evidence for the heterozy- gous status (M/F) of the individual goat milk analysed. In addition to this, t ... first one is an ACRS-PCR technique [26], the principle of which is to create a TaqI restriction site (TCGA) by using a mismatching primer (C9LM*) which allows both the F and M alleles to be discriminated ... subsequently distin- guished after a second amplification which allows discrim- ination between the alleles on the basis of the f ragment sizes (Fig. 8 , Step IIA). In the first step, a 266-bp (265 bp for...
Ngày tải lên: 22/02/2014, 04:20
Báo cáo hóa học: "TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status" pot
Ngày tải lên: 18/06/2014, 16:20
Which Sound Is Different?
... 4. A. ought B. bough C. thought D. brought 5. A. spoor B. door C. floor D. force 6. A. poisonous B. noise C. tortoise D. buoy 7. A. golf B. adulthood C. wood D. bosom 8. A. wool B. mood C. took ... scheme C. skeptical D. schematic 7. A. bronchitis B. chestnut C. chronometer D. chrisma 8. A. chauvinism B. exchange C. teacher D. childrearing 9. A. bristle B. indict C. Connecticut D. Vinci 10. ... D. foreign 10. A. gnome B. assignment C. designer D. magnificent SOUNDS 15 1. A. locate B. geologist C. horizon D. gallop 2. A. rough B. tough C. through D. much 3. A. environment B. information...
Ngày tải lên: 26/06/2013, 01:25
Which Sound Is Different?
... scheme C. skeptical D. schematic 7. A. bronchitis B. chestnut C. chronometer D. chrisma 8. A. chauvinism B. exchange C. teacher D. childrearing 9. A. bristle B. indict C. Connecticut D. Vinci 10. ... 4. A. ought B. bough C. thought D. brought 5. A. spoor B. door C. floor D. force 6. A. poisonous B. noise C. tortoise D. buoy 7. A. golf B. adulthood C. wood D. bosom 8. A. wool B. mood C. took ... D. foreign 10. A. gnome B. assignment C. designer D. magnificent SOUNDS 15 1. A. locate B. geologist C. horizon D. gallop 2. A. rough B. tough C. through D. much 3. A. environment B. information...
Ngày tải lên: 27/06/2013, 11:46
What is the question to which ‘substitution’ is the answer
... that either one is responsible for everything or one has refused responsibility. This is how Levinas answers those who say that to be responsible for everything is to be responsible for nothing. In ... on this account, but that does not mean that the relation to being in which the ethical is situated is not crucial. This is why it is not irrelevant what is said in the saying, just as it is not ... toward the concrete, which is where the encounter takes place. The point is not just to show that such acts are impossible for an existence that is concerned only for its own existence, as they would...
Ngày tải lên: 01/11/2013, 10:20