what are you developing and why

... mutations are known, and only a handful are nonsense mutations or involve the replacement of a residue in the active site of GCase The vast majority of the disease-causing mutations occur randomly ... protein crystallography: liganded proteins tend to crystallize more readily than their unliganded counterparts because their structures are more stable Therefore, the obvious candidates for specific ... [23-25], and 1-deoxygalactonojirimycin for Anderson-Fabry disease [26] All these compounds are analogs of normal physiological substrates or reaction products that interact with these proteins, and...

Ngày tải lên: 06/08/2014, 19:21

... continue answer: Your Your Incorrect - Click anywhere Incorrect - Click anywhere to continue to continue You did not answer this You did not this correctly! You answered answer this You question ... continue answer: Your Your Incorrect - Click anywhere Incorrect - Click anywhere to continue to continue You did not answer this You did not this correctly! You answered answer this You question ... continue answer: Your Your Incorrect - Click anywhere Incorrect - Click anywhere to continue to continue You did not answer this You did not this correctly! You answered answer this You question...

Ngày tải lên: 09/07/2015, 13:41

... writing • Ride a bicycle  Riding a bicycle What are you doing? I’m watching TV What are you doing? I’ m writing a letter Are you reading a book? Yes, I am Are you reading a book? No, I’m not I’m drawing ... I’m a student No, I’m not I’m riding a bicycle They are 50.000 dong I’m a student 10 I’m drawing a picture 1 What/ watch TV Ride a bicycle/ Yes What/ write a letter Draw a picture/ No/ Read a book...

Ngày tải lên: 17/10/2013, 02:11

... If something goes wrong with your products, you simply show your recipt and you are given a new one or your money back Not to forget about sales and special offers such as "buy one get ... supermarkets id that it is time consuming and it takes a while to getthere and back Big stores are also quite dangerous for all small shops owned by private people And those shops may be the only source ... which rather possitive I think that supermarkets are great creatures and the more of them the better It is a good way to spend your free time and relax shopping ...

Ngày tải lên: 23/10/2013, 02:15

... clear about what you conclude and why you are concluding it Do not hide your conclusion and reasons; display them openly Give the audience a clear opportunity to see what you intend Thus, your task ... to speak to us What Are the Reasons? 33 Critical Thinking and Your Own Writing and Speaking When you are writing or speaking, you will want to keep your audience foremost in your plans They ... QUESTION IS IMPORTANT What Are the Reasons? Once you have identified the issue and conclusion, you need to understand why an author has come to a certain conclusion Reasons are the why If the author...

Ngày tải lên: 25/10/2013, 15:20

... Working Paper Fiscal Affairs Department Government Bonds and Their Investors: What Are the Facts and Do They Matter?1 Prepared by Jochen R Andritzky Authorized for distribution by Martine Guerguil ... Ireland, and Spain While other intragovernmental holdings are often available for other countries, social security and public pension fund holdings are readily available only for Canada and Japan ... Author’s E-Mail Address: jandritzky@imf.org Comments and helpful thoughts are gratefully acknowledged from Serkan Arslanalp, Max Fandl, Martine Guerguil, Manmohan Kumar, Andre Meier, Christian Schmieder,...

Ngày tải lên: 15/03/2014, 07:20

... Advertising can inform people about different products and services and their utilities, cost and other requirements It helps consumers know what is the best option for them INFORMATIVE ENTERTAINING ... 1102015020 1102015077 1102015048 0802021117 TOPIC 13 By what means can a product or a servicebe advertised? Briefly present the strengths and weaknesses of each means  A product or a service can ... customers watch television many times a day so they can easily recognize brand name of the suppliers  The customers are very impressed by the images that the suppliers advertised in the television...

Ngày tải lên: 02/06/2014, 15:10

... khác Bắt đầu câu hỏi: What are you doing tomorrow? STEVE What are you doing tomorrow? Tất nhiên, ta dùng thời gian nòa, như: What are you doing on the weekend? What are you doing tonight? Nếu ... movie with you hay I’d like you to come to dinner hay I was wondering whether you wanted to go to a movie hay I was wondering if you d like to come to dinner STEVE Well I have the day off, and I was ... speaking How may I help you? Sau nói tên mình: CLERK Medina Hotel Marie speaking How may I help you? Và sau hỏi xem bạn giúp cho họ: CLERK Medina Hotel Marie speaking How may I help you? May khác trang...

Ngày tải lên: 12/07/2014, 03:20

... of barriers and facilitators derived from the questionnaires; gain in-depth understanding as to ‘how’ the barriers and facilitators influenced implementation; and gather new barriers and facilitators ... network, opinions of colleagues, and leadership); organisational (i.e., staff, capacities, and resources); and economical and political context (i.e., regulations, policies, and financial arrangements) ... Work and Health, VU University Medical Center, van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands 2Department of Public and Occupational Health, EMGO Institute for Health and Care Research,...

Ngày tải lên: 10/08/2014, 10:23

... writing • Ride a bicycle  Riding a bicycle What are you doing? I’m watching TV What are you doing? I’ m writing a letter Are you reading a book? Yes, I am Are you reading a book? No, I’m not I’m drawing ... I’m a student No, I’m not I’m riding a bicycle They are 50.000 dong I’m a student 10 I’m drawing a picture 1 What/ watch TV Ride a bicycle/ Yes What/ write a letter Draw a picture/ No/ Read a book...

Ngày tải lên: 10/08/2014, 11:20

... when you drag a movie clip onto the stage, you' re actually creating an instance of the MovieClip class When you create a dynamic text field, you' re creating an instance of the TextField class You ... a car has properties like color, make, model, and horsepower If your project had a Car class and you had created an instance of it named myCar, you might access the value of its properties in ... important to realize that when building your Flash projects, you create and use instances of various classes of objects, rather than placing the actual class in your project It's a subtle but important...

Ngày tải lên: 20/10/2013, 14:15

... economists What is the economist seeing? What could he tell you, if you cared to ask? And why should you care? You may think you re enjoying a frothy cappuccino, but the economist sees you and the ... very little, and some of them are after the money in your pocket right now The economist can tell you who will get what, how, and why My hope is that by the time you finish this book, you ll be ... meadowland and the marginal land (in this case, the scrubland) When Cornelius arrived, the grassland became the marginal land, meadows became yet more attractive relative to the marginal land, and...

Ngày tải lên: 11/06/2014, 02:14

... means that you have to have good people in place around you And let’s suppose that you have liked what you ve been doing, but the years have gone by, and now you re getting bored How are you going ... elusive Chapters 4, 5, and address the whens, whats, and wheres: when to look, what to look for, and where you re likely to find what you re looking for Throughout these chapters (and elsewhere in the ... of your potential happiness, the remaining factors are very much under your control Most important among these, he says, are your personal relationships and your level of satisfaction with your...

Ngày tải lên: 28/06/2014, 21:20

... means that you have to have good people in place around you And let’s suppose that you have liked what you ve been doing, but the years have gone by, and now you re getting bored How are you going ... elusive Chapters 4, 5, and address the whens, whats, and wheres: when to look, what to look for, and where you re likely to find what you re looking for Throughout these chapters (and elsewhere in the ... explains (for example) why some things are easy for you to learn, while others are extremely difficult Genetics set limits on you, even as they open doors for you But they are not exactly static...

Ngày tải lên: 10/08/2014, 07:21

... of your potential happiness, the remaining factors are very much under your control Most important among these, he says, are your personal relationships and your level of satisfaction with your ... explain why mastering great people decisions is almost certain to have an enormous impact on your own chances of career success I hope you are now convinced that stellar managerial careers are built ... articles, many executives today are embarking upon second careers.35 Let’s assume that you re one of these “self-restarters.” No matter what your reason—whether you are seeking more flexibility,...

Ngày tải lên: 10/08/2014, 07:21

... Let’s assume that you know exactly where you stand, and (based on that understanding) you know exactly what you need to do, in terms of the people changes that are required to move your organization ... and that you truly want the best outcome for your organization Well, if that’s true, then your real challenge is to make your processes transparent and predictable—in other words, to reflect your ... conclusions, and that what may work as a rule may be the worst remedy for your specific situation Keep your eye on the real challenge and the real solution What really accounts for your company’s...

Ngày tải lên: 10/08/2014, 07:21

... significantly in the future, and therefore take on larger challenges As I see it, potential consists of three main components First, of course, you need ambition Are you hungry? What are you aspiring to, ... relationships and social capital The final reason why it is very important to define what you are looking for with a team perspective in mind is that, in many cases, you simply can’t find Superman, Batman, and ... What to Look For 155 Knowing what to look for is important because • Some characteristics are better predictors of success • You need to focus your efforts • You will avoid discrimination • You...

Ngày tải lên: 10/08/2014, 07:21

... limits on people decisions You can’t choose an alternative you are unaware of, and you can’t choose an alternative better than the best of those who are put before you In a perfect world, an ... some outstanding successes and some formidable failures So you should be particularly careful, when things are going well, to look at the future, and make sure that the person you are promoting ... make your final choice, you would need to interview at least 38 women (37 + 1) on a base of 100, and most likely, many more And what if your base is 1,000 candidates, rather than 100? Do you have...

Ngày tải lên: 10/08/2014, 07:21

... that you were responsible for implementing How did you handle it? What resulted from it? Would you handle it any differently now? ? Given our organizational culture and the changes we need, can you ... communications project you ve led How did you measure results? ? Describe a time you led a team to be more effective What did you do? How did the team and the organization benefit from your actions? ? ... people who have the right motivation, and are given opportunities to practice and receive proper feedback Developing your assessment skills will be key for your career success, as discussed in Chapter...

Ngày tải lên: 10/08/2014, 07:21

... conviction If you have done your homework, understand the candidate’s motivation, and are convinced that what you are offering is the best for her, (almost) nothing will stop you In most cases, you will ... concerns, and share your passion about your company, your projects, and the job you are offering Anyone can hire average people Anyone can hire people who are on the market, and are hungry But ... understand his or her career alternatives Only if you become convinced that what you are offering is the best for the candidate will you be able to attract that candidate Sharing Your Passion Nothing...

Ngày tải lên: 10/08/2014, 07:21