... Plasma ProteinsHaving entered the blood, drugs maybind to the protein molecules that arepresent in abundance, resulting in the formation of drug-protein complexes.Protein binding involves primarily ... from binding sites onplasma proteins. Binding to plasma pro-tein is equivalent to a depot in prolong-ing the duration of the effect by retard-ing elimination, whereas the intensityof the effect ... area inthe sche-matic drawing, bottom left) and acts asa continuous barrier between the twospaces separated by the cell layer – in the case of the gut, the intestinal lumen(dark blue) and the...
... like they expected a receipt.—K IN HUBBARD, humorist (1868–1930)Two Sides of the Same Coin In Mandarin the words buy and sell are the same inthe spo-ken language, differing only inthe ... actually the name of a muscle. Its claim to fame is thatit’s the largest muscle inthehuman body. Can you guess where onecan find it? Hint: you sit on it. An incredible machine, the human body ... in the face of overwhelming complexity.” The SciencesMISCELLANEOUS WORDS99 In a perfect union the man and woman are like a strung bow.Who is to say whether the string bends the bow, or the...
... mainly cropping rice and fruits. Some of the farms maintain small animal husbandries and fishponds. Surface water, rain water and ground water are used for the drinking and the domestic water ... concept for the rural drinking water supply. Inthe focus of this survey were two exemplary study sites inthe rural area of the Mekong Delta. The objective of this paper is the appraisal of the hydrological, ... for the ground water samples in An Binh and Hoa An in mmol(eq%)/l 1Conditions of the surface water and ground water resources inthe rural area of the Mekong Delta, Vietnam – exemplary investigations...
... bygrowth in iron-rich media. We have also shown that the increase inthe prooxidant state caused by ironloading has an impact in protein integrity, as indicatedby an increase in protein-bound ... localizes inthe cytoplasm of human epithelial cells of the gastrointestinal tract andliver, two central organs inthe regulation of ironmetabolism [20,21]. After their synthesis inthe endo-plasmic ... 5 min, and washed in running tap water for 5 min. Then, sections were incuba-ted in 85% (v ⁄ v) propyleneglycol for 2 min (the solutionwas changed twice) and in Oil Red O [0.5% (v ⁄ v) in pro-pyleneglycol]...
... significant increase in rainfall in wet season resulting in an increase in river flow. By contrast, the decreasing trend of river flow in dry season is a consequence of the decline of rainfall and increase ... than 30% of thehuman population of Thua Thien - Hue Province. Climate change impacts on the coastal zone in the province include: (1) The shrinking of land and coastal plain due to enlarged ... 0.4 0.6 0.8 1.0 1.2 1.5 2.0 2.5 Results also indicate that rainfall inthe rainy season would increase by 25%. In contrast, rainfalls inthe early months of dry season (December to February)...
... construct water supply infrastructure in return for mining concessions in Katanga.52 The Management Platform for Aid and Investments (PGAI) coordinated by the Ministry of Planning brings together ... Pygmies draw drinking water directly from natural springs in Ituri forest4 7Water Issues inthe Democratic Republic of the CongoWork in progress: construction of a retaining headwall inthe village ... to the long-term sustainability of major infrastructure investments inthewater sector. The immediate challenge on the ground is the non-application of basic zoning principles and land delineation...
... antibody, appeared at90 kDa. Loading control was performed using an antibody against b-actin, which produced a band at 42 kDa. The data indicate the intensityof the HLA-G band related to the ... an increase in binding capacity[25].Identification of nitration site inthe extracellulardomain of ILT2 In the extracellular domain of ILT2, there are severalTyr residues that participate in ... directly inthe interaction with HLA-G [3,19]and Tyr35 is located inthe very vicinity of Tyr38.These modifications should affect the binding pocketdirectly. Furthermore, Tyr99 stabilizes the anglebetween...
... the initial GS activitywas maintained (116.5 ± 7.3% of the initial activity). The protective effect was abolished when the recom-binant protein was heat-inactivated by autoclaving,suggesting ... FEBSprotein bound to the agarose. This binding was con-firmed by the observation that only a trace of the pro-tein was left inthe unbound fraction. Pre-incubation of the recombinant protein with ... but the bindingwas not affected by preincubation of the protein withFP. These results also indicate that Pf1-Cys-Prx canbind to FP at pH 7.4, which is the pH of the parasitecytosol. The fact...
... by the main system in periods of drought. In low-lying parts of the Netherlands, thewater that enters the system has a variety of functions, the most important of which is maintaining thewater ... and understanding of those abroad, who are interested inthe particularities of water management inthe Netherlands. Water Management in the Netherlands Water Management inthe Netherlands | ... within the ring and if the number of inhabitants is high. Other important factors are the size of the area liable to flooding; the height to which thewater may rise and whether the flood water...
... gins, or delays the analysis, i.e., determines structure only after further material of the string is received. The other feature is whether the model constructs just a single analysis of the ... garden-pathing at the point of disambiguation (the word "to"). Inthe present experiment, sentences in which the "that"-clause was disambiguated immedi- ately following the beginning ... GSP does so in a limited way. Their Final Ar- guments principle permits a delay inthe determina- tion of the attachment of particular constituents into the overall structure of the sentence...
... provides the residues forbinding the coenzyme. The C-terminal domain has a lar-gely a-helical structure, and serves mainly in substratebinding. The active site is located inthe interdomaincleft, ... (40–800 mm), and so the choice of the constantlevel of Fru was not critical for determination ofDKm(1.23 ± 0.15). The KIE data in Table 4 are instrumen-tal in delineating the kinetic mechanism ... Considering the uncertainty inthein vivolevels of NADH, Fru and Man-ol1P used, we per-formed a sensitivity analysis in which the effects ofchanges in intracellular reactant concentrations on the thermodynamic...
... protein of SUMO modification[32,33]. The hinge region lysine, residue 289 in the mouse and 224 inthehuman LRH-1, was the majorSUMO conjugation site. Sumoylation of LRH-1 isassociated with the ... Nuclear body localization of LRH-1 was suppressed by forskolin and cholera toxin.Forskolin treatment obviously in uences the expression of membersinvolved inthe SUMO pathway. The results obtained ... is attenuated by the cAMP signaling pathway. Our studies further indicatea novel regulatory mechanism of cAMP signaling foraltering the sumoylation cycle, involving modulating the expression...
... repression. These results thus demon-strate a strong conservation inthe binding of C-terminal binding protein-interacting domains despite great variability in their amino acid sequences.Finally, ... cleft inthe CtBP N-terminalregion.Point mutation of the only invariant residue in the CtBP-interacting domain is sufficient toabolish the HIC1–CtBP interactionHaving established that the interaction ... CtBP (C-ter-minal binding protein) through a conserved GLDLSKK motif, a variant of the consensus C-terminal binding protein interaction domain PxDLSxK ⁄ R.Here, we show that HIC1 interacts with...