van de loosdrecht et al 2004

... mitochondrial transmembrane potential Dwm Changes in the mitochondrial potential were detected with the potential-sensitive probe dihexyloxacarbocyanine iodide (DIOC6) uptake [49] Dwm was determined ... imaging, analysis and MS 2DE was performed as described previously by Ummanni et al [22] Briefly, to prepare samples for analytical 2DE, 150 lg of protein sample of each patient were made up to ... activation of caspase cascade in LNCaP cells Cell death was analysed by flow cytometry Propidium iodide (PI) was applied to LNCaP cells depleted for TPD52 expression to measure cell death Based on the...

Ngày tải lên: 30/03/2014, 02:20

Ngày tải lên: 01/04/2014, 13:20

... peripheral and central disorders This book therefore takes an integrated approach to disorders of the auditory system While most disorders of the auditory system have detectable morphologic abnormalities, ... Canal 20 3.1 Ear Canal 20 3.2 Head 20 3.3 Physical Basis for Directional Hearing 21 v vi Contents CHAPTER Sound Evoked Electrical Potentials in the Cochlea Abstract 57 Introduction 57 Electrical ... been added A separate chapter is devoted to an extended coverage of hyperactive disorders, most importantly tinnitus, the cause and treatment of which is discussed in detail A new chapter describes...

Ngày tải lên: 11/08/2014, 06:21

... pressure in the sealed ear canal is varied is known as tympanometry Tympanometry has found widespread clinical usage as a diagnostic tool because it provides a non-invasive way to determine the pressure ... in the ear canal are usually expressed in acoustic admittance (also known as immittance) Tympanometry also provides information about the function of the middle ear in general Usually the acoustic ... allowed such extrapolations of these experimental findings (Readers who are interested in details about the development of hypotheses and experimental studies of the cochlea as a spectrum analyzer...

Ngày tải lên: 11/08/2014, 06:21

... system to process very small time intervals (see p 117) In order to use that temporal code to determine the frequency of a sound, the nervous system must determine the interval between nerve impulses ... of sound This model is based on auto correlation analysis to determine the intervals between sound waves The auto correlation model for decoding time intervals requires a set of delays and multiplies ... system can detect very small time intervals (or rather very small differences in time intervals) Time differences in the order of µS between the arrival of sounds at the two ears can be detected...

Ngày tải lên: 11/08/2014, 06:21

... vertically but the resolution of these vertical components did not allow determination of their exact location, nor was it possible to determine whether they were located ipsilaterally or contralaterally ... results using several different methods has provided the following general description of the neural generators of vertex positive peaks of the click evoked ABR recorded between electrodes placed on ... amplitude of the ABR Recording parameters, filtering of the recorded potentials, individual variations some of which are related to age and size of the head, all influence the recorded potentials...

Ngày tải lên: 11/08/2014, 06:21

... distinction between peripheral and central causes of symptoms is blurred and it is no longer valid to divide disorders of the auditory system according to the anatomical location of the detectable ... clinical useful division, it has become evident that the anatomical location of the physiological abnormalities that cause hearing impairment is not localized only to the structures that have detectable ... 92: 73–82, 2004 45 Erulkar SD, Nelson PG, and Bryan JS Experimental and theoretical approaches to neural processing in the central auditory pathway New York: Academic Press, 1968 46 Evans EF Frequency...

Ngày tải lên: 11/08/2014, 06:21

... manifest as differences in the physical characteristic of genetically identical organisms Naturally, environmental factors can also affect the development of an animal These factors (epigentics and ... diagnostic methods There is also a geographical dependence, and since the incidence increases with age, it will depend of the longevity of a population monitoring [212] While surgical removal of these ... exposure under controlled laboratory conditions shows individual variation (Fig 9.15) These variations in NIHL in genetically identical animals can be explained by difference in epigenetics1 [140]...

Ngày tải lên: 11/08/2014, 06:21

... 2003 62 De Ridder D, De Mulder G, Walsh V, Muggleton N, Sunaert S, Verlooy J, Van de Heyning P, and Møller AR Transcranial magnetic stimulation for tinnitus: a clincial and pathophysiological approach: ... vitamin D Individuals with WBS have multiple congenital anomalies, such as cardiovascular disorders, prenatal and postnatal growth retardation, facial abnormalities and mental retardation including ... way we normally understand it, they did indeed provide valuable sound awareness to people who were deaf and provided an aid in lip-reading Modern multi-electrode implants can provide good speech...

Ngày tải lên: 11/08/2014, 06:21

... partially protected peptide degrades when purified by HPLC All measured peptide masses are in agreement with the calculated mass values (Table 1) Competitive binding assays All three peptide conjugates ... labeled with radiometals and used for PET imaging of GRPR-positive tumors Schuhmacher et al labeled a 1,4,7,10-tetraazacyclododecane-N,N’,N’’,N’’’-tretraacetic acid [DOTA]-PEG [polyethylene glycol]2-BBN(6-14) ... distance between the two peptide motifs The ability of a dimer peptide to achieve bivalency depends also on the receptor density [25] If the receptor density is very high, the distance between two...

Ngày tải lên: 21/06/2014, 17:20

... ketoconazole, diethylstilbestrol, estramustine, and transdermal b-estradiol, along with a trial of low-dose oral cyclophosphamide and capecitabine, all while he was being treated with leuprolide maintenance ... important metabolic interactions demonstrated by Smulders et al [13] involving vitamin B 12 and reduced folates included the folate and vitamin B12 dependence of the conversion of homocysteine to methionine ... and meta-analysis Cancer Epidemiol Biomarkers Prev 2010, 19:1632-1642 17 Collin SM, Metcalfe C, Refsum H, Lewis SJ, Smith GD, Cox A, Davis M, Marsden G, Johnston C, Lane JA, Donovan JL, Neal DE, ...

Ngày tải lên: 10/08/2014, 23:20

... (Coleman et al. , 2000; DeGrado et al. , 2001; Hara, 2001; Price et al. , 2002; Kwee et al. , 2004; Kwee et al. , 2005; Schmid et al. , 2005; Cimitan et al. , 2006; Heinisch et al. , 2006; Kwee et al. , 2006; ... dominated by choline transport although dual time PET is dependent also on choline kinase activity via metabolic trapping (Henriksen et al. , 2004) In dual time PET, choline retention is measured at ... and Degani, 1996; DeGrado et al. , 2001; Hara et al. , 2002; Katz-Brull et al. , 2002) Choline kinase is known to be overexpressed in lung, colorectal, and prostate cancers (Ramirez de Molina et al. ,...

Ngày tải lên: 24/08/2014, 10:38

... small enclosed spaces B Inadequate local or general ventilation that results in insufficient dilution or removal of infectious droplet nuclei C Recirculation of air containing infectious droplet ... transmitted Space Exposure in small, enclosed spaces Ventilation Inadequate local or general ventilation that results in insufficient dilution or removal of infectious droplet nuclei Air circulation ... less than 90% of their ideal body weight; • Cigarette smokers and persons who abuse drugs and/or alcohol; and • Populations defined locally as having an increased incidence of disease due to M...

Ngày tải lên: 15/02/2014, 12:20

... Squalene Pyruvate HMG-CoA Acetyl-CoA ACL Oxaloacetate Citrate Cholesterol synthesis HMG-CoA reductase Oxaloacetate Citrate SREBP-2 Cholesterol Malate HMG-CoA synthase acetyl-CoA ACC Malate Malonyl-CoA ... Hagen T, Vidal-Puig AJ, Boss O, Kim YB et al (2001) Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type diabetes Cell ... M, Hasty AH et al (2008) Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets Diabetes 57, 2382–2392 40 Sun L, Halaihel N, Zhang...

Ngày tải lên: 18/02/2014, 13:20

... lying down, for The directional anatomical terms are cranial, caudal, ventral, dorsal, medial, lateral, proximal, distal, superficial, and deep They are used to identify the position of body ... internal Bones are deep to skin Superior (cranial) Midline Dorsal (posterior) Lateral Ventral (anterior) Medial Deep Proximal end of forearm Distal end of forearm Proximal end of thigh Superficial ... Occipital (back of head) Umbilical (navel) Inguinal (groin) Dorsum (back) Cubital (elbow) Lumbar (lower back) Sacral (between hips) Coxal (hip) Gluteal (buttocks) Perineal Palmar (palm) Digital (finger)...

Ngày tải lên: 06/03/2014, 07:20

... vital fluid Let us not forget in this connection, the statement made above: that the testis produces two forms of secretion, the internal secretion and the external secretion, the internal secretion ... Physically this animal develops a body almost identical with that of the female of the same[62]species Temperamentally the gelding is a patient, plodding, beast of burden, and though under good ... CONTRIBUTION ALKALINE AND (In quantity greater SALTS than all the rest.) WATER PROSTATIC PROTEINS CONTRIBUTION ALKALINE (Viscid opalescent.) and SALTS WATER [43] Plate II Male Sexual Apparatus...

Ngày tải lên: 06/03/2014, 13:20

... nodes N3 Metastasis to contralateral medastinal, contralateral hilar, ipsilateral or contralateral scalene or supraclavicular lymph nodes Distant metastasis (M) MX M0 M1 Presence of distant metastasis ... ipsilateral and contralateral supraclavicular lymph nodes • involves ipsilateral and contralateral mediastinal lymph nodes • can be with or without ipsilateral pleural effusions, independent of ... ipsilateral primary-tumour lobe of the lung NICE Guideline – lung cancer 37 Regional lymph nodes (N) NX Regional lymph nodes cannot be assessed N0 No regional lymph node metastasis N1 Metastasis...

Ngày tải lên: 15/03/2014, 00:20

... are divided into metallic and non-metallic substances The metallic substances are Po-tas´si-um, So´di-um, Cal´ci-um, Mag-ne´si-um, A-lu´minum, I´ron, Man´ga-nese, and Cop´per The non-metallic substances ... distinction between plants and animals is also of much importance Animals grow proportionally in all directions, while plants grow upwards and downwards from a collet only The food of animals is organic, ... orders of animals PHYSIOLOGY treats of the functions, or uses of the organs of animals and plants Another definition is, “the science of life.” This is also divided into Vegetable and Animal...

Ngày tải lên: 15/03/2014, 13:20

... genetic, hormonal, environmental, sociobiological and physiological factors Over the past few decades, while the risk of developing breast cancer has increased in both industrialized and developing ... are under way One randomized trial compared screening by clinical breast examination and annual mammography together with clinical breast examination alone No benefit from the detection of small ... analysis added into the image, thereby assisting the radiologist in detecting suspect lesions Computer-aided detection has been assessed in several studies, which suggest an incremental value in...

Ngày tải lên: 28/03/2014, 23:20