using lab on a chip technologies to understand cellular mechanotransduction

... bio-compatible, disposable, optically transparent and inexpensive [6] Another particular advantage for polymers is that a wide range of fabrication technologies are available to construct polymer-based ... availability of technologies to construct and employ them into functional analytical systems with various detection modes Since the lab- on- a- chip concept has been conceived to be a powerful tool ... interdisciplinary nature of this area, it is crucial to include a diverse range of expertise in both the fabrication and application areas to address issues relating to lab- on- a- chip devices This is one of...

Ngày tải lên: 12/09/2015, 11:29

... Acta Veterinaria Scandinavica 2009, 51:36 Background Files with information on animal disease have a variety of applications at both the herd and national level, including monitoring the ... potential errors (bias and random error) related to data based on clinical examina- Page of 10 (page number not for citation purposes) Acta Veterinaria Scandinavica 2009, 51:36 http://www.actavetscand.com/content/51/1/36 ... elaborate on that specific situation?' Data Analysis The qualitative analysis is based on a phenomenographic approach; that is a qualitative method to use empiric data (e.g., interview) to describe...

Ngày tải lên: 25/10/2012, 10:45

... prevalence rate Analytic method Two approaches were used for analysis: data mining using classification and regression trees (CART) and standard statistical analyses using ordinary least squares ... professional advancement [3] There is widespread recognition that the factors associated with health are multifactorial and include not only health-related risk factors but also social determinants ... expenditures on health, both physician and nurse density make a contribution to HIV/ Discussion This paper describes how a data mining approach and standard statistical analyses were able to support...

Ngày tải lên: 18/06/2014, 17:20

... EURASIP Journal on Wireless Communications and Networking MEASUREMENTS AND DATA ANALYSIS The building penetration loss and the delay spread were measured as a function of elevation angle and ... of concrete layer, thermal isolation, and roofing Gate area is separated by glass walls Windows are made of two-layer silver coated glass Aluminium lamellas are placed in front of the windows as ... IEEE Transactions on Antennas and Propagation, vol 41, no 7, pp 954–961, 1993 [9] C Oestges and A J Paulraj, “Propagation into buildings for broad-band wireless access,” IEEE Transactions on Vehicular...

Ngày tải lên: 21/06/2014, 23:20

... digital -to- analog and analog -to- digital converters, as well as phase-locked loops are designed at least partially at the transistor level Virtually all other digital designs, however, start out as ... Verification Strategy 11.3 Interface Verification 11.3.1 Transaction Verification 11.3.2 Data or Behavioral Verification 11.3.3 Standardized Interfaces 11.4 Functional Verification 11.5 Random ... restrictions – In particular, valid configurations and parameter values must be documented Any restrictions on configurations or parameter values must be clearly stated Interfacing requirements and...

Ngày tải lên: 28/06/2014, 18:01

... label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array PNAS 2002, 99:9783-9788 15 Laiwattanapaisal W, Yakovleva J, Bengtsson M, Laurell T, Wiyakrutta ... Takata M, Nakashima M, Takehara T, Baba H, Machida K, Akitake Y, Ono K, Hosokawa M, Takahashi M: Detection of amyloid protein in the urine of Alzheimer’s disease patients and healthy individuals ... Caenorhabditis elegans and cell imaging P Natl Acad Sci USA 2008, 105:10670-10675 97 Hatakeyama K, Tanaka T, Sawaguchi M, Iwadate A, Mizutani Y, Sasaki K, Tateishi N, Matsunaga T: Microfluidic device using...

Ngày tải lên: 10/08/2014, 05:21

... results are highly consistent between laboratories and datasets from different laboratories can be shared, leading to construction of standard databases However, the limitations as to the size and ... GC/MS is biased against non-volatile, high-MW metabolites, all metabolites can be analyzed after chemical derivatisation at elevated temperatures prior to analysis Due to hard ionization energies, ... each sample as well as those of replicate data sets using METDAT Data processing and data analysis was also carried out using MATLAB v 7.4.0.287, R200 7a, 2007 (The MathWorks Inc., Natick, MA,USA)...

Ngày tải lên: 11/09/2015, 21:52

... GTTGTAAAACGACGG QD655 (red) ID5 GGAAATGTCTCAGGT QD525 ID6 GAGTCCGAGAAGAAT QD565 ID7 GGTCTATATAAGCAG QD585 ID8 CTTTATGTTTTTGGC QD655 ID9 TGATGATCCCATTGA QD525 ID10 ACATTACCAACTGCT QD565 ID11 CTAGTACACTGTAGT ... software, named LabArray, was developed to control the real-time imaging and analysis of DNA microarrays during dissociation curve studies Microarrays were subjected to a constant temperature gradient ... beads onto microfluidic devices is to etch an array of pyramidal wells on a silicon wafer [19] Each well is used to confine an agarose bead (300 μm) conjugated with a DNA probe Using this bead...

Ngày tải lên: 14/09/2015, 13:07

... EEPROM as a Start or Stop condition FIGURE 3: Bus Activity MCU SDA Line BYTE READ S T A Control Byte/ R Device Address T S1 010 AAA0 MSB Address Byte S T O P Data Byte S 1 A A A1 A C K A C K Bus Activity ... actions: The MCU generates a Start condition on the I2C bus to initiate data transfer • I2EN = 1; //enable I2C part • CRSEL = 0; //select internal baud generator • STA = STO = SI = AA = 0; //clear ... K A C K A C K A C K N A C K DS01113B-page AN1113 INITIALIZATION START DATA TRANSFER Initialization consists of initializing the hardware peripheral within the MCU It performs the following actions:...

Ngày tải lên: 11/01/2016, 16:45

... certification for its worldwide headquarters, design and wafer fabrication facilities in Chandler and Tempe, Arizona; Gresham, Oregon and design centers in California and India The Company’s quality ... DS0123 4A- page 11 AN1234 CONCLUSION This application note offers designers a set of firmware routines to access Microchip’s SPI serial EEPROMs using a hardware peripheral The code demonstrates byte and ... is ready to receive additional commands The WEL bit is also cleared at the end of a write cycle, which serves as additional protection against unwanted writes The firmware remains in a continuous...

Ngày tải lên: 11/01/2016, 17:02

... wonderful treatment My special thanks are due to Mark Walsh, Barbara Lovenvirth, Jessica McBride, Tina Kolb, Bridget Maddalena, Sean Flannagan, and Lynda Fishbourne I am also thankful to Artech’s ... infancy and robust commercial tools for formal specifications are not yet available Today, simulatable specifications are VLSI design Architecture design Optimization area/speed/power Hardware ... implementation method There are two possible ways to develop specifications: formal specifications and simulatable specifications Formal specifications can be used to compare the implementation at various...

Ngày tải lên: 08/03/2016, 11:38

Ngày tải lên: 25/08/2016, 18:58

... to refine the initial values, again preferably using DC and AC data The quasisaturation parameters are likewise obtained by optimization to output curves that show significant quasi-saturation ... have to satisfy the conditions to be computationally economical in addition to being accurate and to scale over various generations of technology Colin McAndrew’s paper addresses bipolar transistors ... modelhave been known for a long time, such as its inability to model collector resistancemodulation (quasi-saturation) and parasitic substrate transistor action And theinexorable advance of IC manufacturing...

Ngày tải lên: 12/10/2016, 13:23

... proliferation, apoptosis, and cell differentiation All these processes are essential to maintain tissue homeostasis Abnormal mechanical loading conditions are observed to alter cellular function, consequently ... secondary messenger pathways and local mediators generated in response to secondary messenger activation are affected in the load transduction of osteoblasts and osteoclasts Various secondary ... Kinase A/ C RA Rheumatoid arthritis RANK Receptor activator of Nf-kB RANKL RANK Ligand TGF Transforming Growth Factor TNF Tumor Necrosis Factor Abbreviation Expansion C Chapter F Figure S Section...

Ngày tải lên: 26/09/2015, 10:44

... initial concentration of MABA-CDP bound to the enzyme, A is its total concentration, and P is the total concentration of human UCK Data were analyzed using kaleidagraph (Abelbeck Software, ALSYD, ... The Authors Journal compilation ê 2007 FEBS D Topalis et al UMP-CMP kinase and acyclic phosphonate analogs Fig Fluorescence assays with MABA-CDP bound to the human UCK acceptor site (A) Dissociation ... contrast to Escherichia coli CMP kinase [17] Mant-ATP was displaced by ATP with a K ATP ẳ 10 lm in a competitive titration and in an D indirect titration assay for several ATP concentrations (not...

Ngày tải lên: 07/03/2014, 09:20

... obligation issuances require voter approval.  12 The County has a AAA general obligation bond rating, but the rating on the bonds is lower because the county pledged its annual appropriation, rather ... reasonable expectation of loan defaults, and program administration costs The first option was not feasible for Saint Louis County because its program administration costs, alone, are higher than ... important to note that this 70/30 limit applies to a state’s entire bond issuance capacity—not any single issuance For example, the State of California has allocated some portions of its QECB capacity...

Ngày tải lên: 22/03/2014, 18:20

... Vesna Savic and Clara Sommarin External: Desiree Abrahams, Chris Avery, Malena Bengtsson, Sara Damber, Aidan Davy, Rachel Davis, Adrienne Gardaz, Halshka Graczyk, John E Grova, Marie Guibreteau, ... Corporation INHOPE International Association of Internet Hotlines ILO International Labour Organization ISO International Organization for Standardization ISP Internet service providers NGO non-governmental ... • Start with scoping from the top, using publicly available information, gathered from international sources, national statistical offices, and national and local research sources to look across...

Ngày tải lên: 23/03/2014, 02:20

... http://www.jiasociety.org/content/12/1/3 Table 1: Univariate analysis of variables associated with viral failure in 496 Ugandans on ART at the Infectious Diseases Institute, Kampala, Uganda Variable Total Undetectable viral load N ... Figure Kampala, Uganda 496 clinical algorithms to monitor for viral failure (VF) in TwoUgandans on ART at the Infectious Diseases Institute in Two clinical algorithms to monitor for viral failure ... cross-sectional study of 496 Ugandans established on NNRTI-based ART We evaluated combinations of adherence, clinical and laboratory variables to determine viral failure Study setting This study was...

Ngày tải lên: 20/06/2014, 08:20

... flexible oxide-metal-oxide [OMO] multilayer electrodes, such as IZO/Ag/IZO, ITO/Ag/ITO, IZTO/Ag/IZTO, GZO/Ag/GZO, AZO/Ag/AZO, NTO/Ag/NTO, and ZTO/Ag/ZTO schemes, have been suggested due to their very ... though a very thin Ag layer (10 nm) was employed in the AIA structure However, deposition of the top IZO layer on the AIA multilayer leads to an increase in the optical transmittance of the AIAI ... the resistance caused by the formation and propagation of cracks in the clamped IAIA region, we employed tilted Cu plates By repeated linear motion of the Cu plates, we were able to flex and curve...

Ngày tải lên: 20/06/2014, 23:20

... multilayer passivation Conclusions SiON/Ag/SiON multilayer passivation prepared by continuous R2R sputtering was investigated as a function of the top and bottom SiON thickness The SiON/Ag/ SiON ... cross-sectional images clearly demonstrate well-defined bottom SiON, Ag, and top SiON layers without interface layers These sharp interfaces indicate that there were no interface reactions and no formation ... cm/s as a function of the SiON target RF power Subsequently, a constant Ag layer was sputtered on the bottom SiON layer using a DC power of 350 W The top SiON layer was sputtered on the Ag layer...

Ngày tải lên: 21/06/2014, 17:20