using 1thinsp029thinsp591 snps from the illumina 1thinspm platform

Statistical methods for the detection and analyses of structural variants in the human genome

Ngày tải lên : 09/09/2015, 10:14

... detected using high-density SNP arrays CNVs/ROHs detected using these technologies are unfortunately limited by the density of the probes, as well as the location of the probes For example, array platforms ... compared to the reference panel There are 30 probes in this region in the platform used, and the length of the region is 27,963 bases Figure 2.4: Figure from Wang et al., 2007, illustrating the unique ... read may span the breakpoint of the CNV SR analysis has the advantage of being able to pinpoint the location of the breakpoints Assembly-based AS methods, on the other hand, not align the reads to...

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Báo cáo khoa học: Structure–activity relation for synthetic phenoxazone drugs Evidence for a direct correlation between DNA binding and pro-apoptotic activity pdf

Ngày tải lên : 31/03/2014, 07:20

... calorimetrically in the temperature range from T1 to the current temperature T The melting curves Q(T) obtained from the heat absorption curves q(T) using eqn are shown in Fig The binding of ligands ... under the curve of heat capacity dependence on temperature, DCp ¼ ƒ(T), and the baseline drawn between the temperatures at the beginning (T1) and the end (T2) of the transition, corresponds to the ... were investigated using the melting curves Q(T), derived from the heat absorption curves DCp(T) using the following relation: HðTÞ ¼ DQðTÞ=DQ0 ð5Þ RT where DQðTÞ ¼ T1 DCp ðTÞ dT is the heat effect...

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Báo cáo y học: "Direct electrochemical analyses of human cytochromes b5 with a mutated heme pocket showed a good correlation between their midpoint and half wave potentials" doc

Ngày tải lên : 10/08/2014, 05:21

... precipitation of the protein in the sample solution Therefore, we did not pursue further on the effects of these cations on the cyclic voltammogram in the present study We, then, measured the cyclic ... the other heme axial ligand The latter is on the side of His68 residue These two residues might be essential for the stabilization of the heme prosthetic group in the hydrophobic heme pocket Therefore, ... near the entrance of the heme-pocket crevice (Figure 1B) Leu51 and Ala59, on the other hand, are located in the bottom of the heme pocket (Figure 1B) The former is on the side of His44 residue, the...

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báo cáo khoa học: " A hypothetical correlation between hyaluronic acid gel and development of cutaneous metaplastic synovial cyst" potx

Ngày tải lên : 11/08/2014, 20:20

... participated in the surgical treatment and in the follow-up of this patient, MT: drafted the manuscript and reviewed the literature, FMA: participated in the surgical treatment and in the follow-up ... possible side effect of the use of hyaluronic acid fillers for increasing the volume of certain regions of the face Consent Statement Written informed consent was obtained from the patient for publication ... Further studies are necessary to determine the underlying mechanism and the causes of this cyst formation Conclusions If confirmed by other colleagues, it might be interesting to consider the...

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Báo cáo y học: "Association between copy number variation of complement component C4 and Graves’ disease" ppsx

Ngày tải lên : 10/08/2014, 10:20

... bacteria, this result may provide another view to support the hypotheses that the pathogenesis of vitiligo may be more relevant to the existence of the immune complex than the pathogen In addition, recent ... (SLE): systemic lupus erythematosus Authors’ contributions YHL designed the study, managed the literature searches, undertook the statistical analysis, and wrote the draft of the manuscript LW designed ... were estimated from logistic regression models adjusting for age, nodular hyperplasia, myxedema and GO with GD which might aid in the diagnosis of the disease and the development of therapeutic...

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báo cáo khoa học: " Ethical issues raised by common copy number variants and single nucleotide polymorphisms of certain and uncertain significance in general medical practice" potx

Ngày tải lên : 11/08/2014, 12:20

... penetrance, and the CNV may be the cause of the phenotype in the child What should the laboratory report to the physician and what should the physician tell the family? Should the information ... rise to the same phenotype (for example, neurofibromatosis, OMIM-162200), generally the ethical issues surrounding CNVs are very different from those related to SNPs Much of the knowledge of the ... that the IQ of such apparently unaffected individuals with the deletion was statistically significantly lower than for their non-deletion siblings, but the majority of the IQs are still within the...

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A Contrastive Analysis between the Verb ‘Run’ in English and the Verb ‘Chạy’ in Vietnamese

Ngày tải lên : 06/04/2013, 08:43

... English, the verb tense shows the time of the action or state; the aspect of a verb defines the temporal flow (or lack thereof) in the described event or state In English, for example, the past-tense ... escape from his look I ran into the garden (6:36) - The veins in his forehead stood out, the tears ran from his eyes, (6:155) 2.1.1.2.1 General Meanings Together with the development of the Information ... that the study can help the translators when working with the verbs ‘run’ and ‘chạy’ in their general meanings, their idioms, their synonyms and other microlinguistic factors that effect the uses...

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Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt

Ngày tải lên : 18/02/2014, 06:20

... is present for the last four residues at the C-terminus The stereochemistry of the model has been assessed using the program procheck [23] Ninety per cent of the residues fall in the most favoured ... model building using the program o [42] Approximately 7% of the randomly chosen reﬂections were excluded from reﬁnement of the structure and used for the free R-factor calculation [43] The program ... centre and the ligand binding site The hACMSD active site is located in a crevice on the protein surface at the C-terminal opening of the b-barrel (Fig 2), with a Zn2+ ion occupying the metal...

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Báo cáo khoa học: Interaction between Lim15/Dmc1 and the homologue of the large subunit of CAF-1 – a molecular link between recombination and chromatin assembly during meiosis pot

Ngày tải lên : 07/03/2014, 05:20

... nuclei from the premeiotic S phase until the pachytene stage, and then disappeared at metaphase I (Fig 2C) Consistent with our previous observations [16,17], CcLim15 localized within nuclei from the ... results from other organisms [27,33], CcCac1L-N speciﬁcally bound to CcPCNA (Fig 3C), conﬁrming the evolutionarily conserved CAF-1–PCNA complex From these results, we suggest a novel role of the ... Several DNA synthesis events take place during the meiotic prophase, even after genome-wide replication at the premeiotic S phase [32,34] In the current model, DNA synthesis is required in the molecular...

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Báo cáo khoa học: "Augmented Dependency Grammer: A Simple Interface between the Grammer Rule and the Knowledge" pptx

Ngày tải lên : 09/03/2014, 01:20

... If the focused word (called FOCUS) and the word on the top of the push-down stack (called Pd-TOP) have the FEATUREs specified by the rule, a new HEAD with the derived FEATUREs is created by the ... head, the true semantic head of w3 can be found among the words (wl and w2) syntactically dependent on the word, w3 That is the word, wl Furthermore, the crossing of a2 and a3 violates the non-crossing ... refers to the context in the context stack if needed, and then constructs the semantic dependency if the word which has a semantic dependency relation to the word stored within a context in the context...

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Báo cáo khoa học: Correlation between conformational stability of the ternary enzyme–substrate complex and domain closure of 3-phosphoglycerate kinase potx

Ngày tải lên : 16/03/2014, 18:20

... substrate to one of the two domains can also stabilize the structure of the other domain [32–34] Often the results of studies with the solubilized PGK not support the suggestion from the X-ray crystallographic ... cooperativity upon substrate binding in the mutants Another thermal unfolding study of a substrate-free PGK from the thermophilic bacterium Thermotoga maritima has led to the proposal of a four-state model ... not the clariﬁcation of the overall mechanism of thermal unfolding We have restricted ourselves to the question of whether unfolding of the two domains is (even slightly) separated Therefore, thermal...

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HOW TO BRIDGE THE DISTANCE BETWEEN BUSINESS STRATEGY AND DESIGN.A VISUAL PRESENTATION BY MARTY potx

Ngày tải lên : 22/03/2014, 14:20

... companies, STRATEGY is separated from CREATIVITY by a wide gap On one side of the gap are STRATEGIC THINKERS ANALYTICAL LOGICAL LINEAR NUMERICAL VERBAL On the other side are CREATIVE THINKERS ... ORBITZ ON SUNDAYS THEY WORSHIP HARLEY, GOD OF THE OPEN ROAD The three most important words in differentiating your brand: FOCUS FOCUS FOCUS IS THIS HOW YOUR CUSTOMERS SEE YOU? THE FOCUS TEST: ... BILLION WITHOUT THE BRAND, COKE’S GLASS WOULD BE HALF EMPTY COKE’S MARKET CAP, NOT INCLUDING BRAND VALUE: $50 BILLION PREDICTION BRAND WILL BECOME THE MOST POWERFUL STRATEGIC TOOL SINCE THE SPREADSHEET...

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Báo cáo khoa học: A dimer of the FeS cluster biosynthesis protein IscA from cyanobacteria binds a [2Fe2S] cluster between two protomers and transfers it to [2Fe2S] and [4Fe4S] apo proteins ppt

Ngày tải lên : 31/03/2014, 01:20

... 25 °C in the presence oxygen absorption spectra were recorded from both samples The spectrum of the control sample without ferredoxin was subtracted from the spectrum of the sample were the FeS ... of the cysteine side chains provided by one IscA protomer In a subsequent step the two cysteine side chains from the other IscA protomer might then be replaced by cysteine side chains from the ... otherwise Analysis of the transfer reaction was made by nondenaturing PAGE using 20% polyacrylamide gels FeS cluster transfer from IscA1 to APS reductase apo protein from Catharanthus roseus The...

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Báo cáo khoa học: Insights into the design of a hybrid system between Anabaena ferredoxin-NADP+ reductase and bovine adrenodoxin pot

Ngày tải lên : 31/03/2014, 07:20

... systems Therefore, it is feasible to consider using proteins to work in ET chains for which they were not naturally synthesized In the present study we have tried to increase the knowledge of the ... is interesting to point out the different arrangement of the [2Fe)2S] centres of these Fds The cyanobacterial Fd presents an increased shielding from the solvent of the active Fe in ET when compared ... represents the initial rate of the reaction, vs the Adx concentration shows an almost linear correlation (Fig 3A), suggesting that the formation of the optimal complex between the two proteins limits the...

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báo cáo hóa học: " Evaluation of adaptation to visually induced motion sickness based on the maximum cross-correlation between pulse transmission time and heart rate" docx

Ngày tải lên : 19/06/2014, 10:20

... position from the screen and at the same time of each day The experimental protocol was approved by the University's Internal Review Board and informed consent was obtained from all subjects before the ... transmission time (PTT) was defined as the time interval from the peak of the ECG, R-wave, to the point at which the plethysmogram signal begins to rise The value of PTT is related to blood pressure, ... derived from the repetitive exposure to the same swaying video image On the other hand, TS of the subjects on Day were higher than on Day such as Subject-2 who belonged to TS-up group The changes...

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Báo cáo hóa học: " The correlation between radiative surface defect states and high color rendering index from ZnO nanotubes" docx

Ngày tải lên : 21/06/2014, 00:20

... discussed above by the UV emission and the re-absorbance in the ZnO The defect-related emission can be further enhanced by the recombination process in the nanotubes, when the device is biased ... nanotubes The main features of the spectra illustrate firstly the UV emission intensity, which is generally ascribed as originated from band edge of ZnO, from the nanotubes is much higher than the ... with the inner surface of the nanotube Secondly, the enhanced emission intensity in the visible range can be attributed to the higher concentration of surface defect states on the walls of the...

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Báo cáo sinh học: "A balancing act between the X chromosome and the autosomes" ppsx

Ngày tải lên : 06/08/2014, 18:21

... [11] Perhaps the most important finding of Gupta et al [8] is the fact that the X chromosomes in the Drosophila germline are upregulated to match the expression of the autosomes The molecular ... modulate the expression of the X chromosome in the soma and germ cells Further studies to elucidate how each species achieves dosage compensation between the X chromosomes and the autosomes in the ... soma centered on These findings confirm that, in Drosophila somatic tissues, there is a doubling of transcription from the single male X chromosome In the germline, however, the findings of Gupta...

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Báo cáo y học: " A rigid barrier between the heart and sternum protects the heart and lungs against rupture during negative pressure wound therapy" doc

Ngày tải lên : 10/08/2014, 09:21

... however, the effect of the tissues deeper in the wound, such as the heart and lungs in the sternotomy wound, have been less well studied In one of our previous studies using MRI it was shown that the ... also drawn towards the vacuum [11] This caused the right ventricle to bulge into the space between the sternal edges, and these sharp edges protruded into the anterior surface of the heart [11] This ... underlying the injury to organs exposed to NPWT [11] Inserting a rigid barrier between the heart and the sternum prevents the heart from being drawn up and deformed by the sternal edges [11] To the...

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Báo cáo y học: "a diagnostic dilemma between psychosis and post-traumatic stress disorder: a case report and review of the literature" ppsx

Ngày tải lên : 11/08/2014, 00:22

... designed the study, reviewed the existing literature and drafted the manuscript PP carried out the follow up on the patient, took part in the scientific discussion and helped to draft the manuscript ... significant improvement of their PTSD symptoms and high treatment satisfaction [25] Besides the psychopharmacological therapy, our patient could benefit from one of these psychotherapeutic programs ... with these issues, as well as preventing a relapse We reviewed the scientific literature regarding the diagnosis and treatment of PTSD with psychotic symptoms There are few case reports about the...

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