ubiquitin proteasome system in cancer

... decreased in the tumour itself but also in the resection margins obtained at a late stage in tumour development It should be noted that in all cases the resection margins were assessed by routine clinical ... coincide with a margins obtained were all classified as normal by routine protein cross-reacting with an antibody directed against a 69 clinical and histological methods Histochemical or amino-acid ... colorectal carcinoma (Table 2) Interestingly, the level of Neu5,9Ac2 in the resection margin obtained from two Stage IV patients was dramatically reduced in comparison with that observed in Stage I,...

Ngày tải lên: 07/03/2014, 14:20

... intramolecular disulfide bonds [5] In the transgenic lines, fhx/P25 molecules of 30 and 27 kDa were both reactive to biotinylated ConA indicating that N-linked oligosaccharide chains existed in ... glycoprotein [28,29], in uenza virus hemagglutinin [30,31], and IgM [32] in ER, a further role of N-linked oligosacharide chains of fhx/P25 in the process of assembly of the elementary unit in ER ... fhx/P25 contains terminal a1,2-mannose residues in their N-linked oligosaccharide chains, whereas such mannose residues are absent in the 27-kDa fhx/P25 The N-linked oligosaccharide chains were suggested...

Ngày tải lên: 16/03/2014, 16:20

... Examination of the N-glycan structures provides insight into the processing of sugar chains in molluscs (Fig 5) In this context, the question of whether the unique N-glycan structures of rhodopsin ... chain from reorienting within the translocon It is also possible that difucosylation of the innermost GlcNAc affects rhodopsin function by a local conformational change in the polypeptide chain ... Preparation of pyridylaminated N-glycans from squid rhodopsin and characterization by 2D mapping Rhodopsin protein (1 mg), corresponding to 20 nmol oligosaccharides, was used as the starting material All...

Ngày tải lên: 23/03/2014, 17:22

... 60 min, samples were withdrawn, diluted in buffer Hydrogen bonds involving Gly372 in factor VIIa containing mgặml)1 bovine serum albumin, and the residual amidolytic activity was measured using ... strongly in favour of the former, can be identied by gain-ofactivity mutations Site-directed mutagenesis at certain positions in FVIIa has indeed resulted in molecules with increased intrinsic activity, ... loop is one of the regions that is inuenced by sTF binding [25] Subsequent work, including molecular dynamics simulations, pinpointed in particular the C-terminal part of activation loop [26]...

Ngày tải lên: 18/02/2014, 08:20

... polyamines (putrescine, spermidine and spermine) through conversion of l-arginine into l-ornithine [16] The latter is in turn used by ODC to produce putrescine, the precursor of spermidine and ... ArgI in the context of virus infection was also analyzed No increase in ArgI mRNA (Fig 4A) or protein levels (Fig 4B) was observed in Jurkat cells in response to SeV infection ArgII is involved in ... tetracycline inducible cell line, rtTAIRF-3 5D-Jurkat, with doxycycline for 36 h, in the presence of neutralizing antibodies against IFNs [14] ArgII mRNA was strongly induced in IRF-3 5Dexpressing...

Ngày tải lên: 07/03/2014, 21:20

... functioning of the kidney, maintaining the glomerular basement membrane architecture is crucial, which in turn depends on the proper structure and function of matrix proteins, including laminin and ... studying the structure of oligosaccharides is crucial in ascertaining their role The total carbohydrate content in laminin was shown to be  32% Reports of the abundance of carbohydrates in laminin ... summarized in Table In this investigation, diabetes results in changes in the oligosaccharides of laminin In addition, dietary fiber and butyric acid were also able to bring about subtle changes in oligosaccharide...

Ngày tải lên: 22/03/2014, 17:20

... checked the presence of a vaginal plug in the next morning, denoted as gestation day 0.5 (GD 0.5) The plug-positive females were maintained in a vinyl isolator established in the hazard room to prevent ... 3) The dose-increase to 20 µg/kg bw TCDD-induced cleft palate in ddY mice 117 Table Fetal mortality and incidence of cleft palate in C57BL/6 mice following oral treatment of TCDD during pregnancy ... TCDD-induced cleft palate was opposite to that of them to PCTs-induced cleft palate, indicating that the mechanism to induce cleft palate may be different between TCDD and PCTs In addition, the increase...

Ngày tải lên: 07/08/2014, 14:23

... Switch_B#show spanning-tree brief 3-4 CCNA 3: Switching Basics and Intermediate Routing v 3.0 - Lab 7.2.6 Copyright  2003, Cisco Systems, Inc c What changes have taken place in the command output? ... first 12 interfaces and ports of each switch Switch A Port # Switch B 10 11 12 2-4 CCNA 3: Switching Basics and Intermediate Routing v 3.0 - Lab 7.2.6 Copyright  2003, Cisco Systems, Inc Step ... typing exit, and turn all the devices off Then remove and store the cables and adapter 4-4 CCNA 3: Switching Basics and Intermediate Routing v 3.0 - Lab 7.2.6 Copyright  2003, Cisco Systems, Inc...

Ngày tải lên: 11/12/2013, 14:15

... determine whether these adjacent ARE sites played a role in protein binding activity Initial experiments confirmed that the extended wild-type ARE sequence provided specific protein binding sites ... cooperate in modulating PAI-2 mRNA stability, REMSA analyses were performed to determine the role of the ARE II and ARE IV sites in the binding of proteins to the ‘extended ARE’ Binding of cytoplasmic ... A (1998) The serine proteinase inhibitor (serpin) plasminogen activation inhibitor type protects against viral cytopathic effects by constitutive interferon alpha ⁄ beta priming J Exp Med 187,...

Ngày tải lên: 16/02/2014, 09:20

... bisphosphatase domain than in the kinase domain Conservation in the bisphosphatase domain is in the range 26–40% compared with just 13–28% in the kinase domain The corresponding figures for the intertrypanosomatid ... ankyrin-motif repeats in Tb1, Lm1, Tc1–1, Tb2, Lm2 and Tc2–1 PFK-2 and FBPase-2 domains in the C-terminal halves of the proteins are indicated as in Fig In the N-terminal halves, the ankyrin motifs ... residues involved in substrate binding (boxed in Fig 3) based mainly on X-ray crystal structures The binding of ATP analogues in the PFK-2 active site and of fructose 6-phosphate and inorganic...

Ngày tải lên: 16/03/2014, 22:20

... www.it-ebooks.info Beginning Python® Using Python 2.6 and Python 3.1 James Payne Wiley Publishing, Inc www.it-ebooks.info Beginning Python®: Using Python 2.6 and Python 3.1 Published by Wiley Publishing, Inc ... Integrating Java with Python Scripting within Java Applications Comparing Python Implementations Installing Jython Running Jython Running Jython Interactively Running Jython Scripts Controlling ... Programming Creating Classes Extending Existing Classes Finishing Your Modules 162 163 163 163 165 166 Defining Module-Specific Errors Choosing What to Export Documenting Your Modules Testing Your...

Ngày tải lên: 24/03/2014, 01:21

... metalloproteinases (MMPs) constitute a large family of proteolytic enzymes containing a metal in their organic structure playing key roles in degradation of proteins in extracellular matrix and in tissue ... the main common pathologic finding in these disorders Clinical studies have investigated the role of MMP-1 in this pathologic process [6,14,15] These studies evaluated the levels of MMP-1 in the ... mechanism involves a metal ion such as zinc (Zn2+) and calcium (Ca2+) [10] Metalloproteinases, also called matrixins, include a large family of proteolytic enzymes, known as metzincin super-family...

Ngày tải lên: 10/08/2014, 10:20

... epithelial cells infected by human rhinovirus [17] were also shown to induce increased expression level of VEGF, implicating their roles in mediating immu- Severity of plasma leakage in DENV patients ... production levels comparing between DENV-infected and mock-infected HPMEC-ST1.6R endothelial cells Time (Hrs) Post-infection DENV-1 -infected DENV-2 -infected DENV-3 -infected DENV-4 -infected 0.542504 ... 0.018874 Competing interests The authors declare that they have no competing interests Authors' contributions AA designed the experiments, trained students in experimental protocols, maintained cell...

Ngày tải lên: 12/08/2014, 04:21

... dẫn học sinh đọc tác t©m hån cđa nhµ th¬ b¹n mÊt phẩm, gọi học sinh đọc tác III Đọc- hiểu : phẩm 1.Hai câu đầu :Cảm xúc tác giả: - “BácDương …thôi rồi”:tác giả bàng hoàng nghe tin Học sinh tìm ... thiếu vắng qn đội qui -> đứng lên đánh giặc hi sinh oanh liệt Hình tượng nghĩa sĩ thể tinh thần tự giác cao độ, anh dũng vơ song làm cho kẻ địch kinh hồn, bạt vía Ai v·n: - §©y lµ tiÕng khãc lín ... theo motif có sẵn kinh nghiệm cá nhân - Ít dựa vào kinh nghiệm cá nhân nên người kể chuyện thường người biết trước, biết hết 5.Dặn dò: Soạn Luyện tập tượng tách từ 6.Rút kinh nghiệm- bổ sung:...

Ngày tải lên: 10/06/2013, 01:25

... She is a student c.What is her brother’s name ? His name’s Minh d.How old is he ? He is twenty e.Where does Thuy live ? She lives in a house ( near a lake ) f.What’s there , near the house ... paddy near her house Complete the sentences : IV Completing : V Further practice : 1.Talk about Thuy’s house : This is Thuy’s house It is in the country Near her house , there is a lake , a ……… ... 1 places classes routine sports Let’s play the game :” Pelmanism “  Thursday , November 22nd , 2007 Period 32 Unit :...

Ngày tải lên: 22/06/2013, 01:25

... Câu2: (4đ) Kinh tế: -Phát triển chậm ,tụt xuống thứ giới sản xất công nghiệp - Một số ngành công nghiệp đời tăng trởng nhanh : đIện khí, hoá chất - Các công ty độc quyền đời chi phối kinh tế Pháp ... c, Thứ d, thứ 2, Vì nói Mỹ xứ sở ông vua công nghiệp a, Mỹ có công nghiệp phát triển b, Mỹ có kinh tế phát triển c, Mỹ có công nghiệp phát triển mạnh mẽ công ty độc quyền khổng lồ hình thành ... bảo vệ quyền lợi cho B, Đẩy mạnh sách hàng đầu giới cầm quyền Anh Câu (1 điểm): Hãy nối thông tin cột A cho phù hợp với cột B A B a Anh 1, Chủ nghĩa đế quốc thực dân b Pháp 2, Chủ nghĩa đế quốc...

Ngày tải lên: 30/06/2013, 01:28

... kinh tế , pháp luật trò, pháp luật đạo đức theo quan điểm triết học Mác-Lênin Chế độ kinh tế sở pháp luật; trò biểu tập trung kinh tế , , đường lối trò giai cấp cầm quyền trước hết thể sách kinh ... quan hệ kinh tế có nội dung pháp luật Pháp luật luôn phản ánh trình độ phát triển kinh tế, cao thấp không khác với trình độ phát triển kinh tế Ví dụ: kinh tế thò trường, quan hệ chủ thể kinh tế ... hệ pháp luật với kinh tế thể chỗ, sinh từ điều kiện, tiền đề kinh tế pháp luật không phản ánh cách thụ động mà có tác động trở lại phát triển kinh tế Pháp luật tác động đến kinh tế theo hướng...

Ngày tải lên: 09/07/2013, 01:25

Ngày tải lên: 26/07/2013, 01:25

Ngày tải lên: 04/09/2013, 12:10