treatment of triple negative breast cancer

... G-CSF support in triple- negative large operable breast cancer Ann Oncol 2009, 20:1185-1192 62 Isakoff SJ: Triple- negative breast cancer: role of specific chemotherapy agents Cancer J 2010, 16:53-61 ... heterogeneity of TNBC, Doane and colleagues [109] conducted a genome wide gene expression profiling study of 99 patients with breast cancer, 41 of whom had triple negative disease They noticed that nine of ... expression of several of the kinases of interest and established that of the 20 kinases evaluated, 14 were critical for the growth of ER -negative breast cancer cell lines The majority of these...

Ngày tải lên: 10/08/2014, 22:21

... THF Tetrahydrofuran TNBC Triple negative breast cancer UV Ultraviolet VEGF Vascular endothelial growth factor ix! INTRODUCTION 1.1 Triple Negative Breast Cancer Triple negative breast cancer (TNBC) ... (2011) Triple- negative breast cancer: an unmet medical need The Oncologist, 16 Suppl 1(suppl 1), 1–11 doi:10.1634/theoncologist.2011-S1-01 Isakoff, S (2010) Triple Negative Breast Cancer: Role of ... selected as the taxane of choice in this study due to its higher efficacy in breast cancer models, which would have more impact in the field of triple negative breast cancer Treatment combining...

Ngày tải lên: 01/10/2015, 17:28

... conservatively managed triple negative early-stage breast cancer J Clin Oncol 2006, 24(36):5652-5657 11 Oakman C, Viale G, Di Leo A: Management of triple negative breast cancer Breast 2010, 19(5):312-21 ... very useful in the treatment of triple- negative breast cancer that is not eligible for hormone therapy or immunotherapy targeting Her2/neu TNBC accounts for 10% to 17% of all breast carcinomas ... targeting CD138 is relevant for the treatment of triple- negative breast cancer and could be applied to patients who relapse after a first-line treatment The possibility of visualizing tumors by immuno-PET...

Ngày tải lên: 21/06/2014, 01:20

... results of a clinical trial to evaluate the performance and safety of XB in the outpatient treatment of early-stage breast cancer patients were recently presented at the American Society of Clinical ... methods of balloon-based APBI are also being explored A modified form of balloon-based brachytherapy called Xoft Axxent Electronic Brachytherapy™ (XB) received FDA clearance for the treatment of breast ... treatment of breast and endometrial cancer The mobile nature of the XB controller, as well as, the limited shielding requirements make XB a logical modality to be utilized for IORT in the treatment of...

Ngày tải lên: 09/08/2014, 04:21

... between coffee consumption and breast cancer risks for ER-positive and ER -negative breast cancers In this study, we examine the association between coffee consumption and postmenopausal breast cancer ... 0.0026 Pb Li et al Breast Cancer Research 2011, 13:R49 http:/ /breast- cancer- research.com/content/13/3/R49 Page of 10 Li et al Breast Cancer Research 2011, 13:R49 http:/ /breast- cancer- research.com/content/13/3/R49 ... each coffee consumption category Hormone replacement therapy Proportion of ever users Family history of breast cancer Proportion with family history of breast cancer Controls (n) in each coffee...

Ngày tải lên: 22/03/2014, 17:20

... studies suggest potentially negative effects of some immune responses in breast cancer Matkowski and Sheu both showed in cohorts of 88 and 24 patients with operable breast cancer, respectively, that ... metastasis of human breast cancer Breast 2008, 17:604-610 10 Kominsky SL, Hobeika AC, Lake FA, Torres BA, Johnson HM: Downregulation of neu/HER-2 by interferon-gamma in prostate cancer cells Cancer ... [13] We performed a pilot study accruing 12 breast cancer patients with HER-2/neu negative tumors (HER-2/neu status: FISH negative) and three breast cancer patients with HER-2/neu positive tumors...

Ngày tải lên: 18/06/2014, 19:20

... studies suggest potentially negative effects of some immune responses in breast cancer Matkowski and Sheu both showed in cohorts of 88 and 24 patients with operable breast cancer, respectively, that ... metastasis of human breast cancer Breast 2008, 17:604-610 10 Kominsky SL, Hobeika AC, Lake FA, Torres BA, Johnson HM: Downregulation of neu/HER-2 by interferon-gamma in prostate cancer cells Cancer ... [13] We performed a pilot study accruing 12 breast cancer patients with HER-2/neu negative tumors (HER-2/neu status: FISH negative) and three breast cancer patients with HER-2/neu positive tumors...

Ngày tải lên: 20/06/2014, 03:20

... hsa-miR-769-5p RE-score profiles of microRNAs for the classification of ER+ and ER- breast tumors Figure RE-score profiles of microRNAs for the classification of ER+ and ER- breast tumors The figure ... expression profiles of miRNAs are informative for the classification of human cancers Based on miRNA-expression profiles, Lu et al [13] reported the classification of 334 leukemia and solid cancers ... positive (ER+) and negative (ER-) breast cancers by examining changes in the expression of the miRNAs' target genes Breast cancer is a common disease, ranking first in terms of annual mortality...

Ngày tải lên: 09/08/2014, 20:20

... Improving the diagnosis and treatment of smearnegative tuberculosis  Part i Improving the diagnosis and treatment of smear -negative tuberculosis Background management of smear -negative pulmonary and ... and initiation of tuberculosis treatment Impact Proportion of pulmonary tuberculosis cases who have died two months into treatment and six months into treatment (or at end of treatment) , stratified ... at the beginning of treatment) ; treatment outcome and date of treatment outcome Identifying, managing and reporting adverse events Adverse events are common during treatment of HIV-associated...

Ngày tải lên: 15/03/2014, 03:20

... importance of the psychological construct of control for women with breast cancer Quality of Life and Breast Cancer 509 Methods Participants The sample consisted of 63 women diagnosed with stage II breast ... a history of stage II breast cancer, currently cancer free, and within two years posttreatment.1 Justification for Stage of Cancer This study focused on women with stage II breast cancer Although ... rate of breast cancer has increased in younger women, issues of femininity arising from the impact of disease on fertility are increasingly important (Oktay, 1998) The experience of breast cancer...

Ngày tải lên: 22/03/2014, 17:20

... Estimation of the performance of classification of breast canEstimation of the performance of classification of breast cancer samples A – The total error rate was plotted against the number of features ... detection of certain less abundant peptides in the presence of albumin [49] Figure between sub-groups of breast cancers patients Estimation of differences of serum proteome patterns Estimation of differences ... possibility of applying SELDI or MALDI mass spectrometric analyses of blood proteome in diagnostics of breast cancer, and elicited serum (or Page of 13 (page number not for citation purposes) Journal of...

Ngày tải lên: 18/06/2014, 15:20

... population of breast cancer survivors Further, QOL of survivors were compared to peers without breast cancer, including matching for place of residence, allowing for more accurate interpretation of meaning ... of Australia; CI: Confidence Interval; EORTC: European Organisation for the Research and Treatment of Cancer; FACT: Functional Assessment of Cancer Therapy; FACT-G: Functional Assessment of Cancer ... American Cancer Society: Breast Cancer Facts Figures 2007-2008 Atlanta: American Cancer Society, Inc 2008 Australian Institute of Health and Welfare (AIHW), Australasian Association of Cancer Registries...

Ngày tải lên: 18/06/2014, 19:20

... impact of exercise training on QOL in breast cancer survivors The aim of this study was to assess the association between physical exercise and quality of life in a population of female breast cancer ... Side effects of adjuvant treatment of breast cancer N Engl J Med 2001 344:1997-2008 26 Zabora J, Brintzenhofeszoc K, Curbow B, et al The prevalence of psychological distress by cancer site Psychooncology ... effects of exercise on QOL for both on -treatment and off -treatment follow-up periods in breast cancer: such evidence is strongly confirmed by our work Reservations could be presented about the use of...

Ngày tải lên: 08/08/2014, 16:23

... disease-specific overall The significance of skin invasion in node negative breast cancer is uncertain Tumors with signs of skin invasion, Table 3: Treatment Case 90 Control Operation Total mastectomy ... regimen which the individual institute determines for node negative breast cancer should be applied to skin invasive node negative breast cancer patients 0.9 0.85 Competing interests 0.8 The author(s) ... by breast cancer was considered Those who died from other causes, as well as the survival cases, were considered censored cases As a control group, we used all node negative invasive breast cancer...

Ngày tải lên: 09/08/2014, 07:21

... Profile also underwent CT scan of the treatment region to assess skin depth A digital photo, illustrating the method of immobilization of the treatment area and a simulation of the set-up of ... http://www.ro-journal.com/content/5/1/87 Page of Figure EBT Treatment of Cutaneous T-cell Lymphoma Photo at pretreatment (left) and at two months of follow up (right) of Ir-192 HDR brachytherapy with surface ... experience of electronic brachytherapy for the treatment of non-melanoma skin cancer Radiation Oncology 2010 5:87 Page of Submit your next manuscript to BioMed Central and take full advantage of: •...

Ngày tải lên: 09/08/2014, 09:20

... versus week of (A) Plot meanstratified by treatment group and pre-treat(A) Plot of mean post-void residual volume versus week of XRT treatment, stratified by treatment group and pre -treatment (baseline) ... the clinical and treatment parameters of the study population, stratified by treatment cohort The mean patient age was 73.9 ± 8.0 years with a mean pre -treatment prostate volume of 53.3 ± 33.5 ... function of weeks of external beam radiation therapy Both cohorts of patients demonstrated a decrease from baseline measurements with the greatest trend seen over the first three weeks of treatment...

Ngày tải lên: 09/08/2014, 10:20

... in the setting of hypofractionated treatment of high-risk prostate cancer Helical tomotherapy will be used as the dynamic intensity modulated radiation therapy solution for both treatment solutions ... R: The potential for sparing of parotids and escalation of biologically effective dose with intensity-modulated radiation treatments of head and neck cancers: A treatment design study Int J Radiat ... in 2006 and approximately 4200 will die of this disease [1] Standard curative treatment for high-risk prostate cancer [2] is a radical course of radiation treatment with long-term androgen suppression...

Ngày tải lên: 09/08/2014, 10:21

... capacity of breast cancer cells 60 3.4.2 Telomere shortening in breast cancer cells at weeks of TQ treatment 62 3.4.3 Prolonged exposure to TQ alters hTERT and TRF2 expression levels in breast cancer ... at telomeric regions in breast cancer cells 66 3.6 Gene expression profiles of normal and breast cancer cells 68 3.6.1 Differential gene expression profiles in breast cancer cells 68 CHAPTER ... instability in cancer 17 1.7 Trends in breast cancer 19 1.7.1 Current treatment for breast cancer 20 1.8 Possible development of telomerase inhibition in cancer therapeutics...

Ngày tải lên: 30/09/2015, 13:41