the development of tamoxifen for breast cancer therapy

... side effects [22]. One of the reasons could be ascribed to the composition of the formulation and the poor control of the drug release rate. Therefore, the development of compatible polymer-based ... L: The role of taxanes in the treatment of breast cancer. Semin Oncol 1996, 23:68-75. [4] Rowinsky EK: The development and clinical utility of the taxane class of antimicrotubule chemotherapy ... participated in the design of the study and coordination of the work as lead investigator. All authors contributed to the interpretation of the results and the drafting of the manuscript, and they read...

Ngày tải lên: 18/06/2014, 22:20

Ngày tải lên: 09/08/2014, 04:21

... in the development of oral can- cer [28], esophageal cancer [29] and colorectal cancer [30]. Furthermore the association between the presence of HPV 16 and the development of head and neck cancer has ... to neurogenesis. The list of these genes is reported in addi- tional file 2. These results support the hypothesis of a possible role of E6 and E7 in the induction of neuroen- docrine differentiation of SCLC. ... and specificity for HPVs identification [32]. The reasons for having false-negative detection of HPVs are the use of inappropriate primers or loss of the HPV L1 and E2 genes during integration. The aim of...

Ngày tải lên: 18/06/2014, 16:20

Ngày tải lên: 11/08/2014, 00:23

Ngày tải lên: 13/08/2014, 23:20

Ngày tải lên: 09/08/2014, 03:22

Ngày tải lên: 09/08/2014, 02:21

Ngày tải lên: 09/08/2014, 04:21

Ngày tải lên: 09/08/2014, 08:23

Ngày tải lên: 11/08/2014, 12:20

Ngày tải lên: 25/07/2013, 11:20

Ngày tải lên: 05/09/2013, 14:19

... for breast cancer in the United States is often multimodal, requiring a combination of therapies including surgery, chemotherapy, hormonal therapy, and radiation. The contemporary view of breast ... Family history of breast and ovarian cancer are strong risk determinants however, with the number of relatives, closeness of the degree of relationships, and ages of diagnosis of affected family ... individual risks for breast cancer 60-85% and may be identified in 5-10% of all breast cancer cases. 28 Personal history of noninvasive breast cancer or previous abnormal breast biopsy containing...

Ngày tải lên: 14/02/2014, 21:20

... 'all the present of earth vanished into the future of Heaven, and the Kingdom of the Infinite arose upon the ruins of the finite.' The beauty of earth was looked upon as an enchantment of the ... attitude of the Fathers of the Church, Basil and Gregory, or for Augustine's deep faith and devout admiration of the works of creation: even the tone of Ausonius and Fortunatus, in their charming descriptions ... you of the sweet exhalations from the earth or the breezes from the river? Other persons might admire the multitude of the flowers, or of the lyric birds, but I have no time to attend to them....

Ngày tải lên: 21/02/2014, 20:20

... (either for the company or for the customer). It includes all activities from the development of an idea or a concept for a product, to the realization of the product during the production stage ... feedback, the purpose of the conceptual model, some background of the research that lead to the development of the model, and key 11852 Afr. J. Bus. Manage. Figure 5. Trend of project ... development New product development (NPD) is a business process for developing new products for a company, whether it is an upgrade of an existing product or a new concept (either for the...

Ngày tải lên: 07/03/2014, 00:20

... cover the entire world of knowl- edge. as generic resource (see figure 2). Before starting the development, the set of field labels relevant for the application must be identified. Then the ... requirement. Unfortunately one of the cur- rent trends in IE is the progressive reduction of the size of training corpora: e.g., from the 1,000 texts of the MUC-5 (MUC-5, 1993) to the 100 texts in MUC-6 ... those. The presence of all the relevant terms should guarantee that the information in the text is never lost; inserting just the relevant terms allows to limit the development effort, and...

Ngày tải lên: 08/03/2014, 21:20

... called CHEMFET of BIOFET. In all of these devices, the surface poten- tial developed at the surface of the semiconductor is based on the direct interaction of the ligand with the exposed atoms of the semiconductor, ... maturation with the commercialization of these pH sensors in the mid-80’s, while they were the platform for the development of other ion-selective FETs and bio-FETs up to date. When SiO 2 , or other metal ... used for the oxidation of ferrocyanide, or the reduction of methyl viologen, and the simultaneous spec- troscopic monitoring of the products through the disc. In the same year, the construction of...

Ngày tải lên: 20/03/2014, 13:05

... whole conversation or for the most part of it). These two knowledges inform the rest of the modules about the situation of the conversation and which one is the goal expressed by the user. Then, the Dialogue ... of the Kernel. The Linguistic Kernel contains the independent knowledge of the system, related to the dialogue management. The rest of the configurable modules are adjusted to the design of the ... allows the user to change the topic of the conversation at any particular moment of the dialogue as well as moving from one service to another just by asking to do so in a colloquial way. Therefore,...

Ngày tải lên: 24/03/2014, 03:20