transforming growth factorβ superfamily

... signaling during transforming growth factor- beta-induced smooth muscle differentiation. J Biol Chem 281, 1765–1770. 143 Deaton RA, Su C, Valencia TG & Grant SR (2005) Transforming growth factor-beta1-induced ... localization of transforming growth factor- beta in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 5, 155–162. 153 Broekelmann TJ, Limper AH, Colby TV & McDonald JA (1991) Transforming growth ... essential for transforming growth factor-beta- mediated stress fiber formation. J Biol Chem 276, 15362–15368. 159 Engel ME, Datta PK & Moses HL (1998) RhoB is stabilized by transforming growth factor...

Ngày tải lên: 07/03/2014, 01:20

... anti-inflammatory cytokine transforming growth factor-b1 (TGF-b1) of the proinflammatory cytokine TNF-a via the induction of FXR1 is the focus of this article. TGF-b1, a member of the large transforming growth factor-b ... post- transcriptional suppression of lipopolysaccharide-induced tumour necrosis factor-a production by transforming growth factor-b1 Tarnjit K. Khera 1 , Andrew D. Dick 1,2 and Lindsay B. Nicholson 1,2 1 Department ... these is Fragile X mental retardation-related protein 1 (FXR1). The anti-inflammatory cytokine transforming growth factor-b1 (TGF-b1), which is involved in the homeostatic regulation of TNF-a, causes...

Ngày tải lên: 22/03/2014, 21:21

... arylhydrocarbon receptor expression by transforming growth factor-b 1 . Mol. Pharmacol. 59, 716 724. 22. Do ă hr, O. & Abel, J. (1997) Transforming growth factor-beta 1 coregulates mRNA expression ... 491]. Nature 394, 909–913. 28. Roberts, A.B. & Sporn, M.B. (1990) The transforming growth factor-bs. In Peptide Growth Factors and Their Receptors I (Sporn, M.B. & Roberts, A.B., eds), ... D. (1999) Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-b activated cells. Cytokine Growth Factor Rev. 10, 187– 199. 34. Xu, W., Angelis, K., Danielpour,...

Ngày tải lên: 31/03/2014, 23:20

... 142: Transforming Growth Factor- ` Protocols Edited by: P. H. Howe â Humana Press Inc., Totowa, NJ Detection of TGF-` in Body Fluids and Tissues Andrew H. Limper Introduction Transforming growth ... to platelet type ` transforming growth factor. Science 226, 705–707. 41. Kojima, S. and Rifkin, D. B. (1993) Mechanism of retinoid-induced activation of latent transforming growth factor-` in ... the cellular receptor for transforming growth factor type `. Biochemistry 25, 3083–3091. 3. Massagué, J. (1987) Identification of receptors for type-` transforming growth factor. Methods Enzymol....

Ngày tải lên: 11/04/2014, 07:14

... diagnosis. Measurements: Serum concentrations of transforming growth factor-beta1 and ferritin. Results: High concentrations of transforming growth factor-beta1 were noticed in patients suffering ... non-alcoholic steatohepatitis; ALT, alanine aminotransferase; CRP, C reactive protein; TGF-β1, transforming growth factor beta1; BMI, body mass index; HOMA, homeostasis model assessment-insulin resistance ... purposes) Journal of Translational Medicine Open Access Research Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign? Giovanni Tarantino* 1 ,...

Ngày tải lên: 18/06/2014, 15:20

... mice overexpressing transforming growth factor-beta 1. Am J Pathol 1995, 147:53-67. 4. Wyss-Coray T, Lin C, Sanan DA, Mucke L, Masliah E: Chronic over- production of transforming growth factor-beta1 ... 25:611-616. 44. Wyss-Coray T, Lin C, Sanan DA, Mucke L, Masliah E: Chronic over- production of transforming growth factor beta-1 by astro- cytes promotes Alzheimer's disease-like microvascular degeneration ... http://www.jneuroinflammation.com/content/1/1/11 Page 2 of 17 (page number not for citation purposes) Background Transforming growth factor-β1 (TGF-β1) is a multifunc- tional cytokine implicated in developmental processes, immune...

Ngày tải lên: 19/06/2014, 22:20

... clinical applications of transforming growth factor-beta (TGF-beta). Growth Factors 1993, 8:1-9. 3. Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB: Transforming growth factor-beta in human ... sequence analysis of simian transforming growth factor-beta cDNA. DNA 1987, 6:239-244. 5. Miller DA, Pelton RW, Derynck R, Moses HL: Transforming growth factor-beta. A family of growth regulatory peptides. Ann ... Transforming growth factor-beta. Mul- tiple actions and potential clinical applications. JAMA 1989, 262:938-941. 7. Beck SL, Chen TL, Mikalauski P, Ammann AJ: Recombinant human transforming growth...

Ngày tải lên: 09/08/2014, 01:21

... Cytokine Growth Factor Rev 2003, 14:85-89. 7. Nakamura K, Kitani A, Strober W: Cell contact-dependent immunosuppression by CD4 + CD25 + regulatory T cells is mediated by cell surface-bound transforming ... Shevach EM: CD4 + CD25 + regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med 2002, 196:237-246. 12. Chen ... arthritis; SLE = systemic lupus erythematosus; TβR = TGF-β receptor; TCR = T-cell receptor; TGF = transforming growth factor; Th = T helper cell; Treg = regulatory T cell(s); TSP = thrombospondin. Arthritis...

Ngày tải lên: 09/08/2014, 06:22

... periosteum-derived cells by three members of the transforming growth factor-beta superfamily. J Orthop Res 1997, 15:463-467. 8. Izumi T, Scully SP, Heydemann A, Bolander ME: Transforming growth factor beta 1 stimulates ... tibia. Figure 3 Percentage of cells expressing transforming growth factor (TGF)-beta in medial and lateral tibial cartilagePercentage of cells expressing transforming growth factor (TGF)-beta in medial ... the common-Smad, Figure 2 Staining of various transforming growth factor (TGF)-beta signaling molecules in cartilageStaining of various transforming growth factor (TGF)-beta signaling molecules...

Ngày tải lên: 09/08/2014, 07:20

... balance between anabolic morphogens and growth factors and catabolic cytokines is at the crux of the problem of osteoarthritis. One such signal is transforming growth factor-β (TGF-β). The impaired ... (Drosophila melanogaster) involved as intracellular substrate for TGF-β and BMP signaling; TGF-β = transforming growth factor-β. Available online http://arthritis-research.com/content/8/1/101 Abstract Osteoarthritis ... this commentary is to place in context a recent article in this journal of anabolic growth factor, trans- forming growth factor-β (TGF-β) signaling in articular cartilage in aging mice [2]. This...

Ngày tải lên: 09/08/2014, 07:20

... low-density lipoprotein; SLICC, Systemic Lupus International Collaborating Clinics; TGF, transforming growth factor. Arthritis Research & Therapy Vol 8 No 3 Jackson et al. Page 2 of 7 (page ... disease (SLICC score 0). SLICC, Systemic Lupus International Collaborating Clinics; TGF, transforming growth factor. Available online http://arthritis-research.com/content/8/3/R81 Page 3 of ... Pearson test. PBMC, peripheral blood mononuclear cell; SLE, systemic lupus erythematosus; TGF, transforming growth factor. Arthritis Research & Therapy Vol 8 No 3 Jackson et al. Page 6 of 7 (page...

Ngày tải lên: 09/08/2014, 08:22

... RA synovial fluid in Figure 2 mRNA-expression of the transforming growth factor (TGF)-β related genesmRNA-expression of the transforming growth factor (TGF)-β related genes: (a) TGF-β1, (b) TGF-β2, ... name a Score b 1262_s_at/971_s_at TGFB2 Transforming growth factor, beta 2 0.521/0.404 1865_at SKIL SKI-like -0.480 1830_s_at/1634_s_at TGFB1 Transforming growth factor, beta 1 -0.529/-0.537 1866_g_at ... TGFB3 Transforming growth factor, beta 3 -0.618 1495_at LTBP1 Latent TGFB binding protein 1 -0.719 37906_at LTBP2 Latent TGFB binding protein 2 -0.751 1957_s_at/32903_at TGFBR1 Transforming growth...

Ngày tải lên: 09/08/2014, 10:20

... regulators insulin-like growth factor (IGF)1 and transforming growth factor (TGF)-β [93,94] STC1 Stanniocalcin inhibits calcium uptake and has inhibitory effect on bone growth during development ... Transforming growth factor, beta receptor I -4.915 1.049 NM_000118 A ENG Endoglin 4.131 -2.461 NM_001105 BOBACVR1 Activin A receptor, type I 3.791 -0.941 NM_003573 LTBP4 Latent transforming growth ... pathologies such as OP [32]. The identification of TGFB1 and BMP5, a member of the transforming growth fac- tor (TGF)-β superfamily, as OA susceptibility loci has impli- cated the TGF-β/BMP signalling...

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