transducer do dong dien va dien ap hieu dung

Báo cáo y học: "Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis" potx

Ngày tải lên : 09/08/2014, 10:20

... shows the highest prevalence [19] Ser82 enhances receptor signaling through mitogen activated protein (MAP) kinases and nuclear factor of kappa B (NF-κB) [18] The increased prevalence of Ser82 in ... aBonferroni correction applied Differences were tested by univariate Cox analysis, with the dependent variable time to event (from diagnosis of RA) CI, confidence interval; CV, cardiovascular; RA, rheumatoid ... Bonferroni correction for multiple comparisons All variables that were significant at p < 0.10 on univariate analysis were added to the multivariate model Variables significant at p < 0.05 on backwards,...

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Báo cáo y học: "levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control" docx

Ngày tải lên : 09/08/2014, 06:23

... S, Petrova RG, Abedin MJ, Li H, Yasui K, Takeuchi M, Makita Z, Takasawa S, et al.: Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial ... Methotrexate predominated and was used by 27 patients, either as a monotherapy (19 patients) or in combination with biological agents (six patients [anti-tumour necrosis factor alpha targeted therapy, five ... diabetes-induced vascular injury Biochem J 2003, 370:1097-1109 Park IH, Yeon SI, Youn JH, Choi JE, Sasaki N, Choi IH, Shin JS: Expression of a novel secreted splice variant of the receptor for advanced...

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Báo cáo y học: "erum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis" doc

Ngày tải lên : 09/08/2014, 13:22

... rheumatoid factor Immunol Lett 2004, 93:217-226 60 Vencovsky J, Machacek S, Sedova L, Kafkova J, Gatterova J, Pesakova V, Ruzickova S: Autoantibodies can be prognostic markers of an erosive disease in ... -2.63 0.01 -0.24 to -0.03 History of vasculitis -0.41 0.15 -2.68 0.009 -0.71 to -0.10 Variable Univariate analysis: Serum creatininea Multivariate analysis: Variables that were not listed in the ... Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury...

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Báo cáo y học: ":The expression of the receptor for advanced glycation end-products (RAGE) in RA-FLS is induced by IL-17 via Act-1" ppsx

Ngày tải lên : 12/08/2014, 17:22

... activator (Act1) is considered an essential protein for linking IL-17 receptors and downstream signaling pathways Act1 is a recently identified 60-kD cytoplasmic adaptor protein that activates ... promising target for regulating RAGE expression Abbreviations Act1: activator 1; AGEs: advanced glycation end-products; AP- 1: activator protein-1; Cp: crossing point; CRP: C-reactive protein; DMARDs: ... glycoxidation A new risk factor for cardiovascular disease? Cardiovasc Toxicol 2002, 2:275-287 Ramasamy R, Vannucci SJ, Yan SS, Herold K, Yan SF, Schmidt AM: Advanced glycation end products and RAGE:...

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Báo cáo khoa học: Analysis and biological relevance of advanced glycation end-products of DNA in eukaryotic cells ppt

Ngày tải lên : 30/03/2014, 04:20

... ethanol to precipitate sodium phosphate After ﬁltration, ethanol was removed by vacuum distillation with a rotary evaporator The mixture was separated by preparative HPLC in order to obtain both ... Perkin-Elmer PE200 autosampler (Boston, USA) and an Applied Biosystems API 2000 ESI-MS ⁄ MS instrument (Foster City, CA, USA) were used Chromatographic conditions were as follows: Agilent Zorbax ... achieved by several measures In particular, the solvent composition of the HPLC gradient, the thorough removal of RNA from the samples and the use of negative ionization for Fig Restriction digests...

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Báo cáo y học: " Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study" potx

Ngày tải lên : 12/08/2014, 13:22

... when neutrophils are activated [27] Similarly, S100A12 is secreted by cytokine-activated neutrophils [28] Since COPD is characterized by neutrophil activation, we thought it appropriate to measure ... statistically significant This means that both variables are important predictors of reduced sRAGE, but the effect of either variable does not vary in relation to the presence or absence of the ... Falaschi F, Rabinovich R, Canapini C, Roca J, Rabe KL: Value of chest radiography in phenotyping chronic obstructive pulmonary disease Eur Respir J 2008, 31:509-515 Haq I, Chappell S, Johnson SR, Lotya...

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Báo cáo y học: "Mechanical ventilation during experimental sepsis increases deposition of advanced glycation end products and myocardial inflammation" pdf

Ngày tải lên : 13/08/2014, 16:21

... Zoukourian C, Chappey O, Wautier MP, Guillausseau PJ, Cao R, Hori O, Stern D, Schmidt AM: Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy Soluble receptor for advanced glycation ... What role does the right side of the heart play in circulation? Crit Care 2006, 10(Suppl 3):S5 Begieneman MP, Goot FR van de, van dBI, Noordegraaf AV, Spreeuwenberg MD, Paulus WJ, van HV, Visser ... writing of the paper JWK performed the animal experiments and contributed to the writing of the paper CDS supervised the animal experiments and contributed to the writing of the paper AS supervised...

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Báo cáo khoa học: Advanced glycation end products and lipopolysaccharide synergistically stimulate proinﬂammatory cytokine⁄chemokine production in endothelial cells via activation of both mitogen-activated protein kinases and nuclear factor-jB pdf

Ngày tải lên : 30/03/2014, 01:20

... LPS and AGEs activate MAP kinases in various cells, including monocytes ⁄ macrophages and endothelial cells [12,24,25] In agreement with previous work, we also observed increased MAP kinase phosphorylation ... are intensively applied to these patients to control bacterial infection or to remove the metabolic toxic products from the body However, both therapeutic approaches might elevate LPS in the ... which requires both mitogen-activated protein (MAP) kinase and nuclear factor-jB (NF-jB) activation Results AGE-human serum albumin (HSA) and LPS stimulate a time- and dose-dependent cytokine ⁄ chemokine...

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Báo cáo y học: "Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells" doc

Ngày tải lên : 09/08/2014, 14:22

... MacLellan CM, Raptis M, Liu R, Pischon N, Trackman PC, Gerstenfeld L, Graves DT: Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways ... 34 Alikhani M, Maclellan CM, Raptis M, Vora S, Trackman PC, Graves DT: Advanced glycation end products induce apoptosis in fibroblasts through activation of ROS, MAP kinases, and the FOXO1 transcription ... through nuclear factor-kappa B, and by 17beta-estradiol through Sp-1 in human vascular endothelial cells J Biol Chem 2000, 275:25781-25790 37 Baier A, Meineckel I, Gay S, Pap T: Apoptosis in rheumatoid...

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Báo cáo y học: " Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats" pot

Ngày tải lên : 12/08/2014, 14:20

... modulates HSP47 expression in BLMstimulated pulmonary fibrosis It has been well-documented that TGFb1 appears to be the predominant isoform of TGFbs involved in pulmonary fibrosis, which exerts its ... induced a rapid Smad2 and Smad3 nuclear translocation and phosphorylation by normal rat tubular epithelial cells, glomerular mesangial cells, and vascular smooth muscle cells in a dose- and time-dependent ... Stein G, Wolf G: Advanced glycation end products and the kidney Am J Physiol Renal Physiol 2005, 289:F645-F659 Ramasamy R, Vannucci SJ, Yan SS, Herold K, Yan SF, Schmidt AM: Advanced glycation...

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báo cáo hóa học: " Imaging the effect of receptor for advanced glycation endproducts on angiogenic response to hindlimb ischemia in diabetes" docx

Ngày tải lên : 21/06/2014, 02:20

... DR, Ledbetter SR, Claffey KP, Papadopoulos-Sergiou A, Perruzzi CA, Detmar M: Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through ... M, Hoffman A, Levy AP: Vascular endothelial growth factor (VEGF) fails to improve blood flow and to promote collateralization in a diabetic mouse ischemic hindlimb model Cardiovascular Diabetology ... TJ, van Zonneveld AJ: Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type diabetes Diabetes 2004, 53:195-199 Tepper OM, Galiano RD, Capla...

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Báo cáo y học: "Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-α and matrix metalloproteinase-13 in human chondrocyte" ppsx

Ngày tải lên : 09/08/2014, 14:20

... these effects were concomitant with inhibited activation of the mitogen-activated protein kinase (MAPK) subgroups p38MAPK and JNK and the activation of the transcription factor NF-κB Our results ... (#9242), anti-phospho-p38 MAPK antibody (#9215S), anti-p38 MAPK antibody (#9212), anti-phospho-SAPK/JNK antibody (#9251S), antiSAPK/JNK antibody (#9252), anti-phospho ERK P44/42 MAPK antibody (#9101S) ... AGEBSA-induced gene expression of MMP-13 in a dose-depend- Effect of EGCG on the activation of MAPKs in AGE-BSAstimulated osteoarthritis chondrocytes Activation of MAPKs is intimately associated with the...

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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx

Ngày tải lên : 18/06/2014, 15:20

... Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury ... JO: Mapping Intramolecular Interactions between Domains in HMGB1 using a Tail-truncation Approach Journal of Molecular Biology 2007, 374:1286-1297 Pasheva E, Sarov M, Bidjekov K, Ugrinova I, ... Journal of Immunotherapy 2005, 28:1-9 Wang H, Bloom O, Zhang M, Vishnubhakat J, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L: HMGB-1 as a late mediator of endotoxin lethality...

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Báo cáo y học: "Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis." ppt

Ngày tải lên : 09/08/2014, 01:21

... lateral radiographs of the hands, wrists, feet, knees, and other affected joints were either available for evaluation or were obtained at the time of assessment Radiographs were available for analysis ... DMARD therapy (%) 41 39 19 12 Prednisone therapy (%) 36 44 26 11 Values are expressed as mean ± SD, unless otherwise stated *P < 0.001, †P < 0.05, versus like symbols by analysis of variance or ... (PBS) The IgG-AGE was measured by ELISA of the AGE proteins that were captured via cis-diols to the solid-phase immobilized APB APB (Sigma, Oakville, Ontario, Canada) mg/ml in 0.2 mol/l carbonate/bicarbonate...

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Báo cáo y học: "No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis" pdf

Ngày tải lên : 09/08/2014, 01:22

... is 0.4 For the locus variance, no formal data are available We decided to keep the less favorable value for a minor participation of the gene; this encouraged us to keep a variance for the locus ... Barrera P, Joosten LA, van Riel PL, Berg WB van den: The Toll-like receptor Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence ... antibody Erosions Gene SNP reference Transmitted/ untransmitted P value Transmitted/ untransmitted P value Transmitted/ untransmitted P value TLR1 rs5743618 (+7765 S602I) 33/28 0.52 34/29 0.53 32/32...

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Báo cáo y học: "Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish wome" pdf

Ngày tải lên : 09/08/2014, 07:20

... parathyroid tumors J Clin Endocrinol Metab 1998, 83:2255-2259 Available online http://arthritis-research.com/content/8/1/R20 52 van Saase JL, van Romunde LK, Cats A, Vandenbroucke JP, Valkenburg HA: Epidemiology ... aT haplotype = AATT + AATt + AAtt.dOne copy of the aT haplotype = AaTT + AaTt eTwo copies of the aT haplotype = aaTT Page of (page number not for citation purposes) Arthritis Research & Therapy ... carried out the genotyping analysis TV carried out the evaluation of hand radiographs KL participated in the evaluation of reliability of radiographs' readings HR conceived of the study and participated...

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Báo cáo y học: "No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis" ppt

Ngày tải lên : 09/08/2014, 13:22

... is 0.4 For the locus variance, no formal data are available We decided to keep the less favorable value for a minor participation of the gene; this encouraged us to keep a variance for the locus ... Barrera P, Joosten LA, van Riel PL, Berg WB van den: The Toll-like receptor Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence ... antibody Erosions Gene SNP reference Transmitted/ untransmitted P value Transmitted/ untransmitted P value Transmitted/ untransmitted P value TLR1 rs5743618 (+7765 S602I) 33/28 0.52 34/29 0.53 32/32...

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Báo cáo y học: " Glucocorticoid receptor gene polymorphisms associated with progression of lung disease in young patients with cystic fibrosis" doc

Ngày tải lên : 12/08/2014, 15:21

... 353(14):1443-1453 Yarden J, Radojkovic D, De Boeck K, Macek M Jr., Zemkova D, Vavrova V, Vlietinck R, Cassiman JJ, Cuppens H: Association of tumour necrosis factor alpha variants with the CF pulmonary ... coefficient) The D' values for the pairs were indicative of linkage disequilibrium (D' values between 0.17 to 0.99, and p values between 0.05 to

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Tài liệu Báo cáo khoa học: Complex transcriptional and translational regulation of iPLA2c resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization docx

Ngày tải lên : 19/02/2014, 16:20

... muscle, endothelial cell, hippocampus, testis, pituitary, placenta and pancreas The predominant splice variant isolated by 5¢-RACE, and the one most often present in the EST database, was splice variant ... for various time points after correction using concurrent Ó FEBS 2004 4712 D J Mancuso et al (Eur J Biochem 271) glyceraldehye-3-phosphate dehydrogenase (GAPDH) message ampliﬁcation with GAPDH ... speciﬁc activity, proteolytically activated form of the gene whose identity was substantiated by its covalent radiolabeling with (E)-6-(3H)(bromomethylene)-3-(1-naphthalenyl)-2H-tetrahydropyran-2-one...

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