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... patients, they did not detect any truncating mutation Therefore, we were able to confirm these results Nevertheless, they found the missense I157T mutation in 4.1% of the cases In this study, the incidence ... the presence of the 1100delC variant Discussion None of the investigated 91 patients with SCCHN carried the CHK2 1100delC variant The incidence of 1100delC in the population of the state NorthrhineWestphalia ... significant difference in the incidence of the CHK2 1100delC variant between the tumor group (0%) and the control group (0.9%) Compared to the study sizes of some other investigators, we only...

Ngày tải lên: 11/08/2014, 07:21

... it is unclear whether the polymorphism itself is functional or whether it is in linkage disequilibrium with one or more causal genetic variants If the latter was true, than this linkage disequilibrium ... plausible, the need for replication of this association has been raised [13] The aim of this study was therefore to validate and extend the reported association of the MHC2TA -168A>G polymorphism with ... Our results, which are in clear contrast to those previously published, could therefore be due to differences in linkage disequilibrium of the -168A>G polymorphism with the hypothesized causal...

Ngày tải lên: 09/08/2014, 08:22

... Genotypes were not significantly different, indicating that this polymorphism is not a susceptibility gene for RA (Table 1) To determine whether this marker influenced the disease phenotype, patients ... in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis Ann Rheum Dis 2005, 64:1780-1782 Page of (page number not for citation ... conclude from the results of the present large case–control study that there is no significant role of the A946T IFIH1 polymorphism in the genetic susceptibility to RA or with the development...

Ngày tải lên: 09/08/2014, 10:20

... differences for the -945CG polymorphism with plasma CTGF levels in DN and NA patients with diabetes We found that plasma CTGF levels were not associated with this polymorphism, which further questions ... carried out the genotyping assays, analyzed the data and wrote the manuscript TQN participated in the design of the study and helped revise the manuscript LB helped set up the genotyping assay ... with disease is not the same in all patient groups and categories, as has been noted in previous studies that could not always confirm the originally observed association of the -945GC SNP with...

Ngày tải lên: 11/08/2014, 07:21

... 1) The minor allele frequency (MAF) was 0.087, and the genotype distribution of the rs2234671 SNP in the CXCR1 gene was consistent with the assumption of the Hardy-Weinberg equilibrium for the ... forward stepwise multiple logistic regression analysis was used for estimating the relationships between the SNP rs2234671 in the CXCR1gene and periodontal disease susceptibility and the other covariates ... and in the CXCR2 genes with CP [26,27] Because those previous findings and the biological relationship of the CXCR-1 with the IL-8 and the CXCR-2 [1,5] we have hypothesized whether a SNP in the...

Ngày tải lên: 11/08/2014, 07:21

... 18.6a The patients with documented extra-digestive bleeding were excluded from this analysis aStatistical significance: p < 0.01 with univariate analysis bStatistical significance: p < 0.05 with ... [5,14,19] and might corroborate the low rate found with the swab sampling The exclusion from the study of the patients with a history of ulcers might have also contributed to this relatively low prevalence ... instructions The test was positive if the ratio between the optical density of the specimen and the mean optical density of the control was or more Clinical data The following clinical characteristics...

Ngày tải lên: 12/08/2014, 23:23

... introduces the advantages of skill-integration in teaching and learning reading and relationship between this skill and the other language skills Part C is the main part of the study It consists of ... overcome the exiting problems and improve all the four language skills in reading lessons in ESP for linguistics, this study is carried out It consists of three parts Part A is about the rationale, ... from being satisfactory To be more exact, the Communicative Approach is not properly applied and reading classes are often used to teach language rather than reading comprehension With the desire...

Ngày tải lên: 07/09/2013, 13:45

... biogenesis machinery For this purpose, we first performed spectral analysis of the authentic PHCP protein, aiming at the prediction of its structure, which is the final state of biogenesis Secondly, the ... whether or not the resulting variant is synthesized as a holo-protein with a covalently bound heme [10] Even without the DsbD protein or without co-expression of the ccm genes in a plasmid, the ... responsible residue is Tyr16 in the crystal structure of the AVCP protein [16] The same residue is also conserved in the PHCP protein (Fig 2) Other residues responsible for the maintenance of the hydrophobic...

Ngày tải lên: 06/03/2014, 00:20

... charity They know, they know, subjects But in the end, aU the same, they don't know all At the level of this not- all, there is nothing but the Other not to know It is the Other that makes not- all, ... the grasp of discourse 97 This Sex Which Is Not One Phallicism compensates for this discursive sustammg itself upon the Other, nourishing itself with the Other, desiring itself through the Other, ... ek-sistence Ek-sisting with respect to every form (of) "subject," it would not exist in itself The relation to the Other of/by I inl through the Other is impossible: "The Other has no Other. "...

Ngày tải lên: 31/05/2014, 02:04

... disease They were also excluded if they had a history of chronic illness such as: autoimmune disease, rheumatic disease, chronic infection or inflammatory disease, or other cancers Subjects with ... diagnosed for the first time during the enrollment period and their blood samples were collected before they received any treatment such as surgery, chemotherapy or radiotherapy This research was ... (normal group), 50 with IM including adenoma (high risk group), 40 with EGC (EGC group), 45 with AGC without distant metastasis (AGC group), and 42 with metastatic GC (M group) The clinical and...

Ngày tải lên: 18/06/2014, 15:20

... perpendicular to the longitudinal axis From these blocks, the CA3 was dissected by cutting along the edge of the DG and the CA1 and DG were dissected by cutting along the hippocampal fissure as described ... rather that an increased percentage of the existing microglial population is activated in the aged hippocampus Examination of the negative control slides incubated with secondary antibodies with ... three-group comparison with the aged group split into intact and impaired groups was performed to examine potential cognition specific-effects (ANOVA, with SNK pairwise comparisons, BHMTC) Statistical...

Ngày tải lên: 19/06/2014, 22:20

... [18] The innate immune response to viral infection depends on the integrity of this network of cytokines, which is tightly regulated [19] This in vivo situation led us to query whether the administration ... IFN-γ or their combination As a result we can envision that the administration of CDM in vivo could not affect the production of IFNs, which are so important mediators on the innate resistance ... here that IFN-α, together with IFN-γ synergistically inhibits the replication of HSV-2 in vitro like it was also demonstrated for HSV-1 and others DNA and RNA viruses On the other hand, we have...

Ngày tải lên: 20/06/2014, 01:20

... BRAND OVER TIME CX Engagement IT’S MORE THAN THE SUM OF ALL THEIR Plan EXPERIENCES COMBINED ACROSS A SINGLE BRAND CX Engagement IT IS IN FACT THE BASIS FOR BUILDING YOUR Plan IN A MORE BUSINESS ... Plan UX IT’S NOT ALL ABOUT THE USER Brought to you by Liljedal & Ivmark i! I’m H dal lilje ders an @ Engagement Plan Hi! I’m Ali Engagement Plan UX Engagement IT’S NOT ALL Plan ABOUT THE USER BUILDING ... LOYALTY Give them somet hing to rav e about ! BUILD IN CUSTOMER Engagement INCENTIVES, DEALS AND REWARDS Plan © Creuna 2011 20 AWARENESS Praise them y o u w lik e want pould r in retu aise rn! USE...

Ngày tải lên: 11/07/2014, 21:17

... variable anotherCounter is set to the incremented value of aLoopCounter By contrast, int anotherCounter = aLoopCounter++; sets anotherCounter to the value of aLoopCounter before it is incremented ... If the ++ operator is placed in front of the variable name, then it is a preincrement operator rather than a postincrement operator: int anotherCounter = ++aLoopCounter; In this example, the ... the name of the column (or columns) that form the foreign key in the local table In this case, the Customer_ID column of the CUSTOMER_CALL table references the column that is used as the basis...

Ngày tải lên: 07/08/2014, 14:20

... any phase of the cell cycle, although the exact mechanism through which bcl-2 inhibits apoptosis is not fully understood [19] In the presence of bcl-2 overexpression, the ability of the cell to ... from these tissues (such as lymph nodes with breast cancer metastasis), a relationship between bcl-2 expression and longer disease-free survival has been observed On the other hand, in other ... bcl2 Nevertheless, the characteristics of the primary lesion lose some importance once the first metastasis is diagnosed [3,22,27-29] The importance of data about the primary tumor is in fact...

Ngày tải lên: 09/08/2014, 07:21

... study [10] Another explanation for the discrepancy between the genotypic and the phenotypic data could be that unidentified linkages between mutations or polymorphisms in the MBL gene with mutations ... in the design of the study and reviewed the draft of the manuscript MRD participated in the design of the study, supervised the performance of the MBL pathway activity ELISA, and reviewed the ... the draft of the manuscript AEV participated in the design of the study, contributed to the coordination of the study, supervised the statistical analyses, and reviewed the draft of the manuscript...

Ngày tải lên: 09/08/2014, 08:23

... contour of the femoral head and to identify the center point The mid-plafond point is the point in the distal tibia directly over the center of the talar dome Three additional observers then completed ... potential mechanism for increased pull on the greater trochanter of the longer side, it is currently unclear whether there is an association between LLI and prevalent GTPS There is a need for research ... interests The authors declare that they have no competing interests Authors' contributions NAS developed the study hypotheses and analysis plan, participated in the statistical analysis, and drafted the...

Ngày tải lên: 09/08/2014, 10:23

... Arthritis Research & Therapy Vol 11 No Raterman et al Table Characteristics of the study population MetS presenta n = 84 MetS absenta n = 265 ... deviations) in cases of normal distribution or as medians (interquartile ranges) in cases of nonnormal distribution BMI, body mass index; CRP, C-reactive protein; DAS28, disease activity score using ... DMARD, diseasemodifying antirheumatic drug; ESR, erythrocyte sedimentation rate; HCQ, hydroxychloroquine; MTX, methotrexate; RA, rheumatoid arthritis; SSZ, sulfasalazine; TNF, tumour necrosis factor...

Ngày tải lên: 09/08/2014, 14:22

... Arthritis Research & Therapy Vol 11 No Toms et al Competing interests The authors declare that they have no competing interests Acknowledgements This work is supported by an Arthritis Research ... glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study Arthritis Res Ther 2008, 10:R145 Page of (page number not for citation purposes) ... reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60: more than just an anti-inflammatory effect? A crosssectional study Arthritis Res Ther 2009, 11:R110...

Ngày tải lên: 09/08/2014, 14:22

... prevent SSIs In summary, the PaO2 in adult cardiac surgery patients is not related to SSI rate The strategy of administering supplemental inspired oxygen to reduce the incidence of SSIs does not appear ... associated with an increased risk of SSI either by univariate or multivariate analysis (Table 1) The 30-day mortality rate was similar in both groups: patients without SSIs, n = 72 (7.4%) vs patients with ... Characteristics and preoperative, intraoperative, and postoperative data for patients with and without surgical site infections (SSIs) Characteristics Patients Without SSI (n = 970) Patients With...

Ngày tải lên: 10/08/2014, 09:23