time line of major events in dod s i
Tài liệu Why Has The Cost of Navy Ships Risen - A Macroscopic Examination of the Trends in U.S. Naval Ship Costs Over the Past Several Decades doc
... expectation of such comparisons is that naval shipbuilding retains many of the dynamics of the commercial shipbuilding industry This report addresses, in part, Why Has the Cost of Navy Ships Risen? ... some insight into its underlying reasons For example, if the increase is continuous and steady, then escalation may be due to a systemic issue such as the increase of shipbuilding input cost (e.g., ... medical facilities All these capabilities must be sustained for several months at sea, requiring a significant amount of equipment and provision storage These nonmission capabilities of warships...
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Tài liệu Why Has the Cost of Fixed-Wing Aircraft Risen - A Macroscopic Examination of the Trends in U.S. Military Aircraft Costs over the Past Several Decades pptx
... chose this approach to minimize distortions caused by examining trends over differing periods of time If we were to examine the simple increase in price (i. e., final to initial cost), our results would ... means it is a fighter/attack mission aircraft, the 18th in the series of aircraft of that mission designated by DoD, and it is the 5th and 6th series within that mission and design Why Has the Cost ... cost estimators with factors useful in adjusting and creating estimates based on parametric cost-estimating methods In Military Jet Engine Acquisition: Technology Basics and CostEstimating Methodology,...
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Tài liệu Bike Lanes, On-Street Parking and Business: A Study of Bloor Street in Toronto’s Annex Neighbourhood docx
... The purpose of this study is to understand and estimate the importance of on‐street parking to business. Regardless of the specific findings of the study, the project is intended to increase the ability of Canadian municipalities to better determine the public acceptability and economic ... customers drive to their business. In fact, only 4% of businesses believe that more than 50% of their customers drive to their business, and almost three‐quarters of businesses believe that less than 25% of customers drive to their business. Therefore, according to most merchants (71%), ... time. During the week, the busiest time for parking is in the Figure 17 Palmerston parking lot evening with 66% utilization. On Saturdays, the busiest time is also in the evening with 82% utilization. Saturday evening is the ...
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Báo cáo khoa học: Lack of stabilized microtubules as a result of the absence of major maps in CAD cells does not preclude neurite formation pot
... sustaining neurites Discussion Our understanding of neurogenesis, neuronal plasticity, and the establishment of correct synapses and circuits in the central and peripheral nervous systems has ... Tau, and STOP proteins was surprising This led us to investigate the presence of their respective genes and messenger RNAs, using a PCR technique with specifically designed primers (Table 1) In every ... neurons in culture Results Cytoskeletal proteins As noted in the Introduction, the stabilization of microtubules is recognized as an essential process during the elongation of neurites, presumably...
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báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
... closely associated with SPs, NFTs, and dystrophic neurites in the AD brain These findings are in agreement with in vitro studies indicating that Aβ and tau protein, the major components in SPs ... administration of rosmarinic acid on glial cell proliferation (microgliosis and astrocytosis), plaque load, and memory (Morris water maze) in Aβinfused rats Rosmarinic acid inhibits both the classical ... deposits are thioflavin -S- positive and are associated with reactive astrocytes Phosphorylated tau initially appears in the hippocampus and subsequently in cortical regions; it is detected within...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... inhibition of src-family tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production These findings suggest that these kinases are involved in upstream signaling ... studies demonstrated a ~70% reduction in AD incidence among patient populations receiving statin treatment [117,118] Despite these promising findings, the use of statins in prospective clinical ... addition to their ability to lower low-density lipoproteins, statins exhibit additional pleiotropic effects including modulation of inflammatory processes The anti-inflammatory actions of statins...
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báo cáo hóa học: " Psychometric validation of the revised SCOPADiary Card: expanding the measurement of nonmotor symptoms in parkinson’s disease" potx
... domains for discussion in the focus groups of PD patients with off -time: feelings of anxiety, mood swings, loss of interest, fatigue and autonomic or gastrointestinal symptoms (such as excessive ... the patient s responses A single item assessing off -time (yes/no) at each time point was included for validation purposes Participants of the cognitive debrief indicated that the Revised SCOPA-DC ... differences in mean CV and SD scores was tested using the Mann-Whitney test Significance testing was not conducted if the sample size was less than Prediction of off -time Longitudinal binary logistic...
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Báo cáo hóa học: "Research Article On the Precise Asymptotics of the Constant in Friedrich’s Inequality for Functions " potx
... homogenization theory and in fact this was our original interest in the subject The paper is organized as follows In Section 2, we present and discuss our main results In Section 3, these results ... proved via some auxiliary results, which are of independent interest In Section 4, we consider partial cases, where it is possible to give the asymptotic expansion for the constant with respect ... nonperiodic geometry are considered in [19] In the paper the author constructed and verified the asymptotic expansions of eigenvalues Keeping in mind these results it is possible to obtain sharp...
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Báo cáo hóa học: " Research Article Detection and Separation of Speech Events in Meeting Recordings Using a Microphone Array" docx
... topic of a meeting should be investigated Use of visual information is another interesting topic to be investigated in the future In this paper, the seats of the meeting participants were assumed ... meeting, a professional interviewer asks questions regarding a product and has a discussion with interviewees The number of interviewees in the recorded meeting was five The interviewer was female ... EURASIP Journal on Audio, Speech, and Music Processing Input signal Sound localization Range of speaker Information on speech events Estimation of steering vector Sound source clustering Estimation...
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Báo cáo y học: "No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis" pdf
... polymorphism constituting a noncoding mutation in intron at position +214; this SNP did not exhibit sufficient polymorphism in the participants to allow genotyping in the association study Toll-like ... (rs5743618) SNPs are associated with invasive aspergillosis [21] and with Crohn 's disease [20] The TLR6 Ser249Pro SNP (rs5743810) is associated with a reduced risk of asthma and an increased risk of invasive ... our findings Definitive proof that autoantibodies are involved in the pathophysiology of RA is still lacking, despite accumulating evidence of a role for B cells – including the efficacy of secondline...
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Báo cáo khoa học: "Mucin pattern reflects the origin of the adenocarcinoma in Barrett''''s esophagus: a retrospective clinical and laboratorial study" ppsx
... epithelium and tumor Characteristics Patient Cell type (gastric or intestinal) predominance in the specialized columnar epithelium 10 11 12 13 intestinal intestinal similar intestinal Gastric ... Gastric Gastric Gastric Intestinal Gastric similar similar Gastric Intestinal Adenocarcinoma Grade of IHC IHC Type of tumor differentiation MUC2 MUC5AC according to mucins well + Intestinal moderated ... present in the human intestine, mostly in goblet cells [26] The glycopeptide in MUC2 is rich in cysteine residues with disulphide bonds This results in polymerization and contributes to the intrinsic...
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Báo cáo y học: "Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis" potx
... 364:937-952 Dessein PH, Stanwix AE, Joffe BI: Cardiovascular risk in rheumatoid arthritis versus osteoarthritis: acute phase response related decreased insulin sensitivity and high-density lipoprotein cholesterol ... viscosity, in addition to short-term improvements in endothelial function and arterial stiffness [33-37] Of clinical importance, this is the first study to show that statins significantly influence ... amplifying inflammatory events in tissues previously sensitized by lipid deposition or inflammatory triggers [12] RAGE is expressed at low levels in normal tissues but upregulated at sites of vascular...
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Báo cáo y học: " Interrelated modulation of endothelial function in Behcet''''s disease by clinical activity and corticosteroid treatmen" ppt
... endothelial dysfunction in the atherosclerotic process, as well as its reversibility, have been confirmed in various clinical settings, including systemic vasculitis, rheumatoid arthritis, systemic ... chronic inflammatory diseases Interestingly, administration of corticosteroids improves endothelial function in patients with giant cell arteritis, which is the most common primary vasculitic disease ... of their symptoms at day Discussion The main finding of the cross-sectional observational study was that endothelial function in patients with BD is modulated by both clinical disease activity...
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Báo cáo y học: "No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis" ppt
... polymorphism constituting a noncoding mutation in intron at position +214; this SNP did not exhibit sufficient polymorphism in the participants to allow genotyping in the association study Toll-like ... (rs5743618) SNPs are associated with invasive aspergillosis [21] and with Crohn 's disease [20] The TLR6 Ser249Pro SNP (rs5743810) is associated with a reduced risk of asthma and an increased risk of invasive ... our findings Definitive proof that autoantibodies are involved in the pathophysiology of RA is still lacking, despite accumulating evidence of a role for B cells – including the efficacy of secondline...
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Báo cáo y học: "Predictors of major infections in systemic lupus erythematosus" pptx
... increase the risk of infection in one recent study [15] It is thus a difficult task to identify lupus patients at high risk of serious infectious complications The inclusion in some studies of ... endocarditis, meningitis), requiring hospital admission for treatment (severe soft tissue infection, disseminated Varicella zoster) or causing death The diagnosis of infection was always made ... identified as a risk factor in several studies [4,6,8,9], but not in all series [2,3,5,7] Renal disease, despite being associated with infections in the univariate analysis in some series, has not...
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Báo cáo y học: "Sinus of valsalva aneurysm in Blau’s syndrom" ppt
... arteries is performed in patients with a dilated annulus and multiple sinus involvement, where simple plication or patch repair is not possible In isolated unruptured aneurysms of a sinus of Valsalva ... striking similarities of the core triad (arthritisuveitis-dermatitis) and a common emerging pattern of systemic involvement Hence, the familial form (BS) and the sporadic form (EOS) are almost ... trace of normal tissue is seen in this area In both the right and the non-coronary sinuses there was a large saccular aneurysm lined with mural thrombus Fig (2, 3) The aortic sinuses were excised...
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báo cáo khoa học: " Multi-drug resistance 1 genetic polymorphism and prediction of chemotherapy response in Hodgkin’s " pot
... genotype Statistical analysis Data analysis was carried out using the statistical package SPSS version 17 to compute all descriptive statistics Chi-square and Fisher exact tests were used to evaluate ... genotype distribution and allele frequencies of the studied polymorphism A P value of < 0.05 was considered statistically significant Hardy-Weinberg equilibrium was assessed using the chi-square test ... Cyclophosphamide, Vincristine, Prednisolone, Procarbazine Discussion In this study, we investigated for the first time whether functional polymorphism C3425T in MDR1 gene could affect patient s susceptibility...
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báo cáo khoa học: " Whole-Organ analysis of calcium behaviour in the developing pistil of olive (Olea europaea L.) as a tool for the determination of key events in sexual plant " ppsx
... successful injection of the Ca2 + -sensitive dye Fluo-3 into inflorescences as a useful tool for in situ Ca2+ localization in the intact pistils Results Experimental design In situ detection of ... which showed distinguishable signs of degeneration (Figure 8E) Discussion Here, we used fluorescence microscopy for the in situ localization of Ca2+ ions in intact olive pistils after Fluo3 AM injection ... measure intracellular Ca2+ ions by using microscopy imaging techniques To introduce this dye into intact pistils, we injected the Fluo-3 solution directly into olive inflorescences To Page of...
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Báo cáo khoa học: "Time course of endothelial damage in septic shock: prediction of outcome" pptx
... failure and guidelines for the use of innovative therapies in sepsis The ACCP/SCCM Consensus Conference Committee American College of Chest Physicians/Society of Critical Care Medicine Chest ... colleagues observed an increase in sICAM-1 and sELAM-1 levels for 3–4 days after study inclusion in non-survivors, sELAM-1 then returning to levels similar to those observed in survivors whereas sICAM-1 ... differences in signs of myocardial ischemia between survivors and non-survivors The high incidence of myocardial ischemic signs observed in the ECGs has to be interpreted carefully Other studies...
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