three states of gal1 10 gene expression
Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues ppt
Ngày tải lên :
06/03/2014, 19:20
... 11.1 10. 7 Te 2.8 7.5 10. 3 36.6 We next determined gene expression in different adipose depots in response to PM2.5 exposure, in terms of the expression of BAT-specific and WAT-specific gene profiles ... targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis Diabetes 2004, ... exposure We did not observe significant differences in the gene expressions of Hoxc9 or Igfbp3 in the WAT, neither was the gene expression of Dpt in BAT or WAT Xu et al Particle and Fibre Toxicology...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
Ngày tải lên :
07/03/2014, 01:20
... formation of transcription complexes This aspect of ABPs is entirely novel and would not have been predicted 10 years ago As an interesting note, modulation of nuclear ABPs on target gene expression offers ... can facilitate recruitment of PCAF or P2D10 to the active gene Formation of actin filaments in the proximity of the Pol II C-terminal domain may help establish a network of interactions between the ... transcriptional activity by MEF2 Second, overexpression of a-actinin-4 decreases the interaction of MEF2A and HDAC7 Third, knockdown of a-actinin-4 decreases expression of TAF55 Fourth, MEF2C, a-actinin-4...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
Ngày tải lên :
08/03/2014, 08:20
... the expression profile of the Cyr61/CCN1 gene to that of the CTGF/CCN2 gene and showed that S1P coordinately regulates the expression of both Cyr61/ CCN1 and CTGF/CCN2 but the final level of control ... increase of Cyr61/CCN1 mRNA levels than those of Fig Stimulation of Cyr61/CCN1 gene expression by S1P (A) Relative mRNA levels of Cyr61/CCN1 in cells treated with S1P Cells were treated with S1P (10 ... (1990) Expression of cyr61, a growth factor-inducible immediate-early gene Mol Cell Biol 10, 3569–3577 Tamura, I., Rosenbloom, J., Macarak, E & Chaqour, B (2001) Regulation of Cyr61 gene expression...
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Báo cáo khoa học: Efficient inhibition of b-secretase gene expression in HEK293 cells by tRNAVal-driven and CTE-helicase associated hammerhead ribozymes doc
Ngày tải lên :
08/03/2014, 08:20
... this expression system is of interest for endogenous generation of siRNA and activation of the RNAi effect in human cells [45] Studies on an inhibition of BACE gene expression by endogenously generated ... BACE mRNA expression in the cells transfected with lipofectin only (NO) and lysed after 48 h increase of the BACE mRNA level because of the lower expression of ribozyme A similar profile of the target ... the cleavage of phosphodiester bonds in RNA This ability makes ribozymes useful molecular tools for very selective degradation of mRNA and inhibition of expression of the genes of ÔunwantedÕ...
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Báo cáo khoa học: Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 gene expression docx
Ngày tải lên :
16/03/2014, 18:20
... expression of a protein(s) required for induction of the Timp-1 gene Time course of TSA action upon PMA- and TGF-b1-induced Timp-1 expression The time course of induction of Timp-1 gene expression ... involvement of acetyl1914 Representative dose–response curves of the effect of HDACi’s on either PMA- or TGF-b1-induced Timp-1 gene expression are shown in Fig 2A–C For PMA induction of Timp-1 expression, ... repressive nature of the first intron of the Timp-1 gene by binding Sp1 and Sp3, along with an Ets-related factor [10] Recently, our laboratories have examined the induction of Timp-1 gene expression...
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Báo cáo khoa học: Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells pot
Ngày tải lên :
16/03/2014, 22:20
... Inhibition of uPAR by DNAzymes all of which contribute to focal proteolysis and regulation of wound healing, angiogenesis, and metastasis [5] Of the components of the uPA system, uPAR is of particular ... methods for suppressing gene expression, they have a number of limitations; a useful review can be found elsewhere [18] The DNAzyme technique offers a new way of suppressing gene expression In comparison ... Columns, means of three separate experiments normalized to b-actin expression and as a fraction of untreated control Statistical evaluation showed that the effect of Dz720 in reduction of uPAR protein...
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Báo cáo khoa học: Analysis of dopamine transporter gene expression pattern ) generation of DAT-iCre transgenic mice doc
Ngày tải lên :
30/03/2014, 08:20
... Discussion Transgenesis with small DNA regions regulating transcription is inherently prone to problems of ectopic expression, mosaic expression or the absence of expression, due to the influence of genomic ... the Cre transgene at the level of the ATG of the DAT gene The iCre ORF is represented as a white rectangle, whereas intron sequences and the polyadenylation signal of the bovine GH gene are shown ... Fig Expression of Cre recombinase in the midbrain dopaminergic nuclei of BAC-DATiCre mice (A) Schematic representation of the BACDATiCre construct and its structure The position of the DAT gene...
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Báo cáo hóa học: " Evolutionary Techniques for Image Processing a Large Dataset of Early Drosophila Gene Expression" pptx
Ngày tải lên :
23/06/2014, 01:20
... stripes The regularity of the kni 123 eve hairy Figure 10: Three- dimensional diagrams representing dynamics of AP profiles of expression for the gap genes gt, hb, kni, and pairrule genes eve and hairy ... direction Figure 10 allows us to examine a number of features of cycle 14 expression dynamics Gap genes tend to establish sharp spatial boundaries earlier than the pair-rule genes Pair-rule genes are ... dataset of gene expression in time class (late cycle 14) for the gap genes hunchback (hb), giant (gt), Kr¨ ppel, and knirps(kni) and the pair-rule gene eve Each surface u is the gene expression...
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Báo cáo y học: "Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specime" pot
Ngày tải lên :
09/08/2014, 06:23
... focused on the analysis of gene- expression profiles characteristic of proliferative lesions in the synovial lining tissues, which are one of the initial histopathological events of synovitis in early ... Candidate gene profiles in each group Using the SAM software, we examined 1,035 genes to find which were expressed significantly differently in groups I and II We found that the expression of 180 genes ... On the basis of these findings, we speculate that the two groups may reflect differences in the pathogenesis of synovitis The different expression profiles of several candidate genes for RA reported...
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Báo cáo y học: "Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis" pptx
Ngày tải lên :
09/08/2014, 06:23
... status of the chondrocyte is central to our understanding of the initiation and progression of osteoarthrits (OA) [16] An initial anabolic response of chondrocytes in OA includes an upregulation of ... cartilage undergoing OA degeneration or are more generalized within arthritic joints An understanding of the changes that occur with the onset and progression of cartilage degeneration in R853 OA ... model of OA [22,23,33] The present study extends these earlier investigations by examining the expression of a number of important extracellular matrix components at the mRNA level One of the...
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báo cáo khoa học: " Downregulation of CDKN2A and suppression of cyclin D1 gene expressions in malignant gliomas" doc
Ngày tải lên :
10/08/2014, 10:21
... were replated in 10 cm2 plates and maintained in selection medium containing 800 μg/ ml of G418 (GIBCO) Cultures were replated in the densities of × 103 , × 102 , or 2.5 × 102 on 10 cm2 plates in ... important positive regulator of the cyclin-Rb signaling pathway involved in carcinogenesis of glioma To confirm the role of CDKN2A in gliomas, we detected the levels of CDKN2A expression in 61 glioma ... changes in expression of cell cycle regulatory proteins Overexpression of CDKN2A had same effects on the CDKN2A-Cyclin-Rb pathway proteins in various cell lines (Figure 4) After overexpression of CDKN2A...
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báo cáo khoa học: "Induction of endogenous γ-globin gene expression with decoy oligonucleotide targeting Oct-1 transcription factor consensus sequence" pps
Ngày tải lên :
10/08/2014, 22:20
... exploration of up-regulation of gene expression for the desired target genes using the decoy oligonucleotide strategy although the clinical relevance of up-regulation of target genes for the treatment of ... transcription as well as for the transcription of a number of housekeeping genes [10] Studies reveal that the promoter region of each of the human γglobin genes carries three Oct-1 transcription factor consensus ... can be used to induce expression of the endogenous γ-globin gene Since increased expression of the γ-globin gene has already shown its clinical benefit in the treatment of β-globin disorders...
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Báo cáo y học: "Translating three states of knowledge–discovery, invention, and innovation" pot
Ngày tải lên :
11/08/2014, 05:21
... meet its goal of providing more effective technology-based health services and products [13] Three states of knowledge Three methods of activity generate three different states of knowledge Research ... each state of knowledge dependent on the others The three states of knowledge are analogous to the three classic states of matter This analogy will help clarify why the implementation of science ... knowledge Research activity generates knowledge in one state, while development activity and production activity generate knowledge in different states The three states of knowledge represent a...
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Báo cáo y học: "JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin" ppsx
Ngày tải lên :
11/08/2014, 08:22
... of A NF-κB κ NF-κB κ 10 20 50 10 20 10 50 SP (μM) BV (5 μg/ml) 20 50 SP (μM) 10 20 50 SP (μM) Melittin (10 g/ml) BV (5 μg/ml) SNP (200 μM) Melittin (10 g/ml) LPS (1 μg/ml) B NF-κB κ NF-κB κ 10 ... 7000 5000 4000 3000 2000 5000 4000 3000 2000 100 0 100 0 0 10 20 BV (5 μg/ml) 10 20 SP (μM) 10 Melittin (10 μg/ml) LPS (1 μg/ml) 10 20 SP (μM) Melittin (10 μg/ml) SNP (200 μM) D B 4000 6000 5000 PGE2 ... (5 μg/ml) 4000 3000 2000 3000 2000 100 0 100 0 0 10 20 BV (5 μg/ml) 10 20 SP (μM) Melittin (10 μg/ml) LPS (1 μg/ml) 10 20 BV (5 μg/ml) 10 20 SP (μM) Melittin (10 μg/ml) SNP (200 μM) Figure JNK inhibitor...
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báo cáo khoa học: " Translating three states of knowledge–discovery, invention, and innovation" pps
Ngày tải lên :
11/08/2014, 16:20
... meet its goal of providing more effective technology-based health services and products [13] Three states of knowledge Three methods of activity generate three different states of knowledge Research ... each state of knowledge dependent on the others The three states of knowledge are analogous to the three classic states of matter This analogy will help clarify why the implementation of science ... knowledge Research activity generates knowledge in one state, while development activity and production activity generate knowledge in different states The three states of knowledge represent a...
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báo cáo khoa học: " Characterization of Vitis vinifera NPR1 homologs involved in the regulation of Pathogenesis-Related gene expression" ppsx
Ngày tải lên :
12/08/2014, 03:20
... (587 aa) LeNPR1 NtNPR1 100 363 288 MNPR1A 100 100 134 VvNPR1.1 (584 aa) 100 BTB/POZ Ankyrin repeat NLS 99 VvNPR1.1 AtNPR2 100 AtNPR1 100 AtNPR4 AtNPR3 100 100 MpNPR1-1 100 VvNPR1.2 AtBOP2 AtBOP1 ... the expression profile of the two grapevine NPR1 genes, detached leaves of Vitis vinifera cv Chardonnay were treated with a solution of BTH (a SA analog) We also monitored the expression of a ... control the expression of PR genes (especially the PR1 gene) , PR protein accumulation was analyzed after transient expression of AtNPR1-GFP, VvNPR1.1-GFP and VvNPR1.2-GFP Leaves of N benthamiana...
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Báo cáo y học: " Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase P" pptx
Ngày tải lên :
12/08/2014, 04:20
... whereas a reduction of less than 10% was found in the C-EGS324 treated cells Inhibition of UL49 expression is not expected to affect the expression of other viral genes Figure Cleavage of the 32 P-labeled ... in the expression of IE2, UL44, pp28, and gB (Table 1) The observed level of inhibition of UL49 expression was consistent with the extent of the reduction of viral growth HCMV is a member of the ... March 2 010 Accepted: 18 May 2 010 Published: 18 May 2 010 © 2 010 Zhang Access from: BioMed Central Ltd terms of the Creative This is an Openet2 010, 7 :100 http://www.virologyj.com/content/7/1 /100 Commons...
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Retrovirology Commentary BioMed Central Open Access Inhibition of HIV-1 gene expression by pptx
Ngày tải lên :
12/08/2014, 23:20
... Sam68ΔC Understanding regulation of Understanding regulation of HIV-1 gene expression by Sam68ΔC (A) Following transcription, HIV-1 RNA undergoes alternative splicing to generate over 40 mRNAs that ... selective repression of Nef expression may require a different mechanism than that outlined by Marsh et al Inhibition of Nef expression was reported to be associated with the accumulation of nef mRNA ... selectively inhibits the expression of several key HIV-1 mRNAs will provide important insights into their regulation and potentially lead to new approaches to controlling the pathogenesis of this virus...
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Báo cáo y học: " Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A" potx
Ngày tải lên :
12/08/2014, 23:22
... Depletion of eIF5A by siRNA inhibits gene expression from Depletion of eIF5A by siRNA inhibits gene expression from HIV-1 molecular clone A Depletion of eIF5A 293T cells were transfected with 50 nM of ... Inhibition of eIF5A production reduces HIV gene expression The findings described to this point establish a correlation between inhibition of eIF5A modification and inhibition of HIV-1 gene expression ... C Figure Inhibition of gene expression by CPX and DEF is promoter specific Inhibition of gene expression by CPX and DEF is promoter specific A-C Inhibition is independent of Tat Total RNA was...
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Báo cáo y học: "Threshold-free high-power methods for the ontological analysis of genome-wide gene-expression studies." pptx
Ngày tải lên :
14/08/2014, 07:21
... control the types of categories modeled: the number of genes in the category (N); the proportion of modulated genes (π); and the mean and standard deviation of the modulated gene scores (μ and ... mean (effect size) of the modulated gene scores (μ), and the standard error (effects spread) of the modulated gene scores (σ) The parameter values were: N = 10, 30 and 100 genes, which are typical ... R, Hochhaus A, Seifarth W: Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis Leukemia 2006, 20 :102 8 -103 4 ArrayExpress repository...
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