therapeutic utility of proteasome inhibitors for acute leukemia

... shown) Use of synthetic peptidyl-CoAs with Sfp and PCP-E bidomain constructs for assaying epimerization activity The first aim of this study was to develop an assay for the investigation of E domain ... relative values of l- ⁄ d-isomers were calculated easily by determining the area of the ion extracted MS signals Therefore, the use of an internal standard was not necessary for quantification ... was possible to resolve formation of converted peptidyl substrates in dependence of time (Fig 5) (the margin of error, as estimated by up to four independent determinations of each time curve, was...

Ngày tải lên: 30/03/2014, 20:20

... may be one of the molecules to target and the combination with other signal pathway inhibitors may be an alternative of therapeutic strategies for ALI/ ARDS Contributions MTW: performing the ... Committee of The Second Military University and performed in accordance with the Guide for the Care and Use of Laboratory Animals The rabbits were anesthetized with intravenous injection of 20% ... collected and centrifuged at 3000 × g for and the serum was stored at -80°C for the measurements of TNF-a and ICAM-1 assay and isolation of PMNs The same volume of fluid was replaced in all animals...

Ngày tải lên: 18/06/2014, 19:20

... may be one of the molecules to target and the combination with other signal pathway inhibitors may be an alternative of therapeutic strategies for ALI/ ARDS Contributions MTW: performing the ... Committee of The Second Military University and performed in accordance with the Guide for the Care and Use of Laboratory Animals The rabbits were anesthetized with intravenous injection of 20% ... collected and centrifuged at 3000 × g for and the serum was stored at -80°C for the measurements of TNF-a and ICAM-1 assay and isolation of PMNs The same volume of fluid was replaced in all animals...

Ngày tải lên: 20/06/2014, 03:20

... for conditioning; Phenytoin for prophylaxis of busulfan’s side affect Tacrolimus; methotrexate and mycophenolate mofetil (0.5 g twice a day on days to +28) for GVHD prophylaxis; Caspofungin for ... provision of clinical care of the patient and the collection of data and the review of the manuscript GPY: supplied the acquisition of data, analysis and interpretation of data, drafting of manuscript; ... little description of the onset of hyperbilirubinemia in GS patients who received HSCT Ruiz-Arguelles GJ, et al [2] reported seven cases of acute leukemia with coexisting GS, of which patients...

Ngày tải lên: 10/08/2014, 21:23

... project of the Institute of Economic Research and the World Bank Poverty prevalence was defined as the million VND income poverty line of set by the People’s Committee of HCMC Quartiles of district-level ... the poverty prevalence estimates for each district Analytic Approaches Time-series analysis: The unit of observation is daily counts of hospital admissions for acute lower respiratory infection ... the growing literature on the health effects of air pollution in Asia This is, to the best of our knowledge, the first ever study of the health effects of air pollution in Ho Chi Minh City In addition,...

Ngày tải lên: 13/09/2015, 17:48

... inhibition efficiency of the organic corrosion inhibitor layers These factors include the type of solvent used, concentration of inhibitors, type of inhibitors, and duration of deposition For example, ... a single monolayer of inhibitors for corrosion inhibition However, defects could be present in single layers of organic inhibitors and depositing multiple layers of organic inhibitors may be able ... Tunability of surface properties – the chemical composition of the film can be tailored by design and synthesis of adsorbates Conformality – film formation is conformal, allowing objects of any shape...

Ngày tải lên: 13/10/2015, 16:50

... indicate better QoL Analysis The Statistical Package for Social Sciences for Macintosh version 18.0 was used for all data analyses For the description of demographic variables and questionnaire scores, ... participation, reasons for not Page of participating are unknown for the another child No demographic information was available on these children Questionnaires were not returned for one child (a 10 ... and off-dex were not significantly different Quality of Life QoL (both on-dex and off-dex) was lower in ALL compared to Dutch CHQ population norms This was significant for all scales except for...

Ngày tải lên: 20/06/2014, 15:20

... recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia J ... H, McIntyre OR, Schiffer C: A comparative study of two different doses of cytarabine for acute myeloid leukemia: a phase III trial of Cancer and Leukemia Group B Blood 1991, 78(10):2520-2526 31 ... References Freireich EJ: Four decades of therapy for AML Leukemia 1998, 12 Suppl 1:S54-56 Zhu X, Ma Y, Liu D: Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights...

Ngày tải lên: 10/08/2014, 21:23

... creatinine levels were determined before each course of chemotherapy Electrocardiograms were performed on all patients before chemotherapy Patients with karyotypes of t(8;21), inv(16), or t(16;16) ... achievement of CR as the following: HA regimen as described above, DA (DNR, 30 mg/m2 daily for days, Ara-C 100 mg/m2 daily for days) or IDA (idarubicin, mg/m2 daily for days, Ara-C 100 mg/m2 daily for ... Survival analysis was performed by the Kaplan-Meier method using the SPSS 13.0 software Results Characteristics of the patients Characteristics of the patients at the time of diagnosis are listed...

Ngày tải lên: 10/08/2014, 22:20

... secondary to this increased risk of GVHD Page of With median follow up for living patients of 54 months (range 11 - 90) for Bu/CY and 28 months (range CI 54) for t-IV Bu/Flu, median OS was months ... class of K-sample tests for comparing the cumulative incidence of a competing risk Annals Of Statistics 1988, 16:1141-1154 Fine JA: A proportional hazards model for the subdistribution of a competing ... in a comparative analysis of outcomes of AML patients Methods Patients All consecutive acute myelogenous leukemia (AML) patients treated with a conditioning regimen of targeted IV busulfan and...

Ngày tải lên: 10/08/2014, 22:21

Ngày tải lên: 13/08/2014, 03:20

... functioning of the ubiquitin proteasome pathway is essential for the degradation of the majority of intracellular proteins and is implicated in many cellular processes, including regulation of apoptosis ... semiquantitative RT-PCR For detection of c-Jun expression, RT-PCR with GAPDH serving as an internal control (in the same PCR reaction) was performed (30 cycles for c-Jun and 30 cycles for GAPDH) Similar ... of DR5 in glioma cells To elucidate the underlying molecular mechanisms of the observed synergistic effects of PIs, we focused on the transcriptional activation of pro-apoptotic genes after proteasome...

Ngày tải lên: 18/02/2014, 17:20

... the utility of these approximations of the SPADE-like context-free features The performance of the resulting “Full” finite-state system is not statistically significantly different from that of ... percentages from to 100 For a string of length k, at position i, we round i/k to two decimal places and provide a value of for the corresponding quantized position feature and for the other position ... system could perform as well as the SPADE system, which uses context-free parse trees, this does not directly answer the question of the utility of context-free derived features for this task SPADE...

Ngày tải lên: 08/03/2014, 02:21

... Part of the reason for the lack of complementation of the gametophyte phenotypes is probably because of an absence of 35S promoter expression in the anthers [33] The detailed phenotypes of the ... (MG) of the human DSK2 homolog (PLIC1), 342–343 (MG) of yeast DSK2 and 401– 402 (LG) of yeast DDI1 Mutation of the UBA of human and yeast DSK2 homologs abolished binding to ubiquitin chains of ... mutation of UBA1 or UBA2 of human hHR23b reduced the binding activity of K48or K63-linked ubiquitin chains significantly, indicating that both UBAs are critical for the binding of ubiquitin chains of...

Ngày tải lên: 15/03/2014, 09:20

... has identified large families of isoforms of TAXI-type inhibitors in wheat grain [17] The amino acid sequences of TAXI-I and TAXI-II isoforms share a high degree of identity (UniProt accession ... inhibitors with a high isoelectric point and occur in two molecular forms: an intact form with a molecular mass of approximately 40 kDa; and a processed form, consisting of two polypeptides of ... active site and in the thumb region of BSX and of TAXI-type inhibitors that are crucial for xylanase-inhibitor interaction [1–4] Structural information on TAXI isoforms other than TAXI-IA is not...

Ngày tải lên: 23/03/2014, 05:22

... signal for targeted ERAD Inhibition of ER a-mannosidase I often delays the degradation of glycoproteins in the ERAD in favor of protein refolding When kifunensine, a selective inhibitor of the ... enzyme inhibitors could be useful tools for probing and assessing the folding status of a mutant protein To gain therapeutic benefits, the rescued mutant enzyme needs to be active and free of inhibitors ... Acknowledgements The authors are grateful to Dr S Garman of University of Massachusetts for providing photos of X-ray structure of a-Gal A and to Dr J Shabbeer for editorial assistance with the manuscript...

Ngày tải lên: 30/03/2014, 03:20

... Department of Sciences of Life and Reproduction, Section of Biochemistry, University of Verona, Italy 2Department of Medicine, Section of Hematology, University of Verona, Italy 3Department of Biochemistry ... possible candidate for the treatment of acute leukemias and establish a basis for studies in animal models Acknowledgements The authors thank mathematics professor Vincenza Tomasello for her criticism ... Ph-ALL) Thus, abisabolol is a pro-apoptotic agent for acute leukemia cells ex vivo, particularly for Ph-B-ALL Table a-bisabolol cytotoxicity in acute leukemia cells and in their normal counterparts...

Ngày tải lên: 18/06/2014, 19:20

... useful for 30-day prediction of MACE When used in the setting of ED patients with acute chest pain, a dichotomous cut point of less than 20% may aid identification of patients amenable for outpatient ... predictive value of 100% for MACE, our study sample was relatively small, and the wide confidence intervals for each of these values preclude widespread application of this tool for safe triage ... Figure Receiver-operating characteristics (ROC) of ACI-TIPI for prediction of MACE The black curve represents the ROC of ACI-TIPI for prediction of 30-day major adverse cardiac events (MACE),...

Ngày tải lên: 21/06/2014, 01:20

... recognition performance (using a significance test for a binomial random variable), as compared with the performance of the triphone recognisers However, the performance of the syllable-model and of the ... assigning 75% of the sentences spoken by each speaker to the training set and 12.5% to each of the test sets Second, for each of the three data sets, we calculated the probabilities of word unigrams, ... column of Table shows how much data was covered by words with different numbers of syllables As Table illustrates, the word structure of CGN was highly similar to that of TIMIT The third column of...

Ngày tải lên: 22/06/2014, 19:20